2017
DOI: 10.1152/japplphysiol.00454.2017
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Severe energy deficit upregulates leptin receptors, leptin signaling, and PTP1B in human skeletal muscle

Abstract: In obesity, leptin receptors (OBR) and leptin signaling in skeletal muscle are downregulated. To determine whether OBR and leptin signaling are upregulated with a severe energy deficit, 15 overweight men were assessed before the intervention (PRE), after 4 days of caloric restriction (3.2 kcal·kg body wt·day) in combination with prolonged exercise (CRE; 8 h walking + 45 min single-arm cranking/day) to induce an energy deficit of ~5,500 kcal/day, and following 3 days of control diet (isoenergetic) and reduced e… Show more

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Cited by 16 publications
(24 citation statements)
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“…The resting metabolic rate was not significantly altered by the intervention. The vastus lateralis exhibited a higher proportion of MHC I than the deltoids (52.2 ± 14.4 and 41.5 ± 5.5%, respectively, P = .005) …”
Section: Resultsmentioning
confidence: 85%
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“…The resting metabolic rate was not significantly altered by the intervention. The vastus lateralis exhibited a higher proportion of MHC I than the deltoids (52.2 ± 14.4 and 41.5 ± 5.5%, respectively, P = .005) …”
Section: Resultsmentioning
confidence: 85%
“…The general effects of the interventions are reported with more detail in previous publications . Briefly, in the overweight walking group, the combination of caloric restriction with prolonged exercise elicited an energy deficit of 5500 kcal/day .…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…Previous studies that elucidated cellular signaling pathways affected by physiologic bioenergetic challenges focused on either intermittent exercise or food deprivation, but they did not include subjects maintained on food deprivation plus exercise protocols. Recent findings suggest that exercise can prevent loss of muscle mass in humans on low-calorie diets by a mechanism that in part involves up-regulation of leptin receptors and increased fatty acid oxidation in muscle cells (19,20). Further studies in which the combined effects of dietary energy restriction and exercise on the molecular, cellular, and functional responses of organ systems may lead to novel insight into the mechanisms by which organisms adapt to intermittent metabolic switching from glucose in the fed state to fatty acids and ketones in the fooddeprived state.…”
mentioning
confidence: 99%