Severe Fever with Thrombocytopenia Syndrome Virus Infection, South Korea, 2010

Kim, Young Ree; Yun, Yeo-Jun; Bae, Seung Geon; Park, Dahee; Kim, Suhyun; Lee, Jae Myun; Cho, Nam Hyuk; Kim, Yang Soo; Lee, Keun Hwa

doi:10.3201/eid2411.170756

Cited by 76 publications

(53 citation statements)

References 9 publications

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“…The disease was first identified in China in 2009 but retrospectively traced back to human cases in 2007 [3,4]. South Korea and Japan both reported their first cases in 2013, and were traced retrospectively to 2010 in South Korea [5][6][7]. Tick-to-human transmission is the primary route by which people are infected with SFTSV, and Haemaphysalis longicornis (H. longicornis) ticks act as the main transmission vector [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Mapping the global potential transmission hotspots for severe fever with thrombocytopenia syndrome by machine learning methods

Miao

Dai

Zhao

et al. 2020

Emerging Microbes & Infections

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with increasing spread. Currently SFTS transmission has expanded beyond Asian countries, however, with definitive global extents and risk patterns remained obscure. Here we established an exhaustive database that included globally reported locations of human SFTS cases and the competent vector, Haemaphysalis longicornis (H. longicornis), as well as the explanatory environmental variables, based on which, the potential geographic range of H. longicornis and risk areas for SFTS were mapped by applying two machine learning methods. Ten predictors were identified contributing to global distribution for H. longicornis with relative contribution ≥1%. Outside contemporary known distribution, we predict high receptivity to H. longicornis across two continents, including northeastern USA, New Zealand, parts of Australia, and several Pacific islands. Eight key drivers of SFTS cases occurrence were identified, including elevation, predicted probability of H. longicornis presence, two temperature-related factors, two precipitation-related factors, the richness of mammals and percentage coverage of water bodies. The globally model-predicted risk map of human SFTS occurrence was created and validated effective for discriminating the actual affected and unaffected areas (median predictive probability 0.74 vs. 0.04, P < 0.001) in three countries with reported cases outside China. The high-risk areas (probability ≥50%) were predicted mainly in east-central China, most parts of the Korean peninsula and southern Japan, and northern New Zealand. Our findings highlight areas where an intensive vigilance for potential SFTS spread or invasion events should be advocated, owing to their high receptibility to H. longicornis distribution.

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Section: Introductionmentioning

confidence: 99%

Mapping the global potential transmission hotspots for severe fever with thrombocytopenia syndrome by machine learning methods

Miao

Dai

Zhao

et al. 2020

Emerging Microbes & Infections

View full text Add to dashboard Cite

show abstract

“…The causative agent, SFTS virus (SFTSV), renamed Huaiyangshan banyangvirus of the order Bunyavirales (family Phenuiviridae, genus Banyangvirus), is transmitted by ticks and is closely related to Heartland virus (HRTV), which is endemic in eastern regions of the United States [4,5]. First discovered in China in 2009, SFTSV has also emerged in South Korea, Japan and Vietnam [6][7][8][9]. There are no licensed vaccines or antiviral compounds approved to prevent or treat SFTSV infection.…”

Section: Introductionmentioning

confidence: 99%

Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice

et al. 2019

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever (VHF) endemic to China, South Korea, Japan, and Vietnam. Here we characterize the pathogenesis and natural history of disease in IFNAR-/- mice challenged with the HB29 strain of SFTS virus (SFTSV) and demonstrate hallmark features of VHF such as vascular leak and high concentrations of proinflammatory cytokines in blood and tissues. Treatment with FX06, a natural plasmin digest product of fibrin in clinical development as a treatment for vascular leak, reduced vascular permeability associated with SFTSV infection but did not significantly improve survival outcome. Further studies are needed to assess the role of vascular compromise in the SFTS disease process modeled in IFNAR-/- mice.

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“…SFTSV was identified in 2009 in the Hubei and Henan provinces in eastern China when several patients presented with febrile illness similar to anaplasmosis, a tickborne rickettsial disease [2]. Following its isolation and initial characterization, human cases of SFTSV were subsequently reported in South Korea [3][4][5], and Japan [6]. Most recently, samples from patients in Vietnam suggested endemic SFTSV [7].…”

Section: Severe Fever With Thrombocytopenia Syndrome Virus (Sftsv)mentioning

confidence: 99%

Immune Modulation and Immune-Mediated Pathogenesis of Emerging Tickborne Banyangviruses

2019

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In the last decade, the emergence of several, novel tickborne viruses have caused significant disease in humans. Of interest are the tickborne banyangviruses: Severe fever with thrombocytopenia syndrome virus (SFTSV), Heartland virus (HRTV), and Guertu virus (GTV). SFTSV and HRTV infection in humans cause viral hemorrhagic fever-like disease leading to mortality rates ranging from 6–30% of the cases. The systemic inflammatory response syndrome (SIRS) associated with SFTSV infection is hypothesized to contribute significantly to pathology seen in patients. Despite the severe disease caused by HRTV and SFTSV, there are no approved therapeutics or vaccines. Investigation of the immune response during and following infection is critical to the generation of fully protective vaccines and/or supportive treatments, and overall understanding of viral immune evasion mechanisms may aid in the development of a new class of therapeutics.

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Severe Fever with Thrombocytopenia Syndrome Virus Infection, South Korea, 2010

Cited by 76 publications

References 9 publications

Mapping the global potential transmission hotspots for severe fever with thrombocytopenia syndrome by machine learning methods

Mapping the global potential transmission hotspots for severe fever with thrombocytopenia syndrome by machine learning methods

Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice

Immune Modulation and Immune-Mediated Pathogenesis of Emerging Tickborne Banyangviruses

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