Severe Depressive Mood Changes Following Slow-release Intramuscular Fluphenazine Injection

Depressão na esquizofrenia: prevalência e relação com a qualidade de vida

“…Estudos relatam uma associação entre medicação de depósito e depressão, sugerindo que estas drogas podem induzir à "depressão farmacogênica", principalmente quando usada em dosagem maior do que a necessária 47 . Em nosso estudo, 95% dos pacientes relataram o uso de medicação neuroléptica, dentre estes, 24% usavam medicação de depósito.…”

Depression in Schizophrenia: Perspective in the Era of “Atypical” Antipsychotic Agents

“…Therefore, dopamine blockade by a neuroleptic drug could theoretically lead to anhedonia and, perhaps, depression. Indeed, a state of dysphoria is commonly described by neuroleptic-treated patients (34), a number of older anecdotal reports have suggested a link between neuroleptic use and depression (35)(36)(37)(38)(39), and one study found more anhedonia and depression in maintenance-phase schizophrenic patients who were taking neuroleptics than in others who were not (33). Another study found a positive relationship between haloperidol plasma levels and depressive symptoms in the context of a positive association between extrapyramidal symptoms and depressive symptoms (40), and impairments of quality of life related to neuroleptic-induced dysphoria have been reported (41).…”

The symptom of depression in schizophrenia and its management

“…There have been three principal proposed roles (Table 2). Thirty years ago, it was proposed that antipsychotics acted directly causing 'pharmacogenic depression' (De Alarcon & Carney, 1969). There is a possible theoretical explanation for this as antipsychotics act primarily on dopaminergic pathways and dopamine plays a major role in reward and pleasure mechanisms.…”