Severe combined immunodeficiency (SCID) and rotavirus vaccination: Reports to the Vaccine Adverse Events Reporting System (VAERS)

Bakare, Nyasha; Menschik, David; Tiernan, Rosemary; Hua, Wei; Martín, David

doi:10.1016/j.vaccine.2010.07.039

Cited by 81 publications

(61 citation statements)

References 10 publications

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“…28 Rotavirus vaccine from 2 months of age is due to be introduced to our national immunization schedule in September 2013 and may result in vaccine-related illness as reported from the United States. 29 Once the presenting acute infection has resolved, patients are placed on prophylactic medication, including co-trimoxazole (to prevent Pneumocystis jirovecii infection), fluconazole or itraconazole (as antifungal prophylaxis), and Ig replacement therapy via either the intravenous or subcutaneous route. The use of antiviral prophylaxis using aciclovir is used in some centers but is not routinely used in our practice unless there is a history of herpetic infection.…”

Section: Generic Issues Related To Transplantation In Scidmentioning

confidence: 99%

How I treat severe combined immunodeficiency

Gaspar

Qasim

Davies

et al. 2013

Blood

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Severe combined immunodeficiency (SCID) arises from different genetic defects associated with lymphocyte development and function and presents with severe infections. Allogeneic hematopoietic stem cell transplantation is an extremely effective way of restoring immunity in these individuals. Numerous multicenter studies have identified the factors determining successful outcome, and survival for SCID has shown great improvement. Advances in understanding the genetic basis of disease also mean that we increasingly tailor transplant protocols to the specific SCID form. Wherever possible, we attempt to transplant SCID patients without the use of cytoreductive conditioning, but it is clear that this is only successful for specific SCID forms and, although survival is good, in specific patients there are ongoing humoral defects. We aim to use matched related and unrelated donors (including cord blood) whenever possible and have limited the use of mismatched haploidentical donors. The development of autologous hematopoietic stem cell gene therapy provides another treatment of the X-linked and adenosine deaminase–deficient forms of SCID, and we discuss how we have integrated gene therapy into our treatment strategy. These developments together with the advent of universal newborn screening for SCID should allow for a highly favorable outcome for this otherwise lethal condition.

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Section: Generic Issues Related To Transplantation In Scidmentioning

confidence: 99%

How I treat severe combined immunodeficiency

Gaspar

Qasim

Davies

et al. 2013

Blood

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“…Ağır kombine immün yetmezlik nadir görülen konjenital bir hastalık olup insidansı 1/50 000-100 000'dir. Bozulmuş T ve B hücre fonksiyonları sonucu hayatın ilk yılında tekrarlayan ağır enfeksiyonlar (ishal, pnömoni, otit, sepsis, kutanöz enfeksiyonlar) ile karekterizedir [12][13][14]. Bağışıklığı baskılanmış bu tür hastalarda akut ya da kronik ishal sık görülen bir komplikasyondur.…”

Section: Discussionunclassified

Salmonella ishali olan immün yetmezlikli bir olguda oral immünoglobulin tedavisi

Duksal¹,

Aygüneş²,

Bolat³

et al. 2013

CMJ

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Enfeksiyon ilişkili gastroenteritte en sık tanımlanan patojen virüslerden sonra salmonelladır. Salmonella'ya bağlı enfeksiyonlarda akut faz reaktanlarında artış ve ateş daha fazla görülmektedir. Salmonella enteropatojenik gram negatif basil olup lokalize enfeksiyondan sistemik enfeksiyona kadar değişen enfeksiyonlara yol açabilmektedir. En sık görülen şekli kendini sınırlayan komplike olmayan gastroenterittir. Rotavirüs ishali de Salmonella ishali gibi genel olarak kendini sınırladığı halde, bağışıklık sistemi baskılanmış hastalarda daha uzun ve ciddi seyredebilir. Daha çok rotavirüs ishallerinde yapılan çalışmalarda, verilen oral immünoglobulinin ishal süresini, semptomların şiddetini ve viral atılımı azalttığı gösterilmiştir. Salmonella ishalinde oral immünoglobilin verildiğini gösteren bir çalışmaya rastlamadık. Bu sunumda bağışıklık sistemi baskılanmış bir olguda Salmonella'ya bağlı ağır ishalin oral immünoglobulin ile tedavisi tartışılmıştır.

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“…тей, есть общая черта -нарушение Т-клеточного звена иммунитета, которое и влечет за собой классические проявления ИДС: вторичные к вакцинации БЦЖиты и рецидивирующие по-носы, пневмоцистные пневмонии, тяжелое те-чение цитомегаловирусных (ЦМВ)-инфекции, грибковых инфекций и так далее [8].…”

Section: неонатальный скрининг пидс Primary Immune Deficiency Screeniunclassified

Clinical and Epidemiological Aspects of Primary Immunodeficiency Diseases (Pid) and Early Diagnosis Options

Корсунский¹,

Gordukova²,

Munblit³

et al. 2017

Med. immunol.

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Резюме. Неонатальный скрининг первичных иммунодефицитных состояний делает возможным раннее обнаружение тяжелых и среднетяжелых поражений иммунной системы, а эффективность современных протоколов лечения этой группы заболеваний несомненна. Результаты нескольких запущенных в последние годы скрининговых программ показывают высокую чувствительность и специфичность скрининга, высокую выживаемость пациентов, что, в свою очередь, доказывает не-обходимость введения первичных иммунодефицитных состояний в программу неонатального скри-нинга России. Moscow, Russian Federation c Federal D. Rogachev Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation d Russian National Research N.I. Pirogov Medical University, Moscow, Russian Federation Abstract. Neonatal screening for primary immunodeficiencies (PID) provides a unique opportunity for early detection of moderate to severe immune disorders. Thus, the patients could be provided with best available Адрес для переписки: Корсунский Илья Анатольевич ГБУЗ «Детская городская больница № 9 имени Г.Н. Ключевые слова: ПИД, ТКИН, неонатальный скрининг, TREC, KREC CLINICAL AND EPIDEMIOLOGICAL ASPECTS OF PRIMARY IMMUNODEFICIENCY DISEASES (PID) AND EARLY DIAGNOSIS OPTIONS

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Severe combined immunodeficiency (SCID) and rotavirus vaccination: Reports to the Vaccine Adverse Events Reporting System (VAERS)

Cited by 81 publications

References 10 publications

How I treat severe combined immunodeficiency

How I treat severe combined immunodeficiency

Salmonella ishali olan immün yetmezlikli bir olguda oral immünoglobulin tedavisi

Clinical and Epidemiological Aspects of Primary Immunodeficiency Diseases (Pid) and Early Diagnosis Options

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