Severe depression of the respiratory center in myxedema

Massumi, Rashid A.; Winnacker, J.L.

doi:10.1016/0002-9343(64)90117-2

Cited by 85 publications

(23 citation statements)

References 20 publications

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“…[26][27][28][29][30][31] Hypothyroidism has been associated with sleep disordered breathing. 32 Nine out of eleven consecutive patients with hypothyroidism were reported to have OSA. 33 However, the prevalence of hypothyroidism was only 3% in 65 consecutive patients diagnosed to have OSA.…”

Section: Pharmacological Therapy:-mentioning

confidence: 99%

Obstructive Sleep Apnea: Part Ii. Treatment Modalities.

Babu¹,

CM²,

PC³

et al. 2017

IJAR

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Section: Pharmacological Therapy:-mentioning

confidence: 99%

Obstructive Sleep Apnea: Part Ii. Treatment Modalities.

Babu¹,

CM²,

PC³

et al. 2017

IJAR

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“…(Simsek et al, 2004) In humans, approximately, one third of the hypothyroid patients have a blunted 53 ventilatory response to hypoxia/hypercapnia. (Zwillich et al, 1975, Duranti et al, 1993, Massumi RA, 1964 Predictors of blunted ventilatory response in hypothyroidism have been identified as female gender and very high levels of thyrotropin (>90 mIU/l). (Ladenson et al, 1988) It is the severe form of hypothyroidism that is associated with diminished ventilatory control.…”

Section: Ventilatory Drivementioning

confidence: 99%

“…(Massumi RA, 1964) Following that, studies have investigated further the prevalence of OSA in hypothyroidism population and vice versa (Table 1). Overall, the prevalence of clinical hypothyroidism in patients diagnosed with OSA or referred to sleep centers with a clinical suspicion of OSA is not higher than the prevalence in the general population.…”

Section: Prevalence Studies Of Hypothyroidism In Osamentioning

confidence: 99%

Hypothyroidism and Obstructive Sleep Apnea

Al-Jawder¹,

BaHammam²

2012

Hypothyroidism - Influences and Treatments

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“…factor but was not the sole cause as one patient had complete In 1964, Massumi and Winnacker (1964) described apneic resolution of his events with only modest weight loss. Grunstein breathing in a patient with myxedema.…”

Section: Sleep Apnoea In Hypothyroidism Pathophysiologymentioning

confidence: 99%

Sleep apnoea in endocrine diseases

Rosenow

McCarthy

Caruso

1998

Journal of Sleep Research

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The pertinent literature on the prevalence, clinical manifestations and pathogenic mechanisms of sleep apnoea (SA) in endocrine diseases, namely acromegaly, Cushing syndrome, hypothyroidism and diabetes mellitus was reviewed. An increased prevalence is well documented in patients with active and treated acromegaly. While most authors report peripheral obstruction, due to hypertrophy of tongue and pharyngeal tissues, to be the cause of SA in acromegaly, some findings argue for a role of hormone‐induced changes of central respiratory control. SA is also more common in hypothyroidism, especially when myxedema is present. The associated edema and myopathy appear to be of pathogenic importance. Thyroxin substitution is frequently effective for the treatment of SA but nCPAP can be necessary initially and in some patients even after remission of clinical signs of hypothyroidism. In Cushing disease and syndrome, parapharyngeal fat accumulation can cause SA, but no epidemiological information is available. In non insulin dependent diabetes (NIDDM), obesity is the common risk factor for both, nocturnal hypoxia and insulin resistance. In IDDM, the development of autonomic neuropathy may predispose to SA. Where treatment of the underlying endocrine disease is unable cure the associated SA, nCPAP is usually the treatment of first choice. More prospective studies are clearly needed to establish prevalences and resolve the controversies regarding pathogenesis.

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Severe depression of the respiratory center in myxedema

Cited by 85 publications

References 20 publications

Obstructive Sleep Apnea: Part Ii. Treatment Modalities.

Obstructive Sleep Apnea: Part Ii. Treatment Modalities.

Hypothyroidism and Obstructive Sleep Apnea

Sleep apnoea in endocrine diseases

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