Severe Fever with Thrombocytopenia Syndrome Presenting with Hemophagocytic Lymphohistiocytosis

Lee, Jongmin; Jeong, Gyeongmin; Lim, Jung Hyun; Kim, Hawk; Park, Sun Whan; Lee, Won Ja; Jun, Jae Bum

doi:10.3947/ic.2016.48.4.338

Cited by 11 publications

(2 citation statements)

References 9 publications

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“…24,25 Meanwhile, cytokine storm can contribute to hemophagocytic lymphohistiocytosis (HLH). 4,26 Takahashi et al reported that five SFTS patients who underwent bone marrow aspirate, all exhibited hemophagocytosis which was also observed in lymph nodes and spleen. 4 Jung et al suggested SFTS cases complicated by HLH have a worse prognosis.…”

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confidence: 99%

Risk Factors and Clinical Characteristics of Severe Fever with Thrombocytopenia Syndrome

Wang¹,

Wu²,

Jiao³

et al. 2020

IJGM

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This study was to investigate the clinical characteristics and laboratory parameters of severe fever with thrombocytopenia syndrome (SFTS). Patients and Methods: A detailed retrospective analysis of clinical records for SFTS patients was conducted. Fifty-one cases confirmed SFTS virus infected were enrolled. The clinical characteristics and laboratory parameters between survivors and non-survivors were analyzed. Results: All patients aged between 30 and 80 years were farmers or residing in wooded and hilly areas. All patients occurred between April and October. The major clinical manifestations were fever, fatigue, diarrhea, myalgia, nausea and vomiting. Conscious disturbance, lymph node enlargement and hemorrhage were common. Fatal outcome occurred in 31.4% (16/51) of patients. Compared with survivors group, in non-survivors group, the proportion of consciousness disturbance, age, the levels of AST, LDH, Bun, Cr, PT and APTT were significantly increased, and PLT was significantly decreased. The age, PLT, AST, LDH, Cr, PT and APTT were the risk factors for fatal outcomes. Moreover, the age (OR, 1.245; 95% CI, 1.052-1.474) and APTT (OR, 1.095; 95% CI, 1.005-1.192) were the independent risk factors for fatal outcomes. Heteromorphic lymphocyte and hemophagocytosis could be found in SFTS patients, especially the proportion of finding hemophagocytosis was significantly higher in non-survivors group compared with survivors group. Conclusion:These results suggest SFTS is a systemic infection, the age and APTT can be used as potential predictors referring to severe SFTS cases.

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confidence: 99%

Risk Factors and Clinical Characteristics of Severe Fever with Thrombocytopenia Syndrome

Wang¹,

Wu²,

Jiao³

et al. 2020

IJGM

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“…Patients with severe SFTS might experience hemophagocytic lymphohistiocytosis, which associated with cytokine storm ( Lee et al., 2016 ; Oh et al., 2016 ; Nakano et al., 2017 ; Kaneko et al., 2018 ; Kim et al., 2018 ; Jung et al., 2019). Hemophagocytic lymphohistiocytosis was characterized by persistent activation of CTLs, NK cells, and macrophages and was often accompanied with uncontrolled abnormal secretion of inflammatory cytokines, resulting in systemic inflammatory symptoms and signs ( Al-Samkari and Berliner, 2018 ).…”

Section: Host Immune Responsementioning

confidence: 99%

The Endless Wars: Severe Fever With Thrombocytopenia Syndrome Virus, Host Immune and Genetic Factors

Wang

Tan

et al. 2022

Front. Cell. Infect. Microbiol.

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging arboviral infectious disease with a high rate of lethality in susceptible humans and caused by severe fever with thrombocytopenia syndrome bunyavirus (SFTSV). Currently, neither vaccine nor specific antiviral drugs are available. In recent years, given the fact that both the number of SFTS cases and epidemic regions are increasing year by year, SFTS has become a public health problem. SFTSV can be internalized into host cells through the interaction between SFTSV glycoproteins and cell receptors and can activate the host immune system to trigger antiviral immune response. However, SFTSV has evolved multiple strategies to manipulate host factors to create an optimal environment for itself. Not to be discounted, host genetic factors may be operative also in the never-ending winning or losing wars. Therefore, the identifications of SFTSV, host immune and genetic factors, and their interactions are critical for understanding the pathogenic mechanisms of SFTSV infection. This review summarizes the updated pathogenesis of SFTS with regard to virus, host immune response, and host genetic factors to provide some novel perspectives of the prevention, treatment, as well as drug and vaccine developments.

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Cytokine Storm Syndrome Associated with Hemorrhagic Fever and Other Viruses

Sen

Ramanan

2019

Cytokine Storm Syndrome

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Severe Fever with Thrombocytopenia Syndrome Presenting with Hemophagocytic Lymphohistiocytosis

Cited by 11 publications

References 9 publications

Risk Factors and Clinical Characteristics of Severe Fever with Thrombocytopenia Syndrome

Risk Factors and Clinical Characteristics of Severe Fever with Thrombocytopenia Syndrome

The Endless Wars: Severe Fever With Thrombocytopenia Syndrome Virus, Host Immune and Genetic Factors

Cytokine Storm Syndrome Associated with Hemorrhagic Fever and Other Viruses

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