2014
DOI: 10.1167/iovs.14-14603
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Severe, Early Axonal Degeneration Following Experimental Anterior Ischemic Optic Neuropathy

Abstract: Following a photochemical thrombosis model of AION, RGC axons displayed severe degenerative changes within 1 week, suggesting that after ischemia, RGC axons may degenerate in a temporally and spatially distinct fashion from that of the soma. Our findings also further established annexin-V as a useful marker of retinal degeneration because it strongly labeled dying RGC axons.

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Cited by 16 publications
(6 citation statements)
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“…Several studies have examined the dendritic morphology of the Thy1-YFP expressing RGCs, both ex vivo Kalesnykas et al, 2012;Feng et al, 2013) and in vivo (Walsh and Quigley, 2008;Leung et al, 2011;Li et al, 2011;Lee et al, 2014b), demonstrating that dendritic shrinkage is observed in GON. It has been suggested that after injury, but before cell death, the dendrites of RGCs retract and branching is reduced (i.e.…”
Section: Thy1-yfp-hmentioning
confidence: 99%
“…Several studies have examined the dendritic morphology of the Thy1-YFP expressing RGCs, both ex vivo Kalesnykas et al, 2012;Feng et al, 2013) and in vivo (Walsh and Quigley, 2008;Leung et al, 2011;Li et al, 2011;Lee et al, 2014b), demonstrating that dendritic shrinkage is observed in GON. It has been suggested that after injury, but before cell death, the dendrites of RGCs retract and branching is reduced (i.e.…”
Section: Thy1-yfp-hmentioning
confidence: 99%
“…Evidence from rAION models suggests that reducing inflammation and ON edema in the acute phase may be effective in protecting neurons from degeneration (Goldenberg-Cohen et al, 2005; Slater et al, 2008; Zhang et al, 2009, 2010; Touitou et al, 2013; Chang et al, 2014; Lee et al, 2014). Therefore, it is important to identify the optimal timing of G-CSF treatment in rAION and the related mechanisms.…”
Section: Introductionmentioning
confidence: 99%
“…In experimental AION models and histological studies, Lee et al 24 reported that RGC axons showed severe degenerative changes within 1 week after the ischaemic event. Slater et al 25 reported that apoptosis of the RGC occurs maximally in the 2 to 3 weeks after an infarct.…”
Section: Discussionmentioning
confidence: 99%