Severe Case of Tumor Lysis Syndrome Presenting Spontaneously in a Metastatic Pancreatic Adenocarcinoma Patient

Umar, Jalaluddin; Kalakonda, Aditya; Panebianco, Lauren; Kaur, Gurpreet; John, Savio

doi:10.1097/mpa.0000000000000797

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…2 Different treatment modalities have been associated with TLS in solid tumors including cytotoxic chemotherapy, hormonal therapy, monoclonal antibody therapy, targeted therapy, immune checkpoint inhibitor therapy, radiation therapy, and steroids. 2,[24][25][26][27][28][29][30][31] Although TLS has been reported in breast cancer after treatments with either gemcitabine or trastuzumab individually, our case is the first report of ATLS occurrence with the combination of both.…”

Section: Tumor Lysis Syndrome In Breast Cancermentioning

confidence: 64%

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Tumor Lysis Syndrome in Breast Cancer

Sengupta

Daw

2021

American Journal of Therapeutics

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Section: Tumor Lysis Syndrome In Breast Cancermentioning

confidence: 64%

mentioning

confidence: 99%

Tumor Lysis Syndrome in Breast Cancer

Sengupta

Daw

2021

American Journal of Therapeutics

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“…[3] In addition, two separate cases of spontaneous TLS without any treatment in patients with metastatic pancreatic adenocarcinoma have been reported. [4,5] A 2003 systemic review found only 45 reported cases of TLS in solid tumors. [6] No cases were associated with pancreatic cancer, and only 5 involved radiotherapy (3 cases neuroblastoma, 1 medulloblastoma, and 1 breast carcinoma; in two of the neuroblastoma cases, vincristine and teniposide were also delivered).…”

Section: Discussionmentioning

confidence: 99%

Tumor lysis syndrome following radiation therapy in metastatic pancreatic cancer: A case report

Song

Hong

Czito

2017

CRCP

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A 65-year-old female presented to radiation oncology for potential treatment options due to metastatic pancreatic cancer and significant abdominal pain. Imaging demonstrated a large pancreatic mass with lymphadenopathy, vascular encasement, and liver metastases. She initiated palliative radiation treatment and developed persistent nausea and vomiting, as well as significant laboratory derangements. She was subsequently admitted and diagnosed with tumor lysis syndrome, though this diagnosis is usually an oncologic emergency seen with hematologic malignancies following chemotherapy.

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Spontaneous tumor lysis syndrome in patients with solid tumors: a scoping review of the literature

Papapanou,

Athanasopoulos,

Georgiadi

et al. 2023

Med Oncol

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No systematic synthesis of all cases of spontaneous tumor lysis syndrome (STLS) in adult patients with solid tumors is available to date. Herein, we aim to recognize specific STLS characteristics and parameters related to a worse prognosis. We conducted a systematic search for randomized controlled trials, cohorts, case-control studies, and case reports. The primary endpoints were death and the need for renal replacement therapy (RRT) due to STLS. We estimated crude odds ratios (ORs) with 95% confidence intervals (95%CI) via univariate binary logistic regression. We included one cohort of 9 patients and 66 case reports of 71 patients [lung cancer 15(21.1%)]. Regarding the case reports, most patients [61(87.1%)] had metastatic disease [liver 46(75.4%)], developed acute kidney injury [59(83.1%)], needed RRT [25(37.3%)], and died due to STLS [36(55.4%)]. Metastatic disease, especially in the liver [p = 0.035; OR (95%CI): 9.88 (1.09, 89.29)] or lungs [p = 0.024; 14.00 (1.37, 142.89)], was significantly associated with STLS-related death compared to no metastasis. Cases resulting in death had a significantly higher probability of receiving rasburicase monotherapy than receiving no urate-lowering agents [p = 0.034; 5.33 (1.09, 26.61)], or the allopurinol-rasburicase combination [p = 0.023; 7.47 (1.40, 39.84)]. Patients receiving allopurinol were less likely to need RRT compared to those not receiving it or those receiving rasburicase. In conclusion, current anecdotal evidence demonstrated that metastatic disease, especially in the liver and lungs, may be associated with STLS-related death compared to no metastatic status. Careful surveillance of high-risk cases within larger studies is essential to identify markers predicting morbidity or mortality.

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Severe Case of Tumor Lysis Syndrome Presenting Spontaneously in a Metastatic Pancreatic Adenocarcinoma Patient

Cited by 6 publications

References 9 publications

Tumor Lysis Syndrome in Breast Cancer

Tumor Lysis Syndrome in Breast Cancer

Tumor lysis syndrome following radiation therapy in metastatic pancreatic cancer: A case report

Spontaneous tumor lysis syndrome in patients with solid tumors: a scoping review of the literature

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