Severe Dengue: Developing a Universally Applicable Simple Prediction Model

Singhi, Sunit

doi:10.1007/s12098-018-2668-2

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…Dengue Infection is still a public health problem in the world. Reported by WHO, about 50 million dengue infections worldwide with 75 percent being in Asia (Hsan et al, 2019;Singhi, 2018). In 2015 there were reported at least 451,000 cases of dengue in Southeast Asia (Maula et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

RESISTANCE STATUS AND MECHANISM OF Aedes aegypti AGAINST THREE CLASSES OF INSECTICIDES IN SALATIGA CITY, INDONESIA

Hidajat¹,

Setyaningsih²,

Ristiyanto³

et al. 2022

Proceeding of the International Conference on Public Health

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Insecticide resistance is a major problem in dengue vector control in Indonesia. Salatiga City, one of Central Java's dengue-endemic areas, has been using insecticide for vector control for decades. To select the insecticide used, it is necessary to understand the status and mechanism of resistance to various insecticides. This study aimed to determine the status and mechanism of Aedes aegypti resistance in Salatiga City. This study used a descriptive method. Larvae were collected from 8 endemic villages in Salatiga City. The larvae were then reared to produce adult mosquitoes. A resistance test was conducted using the WHO-Impregnated paper method on F1 mosquitoes. The insecticides used for the test were malathion 5%, phenytotrione 1% (Organophosphate); Bendiocarb 0.1%, Propoxur 0.1% (Carbamate); Lambda Cyhalothrin 0.03%, Deltamethrin 0.05%, Permethrin 0.25%, and Cypermethrin 0.05.% (Pyretrhoid). To determine the resistance mechanism of the target site mutation, sequencing of the Domain II VGSC and ACE1 genes was carried out. The test results showed that Ae. aegypti from 8 locations were resistant to all insecticides. The highest mortality after 24 hours observation was on organophosphate group. Molecular tests showed that Single Nucleotide Polymorphism had occurred in the S989P and V1016G alleles of the VGSC gene, indicating molecular resistance to Pyretrhoid insecticides. The ACE1 gene sequences showed no mutations in the G119S allele, indicating the possibility of metabolic resistance to organophosphates and carbamates. In case of a dengue outbreak, it is recommended to use organophosphate because it has the highest percentage of mosquito mortality, and only metabolic resistance occurs without target site mutations.

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Section: Introductionmentioning

confidence: 99%

RESISTANCE STATUS AND MECHANISM OF Aedes aegypti AGAINST THREE CLASSES OF INSECTICIDES IN SALATIGA CITY, INDONESIA

Hidajat¹,

Setyaningsih²,

Ristiyanto³

et al. 2022

Proceeding of the International Conference on Public Health

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“…6 Severe dengue fever which is characterized by severe thrombocytopenia accompanied with significant bleeding, plasma leakage which in turn can cause pedal edema, ascites, pleural effusion, respiratory distress and Multi-Organ Dysfunction Syndrome (MODS). 7 Prior studies have identified various biomarkers for immune and endothelial cell activation as a predictor of the severity of dengue. Ferritin is an acute-phase reactant which is produced by reticulo-endothelial cells as a response to infection and inflammation.…”

mentioning

confidence: 99%

Comparative study of serum ferritin levels and hepatic transaminases between uncomplicated paediatric dengue inpatients and other febrile illnesses in Kanchipuram, India

Reddy

Kadambi

Aashiq

et al. 2020

Int J Contemp Pediatr

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Background: Fever is the most common complaint with bringing children for hospital consultation. Dengue is a cause of public health concern with case fatality rate of 1%. Ferritin is an acute-phase reactant which is produced in response to infection and inflammation. Liver enzymes are also considered as markers of febrile illness. Aim of this study was to assess serum ferritin levels, aspartate-aminotransferase (AST) and alanine-aminotransferase (ALT) levels in pediatric inpatients with febrile illness, to correlate it with patient’s Dengue profile and to analyse these parameters with sub-group analysis of dengue and OFI.Methods: Among 120 children admitted for fever of more than 3 days duration were included in the study. 58 were Dengue-NS1 positive and the remaining 62 were considered to be OFI. Serum ferritin levels, AST and ALT were the investigative parameters measured at the time of admission for the study and treated as per WHO Dengue Guidelines. Data was coded and entered in Microsoft Excel 2013. Data was analysed using SPSS v16. p value of <0.05 was considered statistically significant.Results: Ferritin levels were higher in Dengue-IgM positive subgroup than in OFI subgroup (U= 173, Z score -6.09, p<0.00001). AST levels are higher in Dengue-NS1 positive subgroup than in OFI subgroup (U= 103, Z score -8.08, p<0.00001). AST levels were also higher in Dengue-IgM positive subgroup than in OFI subgroup (U= 377.5, Z score -4.86, p<0.00001). ALT levels are higher in Dengue-NS1 positive subgroup than in OFI subgroup (U=76, Z score -8.95, p<0.00001) as well as in Dengue-IgM positive subgroup than in OFI subgroup (U= 417, Z score -4.4, p<0.00001).Conclusions: Hyperferritinemia and elevation of hepatic-transaminases is seen in dengue. Although elevated in other febrile illnesses, it is elevated more so in dengue. This can be a predictor of severity of dengue fever, but needs to be confirmed in larger studies.

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Severe Dengue: Developing a Universally Applicable Simple Prediction Model

Cited by 2 publications

References 10 publications

RESISTANCE STATUS AND MECHANISM OF Aedes aegypti AGAINST THREE CLASSES OF INSECTICIDES IN SALATIGA CITY, INDONESIA

RESISTANCE STATUS AND MECHANISM OF Aedes aegypti AGAINST THREE CLASSES OF INSECTICIDES IN SALATIGA CITY, INDONESIA

Comparative study of serum ferritin levels and hepatic transaminases between uncomplicated paediatric dengue inpatients and other febrile illnesses in Kanchipuram, India

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