Severe depletion of peripheral blood dendritic cell subsets in obstructive sleep apnea patients: A new link with cancer?

Galati, Domenico; Zanotta, Serena; Canora, Angelo; Polistina, Giorgio Emanuele; Nicoletta, Carmine; Ghinassi, Giacomo; Ciasullo, Emanuele; Bocchino, Marialuisa

doi:10.1016/j.cyto.2019.154831

Cited by 17 publications

(22 citation statements)

References 59 publications

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“…After evaluating the full texts, 50 articles were excluded as mentioned in Study Selection . At the end, 63 studies were included in the present meta-analysis ( 12 , 26 – 87 ).…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Table 1 , of the 63 studies retained for analysis, 14 were conducted in China ( 27 , 39 , 46 , 50 , 51 , 54 , 55 , 58 , 65 , 73 , 77 , 81 , 82 , 86 ), eight in the USA ( 26 , 28 , 34 , 38 , 56 , 76 , 78 , 83 ), six in Greece ( 37 , 43 , 47 , 49 , 58 , 64 ), six in Japan ( 29 – 31 , 41 , 42 , 44 ), six in Turkey ( 12 , 57 , 62 , 67 , 68 , 70 ), three in Italy ( 59 , 63 , 87 ), 3 in Brazil ( 45 , 53 , 72 ), three in Spain ( 36 , 60 , 71 ), two in Sweden ( 66 , 84 ), two in India ( 79 , 85 ), one in Ireland ( 32 ), one in Germany ( 35 ), one in Thailand ( 40 ), one in Finland ( 48 ), one in Canada ( 52 ), one in the UK ( 74 ), one in Croatia ( 80 ), one in Australia ( 33 ), one in Taiwan ( 69 ), and one in Belgium ( 75 ). With regard to ethnicity, 28 studies were performed with Caucasians ( 12 ,…”

Section: Resultsmentioning

confidence: 99%

“…With regard to ethnicity, 28 studies were performed with Caucasians ( 12 , 32 , 35 – 37 , 43 , 47 – 49 , 57 , 59 – 64 , 66 – 68 , 70 , 71 , 74 , 75 , 79 , 80 , 84 , 85 , 87 ), 22 with Asians ( 27 , 29 – 31 , 39 – 42 , 44 , 46 , 50 , 51 , 54 , 55 , 58 , 65 , 69 , 73 , 77 , 81 , 82 , 86 ), and 13 with mixed ethnicities ( 26 , 28 , 33 , 34 , 38 , 45 , 52 , 53 , 56 , 72 , 76 , 78 , 83 ). Of the 63 studies, 40 reported IL-6 levels in serum ( 12 , 28 , 30 – 34 , 37 , 39 , 40 , 44 , 46 , 47 , 49 – 57 , 62 , 63 , 65 – 68 , 70 ...…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

et al. 2020

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Obstructive sleep apnea syndrome (OSAS) is considered a low-grade chronic inflammatory disease. Interleukin-6 (IL-6) is one of the most significant inflammatory markers and an excellent proxy for the inflammatory/immune system. The present meta-analysis and meta-regression aimed at comparing plasma and serum levels of IL-6 between individuals (children and adults) with OSAS and healthy controls. Four databases, PubMed/Medline, Scopus, Cochrane Library, and Web of Science, were comprehensively searched to retrieve articles published up to December, 2019, with no further restrictions. RevMan 5.3 software was used to calculate the crude mean difference (MD) and 95% confidence interval (CI). The results of funnel plots and meta-regression were analyzed by the CMA 2.0 software. Sixty-three studies (57 with adults; six with children) were included in the present meta-analysis. For adults, 37 studies reported significantly higher serum IL-6 levels and 20 reported significantly higher plasma IL-6 levels for those with OSAS than for healthy controls [pooled MD of 2.89 pg/ml ( P < 0.00001) and pooled MD of 2.89 pg/ml ( P < 0.00001), respectively]. The pooled analysis of serum and plasma IL-6 levels in children with OSAS compared with controls revealed that only the MD of plasma IL-6 levels was significant (MD = 0.84 pg/ml, P = 0.004). Results of the meta-regression showed that greater age was associated with higher serum IL-6 levels. Egger's test revealed a publication bias across the studies for serum and plasma IL-6 levels ( P = 0.00044 and P = 0.01445, respectively). In summary, the meta-analysis and meta-regression confirmed that, compared to healthy controls, individuals with OSAS (children and adults) had higher serum/plasma IL-6 levels.

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“…After evaluating the full texts, 50 articles were excluded as mentioned in Study Selection . At the end, 63 studies were included in the present meta-analysis ( 12 , 26 – 87 ).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

et al. 2020

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“…Among adult participants, eighteen studies were performed with Caucasians [ Table 1 presents the characteristics of the 55 studies included in the meta-analysis. Forty-six studies [16,[28][29][30][31][32][33][34][35][36][38][39][40][41][43][44][45][46][47][48][49][50][51][52]54,[56][57][58][59][60][61][62][63][64][65][67][68][69][70][71][72]75,76,[78][79][80] reported serum or plasma TNF-α concentrations in adults, and nine studies [14,37,...…”

Section: Search Strategiesmentioning

confidence: 99%

“…Among adult participants, eighteen studies were performed with Caucasians [31,34,36,[39][40][41][46][47][48][49]59,61,63,65,68,69,75,80], nineteen sampled Asians [16,29,32,33,35,43,45,52,54,58,60,62,64,67,71,72,76,78,79], and nine samples mixed [28,30,38,44,50,51,56,57,70] ethnicities. For studies with adult samples, 29 out of 46 studies reported serum TNF-α concentrations [16,[31][32][33]…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

Imani

Sadeghi

Khazaie

et al. 2020

Life

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Background: Obstructive sleep apnea syndrome (OSAS) is associated with a variety of inflammatory factors. Specifically, proinflammatory cytokines appear to be associated with the pathogenesis of OSAS. Methods: For the present meta-analysis and meta-regression on serum and plasma tumor necrosis factor alpha (TNF-α) levels in individuals with and without OSAS, we performed a systematic search without any restrictions of the PubMed/Medline, Scopus, Cochrane Library, and Web of Science databases to find relevant articles published up to 1 February 2020. Results: Fifty-five (adults: 29 studies on serum and 17 studies on plasma; children: 4 studies on serum and 5 studies on plasma) were included and analyzed. Always compared to age-matched healthy controls, the pooled MDs were as follows: adults, serum: 10.22 pg/mL (95% CI = 8.86, 11.58; p < 0.00001); adults, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; p < 0.00001); children, serum: 0.21 pg/mL (95% CI = 0.05, 0.37; p = 0.01); children, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; p < 0.00001). Conclusions: Compared to healthy and age-matched controls, adult individuals with OSAS had significantly higher serum/plasma TNF-α levels. For children with OSAS, significantly higher levels were observed for TNF-α in serum but not in plasma.

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COVID‐19: Prevention, Detection, and Treatment by Using Carbon Nanotubes‐Based Materials

et al. 2023

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The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was responsible for the outbreak of coronavirus disease . The respiratory illness has rapidly spread worldwide and has claimed millions of lives. Although most countries have entered the endemic phase, health authorities warned that future variants could be more virulent than the existing ones. Since clinical trials of antiviral drugs for COVID-19 may last even a year before approval, developing alternative approaches to combat the virus becomes mandatory. Previ-ously, carbon nanotubes (CNTs) have exhibited an impressive track record in controlling numerous viral diseases, including COVID-19. In this article, we review recent applications of CNTs for the prevention, detection, and treatment of COVID-19. We highlight the strategies and prospective developments of CNTs in producing personal protection equipment (PPE), vaccines, immune-triggering, development of biosensors and therapeutic strategies. Finally, the challenges, limitations, and future outlook of CNTs in combating COVID-19 are also discussed.

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Severe depletion of peripheral blood dendritic cell subsets in obstructive sleep apnea patients: A new link with cancer?

Cited by 17 publications

References 59 publications

Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

COVID‐19: Prevention, Detection, and Treatment by Using Carbon Nanotubes‐Based Materials

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