Severe fever with thrombocytopenia syndrome and its pathogen SFTSV

Lei, Xiao Ying; Liu, Miaomiao; Yu, Xue Jie

doi:10.1016/j.micinf.2014.12.002

Cited by 69 publications

(59 citation statements)

References 53 publications

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“…Our results demonstrated that 52.4% of the confirmed SFTS cases were individuals over 60 years old in eastern China, consistent with the data from the earlier studies in other SFTS-endemic areas 19, 23 . Likewise, SFTSV were more pathogenic to older people, as over 80% of the fatal SFTS cases were the population over 60 years old as shown in our report (Table 1).…”

Section: Discussionsupporting

confidence: 92%

Increased Prevalence of Severe Fever with Thrombocytopenia Syndrome in Eastern China Clustered with Multiple Genotypes and Reasserted Virus during 2010–2015

Cui

et al. 2017

Sci Rep

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Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne viral disease with high mortality. Since January 2010, we have conducted an epidemiological surveillance and etiological study of SFTS in Jiangsu and Anhui provinces. From January 2010 through December 2015, a total of 286 SFTS cases were confirmed in Jiangsu and Anhui provinces with a case fatality rate of 16.1%. The majority of confirmed SFTS cases were distributed in the border area of Jiangsu and Anhui provinces. Our findings suggest that the SFTS prevalence rate rose since 2010 and reached its highest in 2015. Phylogenetic analysis demonstrated that the majority of the SFTSV strains (83.6%) from Jiangsu and Anhui provinces belonged to genotypes A and D. Notably, we identified three strains of SFTSV clustered into the genotype E. This is the first report of the genotype E SFTSV strains in mainland of China. A reassortment between genotype A and D was found in the central region of the endemic areas, where three SFTSV genotypes (A, C and D) were co-circulating.

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Section: Discussionsupporting

confidence: 92%

Increased Prevalence of Severe Fever with Thrombocytopenia Syndrome in Eastern China Clustered with Multiple Genotypes and Reasserted Virus during 2010–2015

Cui

et al. 2017

Sci Rep

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“…Arguably the most prominent is the severe fever with thrombocytopenia syndrome virus (SFTSV), identified following local outbreaks of a febrile disease with high mortality rates in several provinces of China during 2009–2011 [12]. SFTSV cases or exposure has also been documented in South Korea and Japan; and Haemaphysalis longicornis ticks were suggested as the primary transmission vector [13, 14]. Another novel virus, the Heartland virus (HRTV), vectored via Amblyomma americanum ticks, has been characterized in human cases of febrile disease in the USA [15, 16].…”

Section: Introductionmentioning

confidence: 99%

Generic amplification and next generation sequencing reveal Crimean-Congo hemorrhagic fever virus AP92-like strain and distinct tick phleboviruses in Anatolia, Turkey

et al. 2017

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BackgroundTicks are involved with the transmission of several viruses with significant health impact. As incidences of tick-borne viral infections are rising, several novel and divergent tick- associated viruses have recently been documented to exist and circulate worldwide. This study was performed as a cross-sectional screening for all major tick-borne viruses in several regions in Turkey. Next generation sequencing (NGS) was employed for virus genome characterization. Ticks were collected at 43 locations in 14 provinces across the Aegean, Thrace, Mediterranean, Black Sea, central, southern and eastern regions of Anatolia during 2014–2016. Following morphological identification, ticks were pooled and analysed via generic nucleic acid amplification of the viruses belonging to the genera Flavivirus, Nairovirus and Phlebovirus of the families Flaviviridae and Bunyaviridae, followed by sequencing and NGS in selected specimens.ResultsA total of 814 specimens, comprising 13 tick species, were collected and evaluated in 187 pools. Nairovirus and phlebovirus assays were positive in 6 (3.2%) and 48 (25.6%) pools. All nairovirus sequences were closely-related to the Crimean-Congo hemorrhagic fever virus (CCHFV) strain AP92 and formed a phylogenetically distinct cluster among related strains. Major portions of the CCHFV genomic segments were obtained via NGS. Phlebovirus sequencing revealed several tick-associated virus clades, including previously-characterized Antigone, Lesvos, KarMa and Bole tick viruses, as well as a novel clade. A wider host range for tick-associated virus strains has been observed. NGS provided near-complete sequences of the L genomic segments of Antigone and KarMa clades, as well as Antigone partial S segment. Co- infections of CCHFV and KarMa or novel phlebovirus clades were detected in 2.1% of the specimens.ConclusionsWidespread circulation of various tick-associated phlebovirus clades were documented for the first time in Anatolia. Genomes of CCHFV AP92 strains were identified in previously unexplored locations. NGS provided the most detailed genomic characterization of the Antigone and KarMa viruses to date. The epidemiological and health-related consequences must be elucidated.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-017-2279-1) contains supplementary material, which is available to authorized users.

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“…Examples in which next-generation sequencing methods have identified novel viral agents associated with disease outbreaks include severe fever with thrombocytopenia virus (SFTV) in China ( 3 ), a bunyavirus in the United States ( 4 ), and a novel rhabdovirus in Central Africa ( 5 ). Using such methods, 2 authors of this study (A.K.…”

mentioning

confidence: 99%

Evaluation of Viremia Frequencies of a Novel Human Pegivirus by Using Bioinformatic Screening and PCR

Bonsall¹,

Gregory²,

Ip³

et al. 2016

Emerg. Infect. Dis.

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Severe fever with thrombocytopenia syndrome and its pathogen SFTSV

Cited by 69 publications

References 53 publications

Increased Prevalence of Severe Fever with Thrombocytopenia Syndrome in Eastern China Clustered with Multiple Genotypes and Reasserted Virus during 2010–2015

Increased Prevalence of Severe Fever with Thrombocytopenia Syndrome in Eastern China Clustered with Multiple Genotypes and Reasserted Virus during 2010–2015

Generic amplification and next generation sequencing reveal Crimean-Congo hemorrhagic fever virus AP92-like strain and distinct tick phleboviruses in Anatolia, Turkey

Evaluation of Viremia Frequencies of a Novel Human Pegivirus by Using Bioinformatic Screening and PCR

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