Severe facial swelling in a pregnant woman after using hair dye

Genderen, Michel E van; Carels, Ginette; Lonnee, Edward R.; Dees, A

doi:10.1136/bcr-2013-202562

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…There have been several reports of severe cases of ACD presenting to ED and requiring hospitalization. These causes include topical PPD from both hair dye and a temporary tattoo, topical bufexamac and ketoprofen 5,15–17,24,25 . In a Danish study of children with ACD to PPD, it was reported that 1 child had been admitted to intensive care and 5 to hospital 25 .…”

Section: Discussionmentioning

confidence: 99%

“…These causes include topical PPD from both hair dye and a temporary tattoo, topical bufexamac and ketoprofen. 5,[15][16][17]24,25 In a Danish study of children with ACD to PPD, it was reported that 1 child had been admitted to intensive care and 5 to hospital. 25 Consumer reporting of 55 severe hair dye allergic reactions also identified 5 hospital admissions, 7 persons who had never seen a doctor, only 14 having seen a dermatologist and only 8/55 had had patch testing intially.…”

Section: Discussionmentioning

confidence: 99%

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Presentations to emergency departments in Melbourne, Australia diagnosed as allergic contact dermatitis

et al. 2022

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Background: This study investigated cases diagnosed as allergic contact dermatitis (ACD) in emergency departments (EDs) and management. Methods: A multisite retrospective study of patients attending EDs in metropolitan Melbourne between July 2017 and June 2018 was performed. Using International Statistical Classification of Disease-10 (ICD-10) codes, the Victorian Agency for Health Information generated a list of cases of contact dermatitis (CD). Demographic and clinical data were analysed.Results: Two hundred twenty-eighty patients from 14 different sites were diagnosed with ACD. Hair dyes caused the most cases, and one such case was admitted to hospital.It was apparent from the specified causes that cases of irritant CD were misdiagnosed as ACD.There were significant differences in management with dermatology input, with dermatologists more often advising oral corticosteroids (33.3% vs. 14.5%, P = 0.004) topical corticosteroids (92.9% vs. 38.7%, P < 0.01), emollients (38.1% vs. 20.4%, P = 0.01) and less often advising antihistamines (16.7% vs. 44.6%, P < 0.001). With dermatology input, potent or very potent steroids were more likely to be prescribed (69.3% vs. 11.1%, P < 0.001); without, a mild potency steroid was more likely to be prescribed (63.9% vs. 4%, P = 0.01). Conclusion:Improved understanding, diagnosis and management of CD are needed in EDs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Presentations to emergency departments in Melbourne, Australia diagnosed as allergic contact dermatitis

et al. 2022

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“…[25][26][27]55 Balsam of Peru, a fragrance common in shampoo, and paraphenylenediamine, a common ingredient in hair dyes and henna tattoos, are 2 common culprits known to cause ACD in the face and can be mistakenly diagnosed as a contact uritcaria. 24,25,[28][29][30][31]56 Although urticaria is usually treated via systemic agents, 57 topical over-the-counter preparation and prescription corticosteroids are also commonly used, which could precipitate ACD.…”

Section: Discussionmentioning

confidence: 99%

Allergic Contact Dermatitis and Concomitant Dermatologic Diseases: A Retrospective Study

2020

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Background: Allergic contact dermatitis (ACD) can exist in the setting of other dermatologic conditions. It is known that the treatment of these conditions can cause ACD, increasing both diagnostic and treatment difficulty.Objective: The aim of this study was to determine the frequency of common dermatologic conditions in the setting of ACD and in specific patient populations.Methods: A retrospective database study was completed using Truven Health to collect information on patch-tested ACD patients. Demographics and diagnostic information were retrieved. Of those with ACD, the presence of 15 dermatologic diagnoses was investigated. Subanalyses were conducted for each condition, including International Classification of Diseases, 10th Revision code specificity, demographics, and diagnostic information.Results: A total of 6380 patients (76.83% female) were given a diagnosis of ACD via patch testing. Of those with concomitant disease, those most common include atopic dermatitis (23.98%), urticaria (16.69%), and acne (11.51%). Eight of the concomitant conditions were found to have statistical significance in comparing the average age of ACD diagnosis with the selected diagnoses (a = 0.05).Conclusions: Common dermatologic diseases can exist concomitantly with ACD, many of which can be treated by compounds that precipitate or worsen preexisting ACD. The average age of the diagnosis varies from concomitant diagnoses, which can contribute to difficulty in ACD diagnosis and treatment.

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“… 58 − 60 Nevertheless, skin exposure to hair dyes may induce other severe but rare contact allergies, including neck and facial swelling and angioedema ( Table 3 ). 61 − 63 Angioedema is a type I hypersensitivity reaction characterized by edema of the skin and subcutaneous tissues that damages the airways and gastrointestinal tract and may even lead to life-threatening laryngeal swelling.…”

Section: Hair Dye-induced Toxicities and Adverse Health Effectsmentioning

confidence: 99%

“…Although exposure to aromatic amines (such as PPD) may give rise to the occurrence of lupus, several studies collectively confirm an insignificant association between the use of hair dyes containing PPD and the increased risk of SLE. − Nevertheless, skin exposure to hair dyes may induce other severe but rare contact allergies, including neck and facial swelling and angioedema (Table ). − Angioedema is a type I hypersensitivity reaction characterized by edema of the skin and subcutaneous tissues that damages the airways and gastrointestinal tract and may even lead to life-threatening laryngeal swelling.…”

Section: Hair Dye-induced Toxicities and Adverse Health Effectsmentioning

confidence: 99%

Hair Dye Ingredients and Potential Health Risks from Exposure to Hair Dyeing

Michailidou

Gahlon

Zeng

2022

Chem. Res. Toxicol.

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Given the worldwide popularity of hair dyeing, there is an urgent need to understand the toxicities and risks associated with exposure to chemicals found in hair dye formulations. Hair dyes are categorized as oxidative and nonoxidative in terms of their chemical composition and ingredients. For several decades, the expert panel’s Cosmetic Ingredient Review (CIR) has assessed the safety of many of the chemicals used in hair dyes; however, a comprehensive review of hair dye ingredients and the risk of exposure to hair dyeing has not been documented. Herein, we review the safety of the various chemicals in oxidative and nonoxidative hair dyes, toxicities associated with hair dyeing, and the carcinogenic risks related to hair dyeing. While many compounds are considered safe for users at the concentrations in hair dyes, there are conflicting data about a large number of hair dye formulations. The CIR expert panel has ratified a number of coloring ingredients for hair dyes and banned a series of chemicals as carcinogenic to animals and unsafe for this application. The use of these chemicals as raw materials for producing hair dyes may result in the synthesis of other contaminants with potential toxicities and increased risk of carcinogenesis. It is an open question whether personal or occupational hair dyeing increases the risk of cancer; however, in specific subpopulations, a positive association between hair dye use and cancer occurrence has been reported. To address this question, a better understanding of the chemical and mechanistic basis of the reported toxicities of hair dye mixtures and individual hair dye ingredients is needed. It is anticipated that in-depth chemical and systems toxicology studies harnessing modern and emerging techniques can shed light on this public health concern in the future.

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Severe facial swelling in a pregnant woman after using hair dye

Cited by 6 publications

References 8 publications

Presentations to emergency departments in Melbourne, Australia diagnosed as allergic contact dermatitis

Presentations to emergency departments in Melbourne, Australia diagnosed as allergic contact dermatitis

Allergic Contact Dermatitis and Concomitant Dermatologic Diseases: A Retrospective Study

Hair Dye Ingredients and Potential Health Risks from Exposure to Hair Dyeing

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