Severe eosinophilic infiltration in colonic biopsies predicts patients with ulcerative colitis not responding to medical therapy

Abstract

Assessing the severity of eosinophilic infiltration in the lamina propria of colonic biopsies in patients with ulcerative colitis could be a valuable predictive tool of response to medical therapy.

Prognostic value of histological activity in patients with ulcerative colitis in deep remission: A prospective multicenter study

“…Histological activity has demonstrated to be a predictor of clinical relapse but also of other outcomes such as the need for steroids, hospitalization and response to treatment. 25,26 In our cohort, the presence of neutrophils either in the lamina propria (GS ¼ 2B.1) or in the epithelium (GS ¼ 3.1) was the only independent risk factor to predict clinical relapse in UC patients in clinical and endoscopic remission. Of note, histological activity was a stronger predictor of clinical relapse than endoscopic activity defined by a Mayo endoscopic sub-score of 1 in this cohort of UC patients in clinical remission with a Mayo endoscopic sub-score of 0 or 1.…”

The emerging role of histologic disease activity assessment in ulcerative colitis

“…33 Eosinophils were evaluated in a study of 32 patients with active UC. 34 A severe increase in mucosal eosinophils as measured on a Likert scale (0-3) was predictive of poor therapeutic response. In addition, both peripheral and tissue eosinophilia were associated with corticosteroid use in a pediatric study of 96 patients with UC.…”

Quantitative Analysis of Distribution of the Gastrointestinal Tract Eosinophils in Childhood Functional Abdominal Pain Disorders

“…28 Furthermore, eosinophil counts or eosinophil cationic protein levels positively correlated with disease activity and negatively correlated with treatment response in IBD patients. 17,29,30 Therefore, eosinophils are known to play a role in the pathogenesis of IBD, even though their exact relationship with IBD remains unclear. 11,28,31,32 We hypothesized that micro-inflammation may be the primary pathogenesis that causes GI symptoms in FAPDs.…”