Severe COVID-19 cases with a history of active or latent tuberculosis

Liu, Chang; Yu, Yejiong; Fleming, J; Wang, T; Shen, Shuiwen; Wang, Y; Lin, Fan; Ma, Jing; Gu, Ye; Chen, Y

doi:10.5588/ijtld.20.0163

Cited by 34 publications

(43 citation statements)

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“…Each article that met selection criteria was fundamentally assessed for Author/Country, Population/Study design, Exposures, Comparators, Treatments, TB occurrence and SARS/MERS/COVID-19 severity, recovery and mortality rate. [41,44,45,48], one case control study [38] and four case series [28,29,34,49] were conducted in China, two case series [30,39] were done in Singapore, one case series [32] and one case control study [37] were undertaken in Saudi Arabia, a case series [40] was conducted in Italy, one cohort study was done in South Africa [42] and another in the Philippines [43], one case study was conducted in the United State of America [35], other three case studies were found in Turkey [36], Hong Kong [31] and India [33] respectively. Lastly, a retrospective cohort was undertaken in eight countries (Italy, Belgium, Brazil, France, Russia, Singapore, Spain, and Switzerland) [47].…”

Section: Search Resultsmentioning

confidence: 99%

Implications of COVID-19 in high burden HIV/TB countries: A systematic review of evidence

Tamuzi¹,

Birhanu²,

Shumba³

et al. 2020

Preprint

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Background The triple burden of COVID-19, tuberculosis and human immunodeficiency virus is one of the major global health challenges of the 21st century and in the future. In high burden HIV/TB countries, the spread of COVID-19 among people living with HIV is a well-founded concern. A thorough understanding of HIV/TB and COVID-19 pandemics is important as the three diseases interact. This may clarify HIV/TB/COVID-19 as a newly related field and play an important role in the present and future management of the co-infections. However, several gaps are remaining in the knowledge of the burden of COVID-19 on patients with TB and HIV, the diagnosis, and management of these patients. The study was conducted to review different studies on SARS-CoV, MERS-CoV or COVID-19 associated with HIV/TB co-infection or only TB and to understand the interactions between HIV, TB and COVID-19 and its implications on the burden of the COVID-19 among HIV/TB co-infected or TB patients, screening algorithm and clinical management. Methods We conducted electronic search of potential eligible studies published in English in the Cochrane Controlled Register of Trials, PubMed, Medrxiv, Google scholar and Clinical Trials Registry databases. We included case studies, case series and observational studies published between January, 2002 and March, 2020 in which SARS-CoV, MERS-CoV and COVID-19 co-infected to HIV/TB or TB were managed in adult patients. We screened titles, abstracts and full articles for eligibility. As we anticipated heterogeneity in the literature, results were reported narratively. Results After removing 69 duplicates, 24 out of 246 articles were assessed for eligibility, of which 9 studies were included for qualitative analysis. Among them, we included two case reports, four case series, one case-control and two retrospective observational studies. The studies have shown that TB may occur during or after SARS-CoV. In terms of severity, the proportion of severe/critical SARS, MERS and COVID cases with TB co-infection was higher than in patients with mild/moderate stages (P = 0.0008). Conclusion SARS/MERS-CoV/COVID-19 associated to HIV/TB or TB subjects had a higher risk of developing severe/critical than mild/moderate SARS/MERS-CoV/COVID-19. Diagnostic algorithms and clinical management were suggested for efficiently improving COVID-19/HIV/TB co-infections outcomes.

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Section: Search Resultsmentioning

confidence: 99%

Implications of COVID-19 in high burden HIV/TB countries: A systematic review of evidence

Tamuzi¹,

Birhanu²,

Shumba³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Since COVID-19 being declared as a global pandemic [6], co-infection with another pandemic as TB [1] was inevitable. Co-infection case reports have been on the rise [7][8][9][10][11], reaching to a cohort of 69 cases in the literature [5], describing respiratory symptoms almost exclusively without neurological involvement aside from one case that reported TB meningitis [12]. Our patient is an interesting case to report as he had a very rare form of neurological manifestation associated with his miliary TB that is axonal sensorimotor polyneuropathy causing bilateral foot-drop in the background of COVID-19 infection (whether COVID-19 was a confounding factor or synergistic one is unclear due to limited knowledge of this new disease) and malnutrition.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Foot-Drop Secondary to Axonal Neuropathy in a Tuberculosis Patient With Co-Infection of COVID-19: A Case Report

Alkhateeb¹,

Aziz²,

Eltahir³

et al. 2020

Cureus

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Tuberculosis (TB) is a global pandemic and is one of the top 10 causes of death worldwide as well as the leading cause of death from a single infectious agent. It can cause a wide array of complications including peripheral neuropathy. In addition to TB pandemic the recent pandemic of coronavirus disease 2019 (COVID-19) has led to an increased interest in the co-infection of TB patients and COVID-19 and whether TB increases risk for COVID-19 and its role in causing severity of disease and vice-versa. This case report discusses about a young cachectic man who was found to have bilateral foot-drop under the setting of TB with co-infection of COVID-19 later confirmed to be axonal neuropathy on nerve conduction study. The report highlights the importance of differential diagnosis of TB in COVID-19 patients as well as the consideration of TB in a patient with peripheral neuropathy after nutritional causes have been ruled out.

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“…This relationship could not be underestimated as few studies have recently reported coinfection of SARS-CoV-2 with TB as summarized in Table 1. [12][13][14][15][16][17][18][19] An observational study recently reported that persons with latent TB have increased susceptibility for SARS-CoV-2 infection associated with rapid progression and severe involvement. [16] TB infection was more common among patients with SARS-CoV-2 infection than in those with bacterial or other viral infections.…”

Section: Discussionmentioning

confidence: 99%

Severe Acute Respiratory Syndrome Coronavirus-2 and Pulmonary Tuberculosis Coinfection: Double Trouble

Singh¹,

Gupta²,

Das

2020

Preprint

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Background: The ongoing pandemic of novel coronavirus disease 2019 (COVID-19) has received worldwide attention by becoming a major global health threat. We encountered one case with COVID-19 and tuberculosis (TB) coinfection which has not been frequently reported. Case presentation: A 76 year old female presented with acute respiratory symptoms superimposed on chronic symptoms, suggestive to have pneumonia. Oropharyngeal throat swab sample for COVID-19 was positive as detected by real-time reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assay. GeneXpert Ultra detected Mycobacterium tuberculosis complex with Rifampicin resistance indeterminate. Patient was treated with appropriate management. Conclusion: Clinicians should suspect coinfection with TB during ongoing pandemic of COVID-19 as therapeutic strategies need to be determined timely to improve outcome and prevent transmission in community.

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Severe COVID-19 cases with a history of active or latent tuberculosis

Cited by 34 publications

References 0 publications

Implications of COVID-19 in high burden HIV/TB countries: A systematic review of evidence

Implications of COVID-19 in high burden HIV/TB countries: A systematic review of evidence

Bilateral Foot-Drop Secondary to Axonal Neuropathy in a Tuberculosis Patient With Co-Infection of COVID-19: A Case Report

Severe Acute Respiratory Syndrome Coronavirus-2 and Pulmonary Tuberculosis Coinfection: Double Trouble

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