Severe food-induced vasculitis in two children

Businco, L; Falconieri, P.; Bellioni-Businco, Barbara; Bahna, Sami L.

doi:10.1034/j.1399-3038.2002.00097.x

Cited by 16 publications

(4 citation statements)

References 17 publications

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“…However, food anaphylaxis patients are at rare risk of atopic vasculitis. Given COVID-19-associated vasculitis affiliation, a low clinical threshold to identify vasculitis is advised [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Immune Response to SARS-CoV-2 in an Asymptomatic Pediatric Allergic Cohort

Marsteller

Fregoso²,

Morphew

et al. 2021

Antibodies

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Disease-specific COVID-19 pediatric comorbidity has not been studied effectively to date. Atopy and food anaphylaxis disease states require improved characterization of SARS-CoV-2 infection risk. To provide the first such characterization, we assessed serum samples of a highly atopic, food anaphylactic, asymptomatic pediatric cohort from across the US during the height of the pandemic. From our biobank, 172 pediatric patient serum samples were characterized specific to atopic, food anaphylactic, and immunologic markers in the US at the beginning of the pandemic, from 1 February to 20 April 2020. Clinical and demographic data were further analyzed in addition to sample analysis for SARS-CoV-2 IgM and IgG ELISA. SARS-CoV-2 antibody results were positive in six patients (4%). Nearly half of the pediatric patients had a history of asthma (49%). Total IgE, total IgG, and IgG1-3 were similar in those positive and negative to SARS-CoV-2. Median total IgG4 in the SARS-CoV-2 positive group was nearly three times (p-value = 0.02) that of the negative group. Atopy controller medications did not confer additional benefit. Our data suggest that food anaphylaxis and highly atopic children are not at increased risk for SARS-CoV-2 seropositivity. This specific population appears either at equal or potentially less risk than the general population. Total and specific IgG4 may be a novel predictor of SARS-CoV-2 infection risk specific to the allergic pediatric population.

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Section: Discussionmentioning

confidence: 99%

Immune Response to SARS-CoV-2 in an Asymptomatic Pediatric Allergic Cohort

Marsteller

Fregoso²,

Morphew

et al. 2021

Antibodies

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“…For instance, variations in the composition and function of the gut microbiota have been associated with obesity and metabolic diseases, and dysbiosis has been implicated in the pathogenesis of IBD. Inflammation brought on by dysbiosis may potentially have an effect on cardiovascular health [36]. Polymyalgia rheumatica (PMR) is one of the types of inflammatory disorders that mostly affects individuals aged over 50.…”

Section: Composition Of Gut Microbial Floramentioning

confidence: 99%

Dietary Implications of the Bidirectional Relationship between the Gut Microflora and Inflammatory Diseases with Special Emphasis on Irritable Bowel Disease: Current and Future Perspective

et al. 2023

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The immune system is vital for safeguarding the human body against infections and inflammatory diseases. The role of diet and meal patterns in modulating immune function is complex, and highlighting this topic is crucial for identifying potential ways to improve immune health. In Europe, the Mediterranean diet and Western diet are the most common dietary patterns, and gaining an understanding of how they affect immune function is essential for public health. There are numerous inflammatory diseases that are observed in younger and older people. Some of the common diseases include polymyalgia rheumatica (PMR), spinal muscular atrophy (SMA), vasculitis, sarcopenia, cirrhosis, cancer, and fibromyalgia, but the main focus in this review article is on irritable bowel disease (IBD). In general, dietary choices can have an immense impact on the microbial flora of the gut in people with inflammatory diseases. The intake of Mediterranean-style foods promotes the growth of healthy bacteria that enhances the function of the immune system. On the other hand, it is mostly seen that the intake of Western-style foods leads to the growth of harmful gut bacteria that contributes to inflammation and disease development by weakening the immune system. Additionally, inflammation in the gut can impact brain function, leading to mood disorders, such as anxiety and depression. Rare inflammatory diseases, such as psoriasis and sarcoidosis, are of main interest in this article. All the above-mentioned common and rare inflammatory diseases have a certain relationship with the microbiota of the gut. The gut microbiome plays a significant role in IBD; fiber and prebiotic interventions may represent promising adjunct therapies for pediatric IBD by targeting the gut microbiome. By advancing a good overall arrangement of microorganisms in the stomach through dietary mediations, working on the side effects and alleviating of diseases might be conceivable. The gut microbiota can be affected differently by various dietary fatty acid types. There is also an involvement of genetics in the progression of IBD, such as transcriptional factors, and one gene of interest is the LCT gene, which encodes for lactase, an enzyme responsible for digesting lactose in the gut.

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“…Few studies remark negative action on strength of lower esophageal sphincter (LES): ingestion of cocoas seems to decrease LES pressure, thus worsening gastroesophageal reflux [97]. Moreover, chocolate has been related to allergic reactions as dermatitis and food-induced vasculitis in children [98,99].…”

Section: Negative Effects Of Cocoa Consumptionmentioning

confidence: 99%

Cacao as a Globalised Functional Food: Review on Cardiovascular Effects of Chocolate Consumption

Valussi¹,

Minto²

2016

TOASJ

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Polyphenols have increasingly been studied for their influence on cardiometabolic health. Since cacao and chocolate can be a rich source of polyphenols, they too have been investigated for their supposed health benefits. In the first part of this paper the history of the food and medicinal uses of the cacao plant was briefly examined. A particular emphasis has been placed on the analysis of the process of transformation of the cacao seed into chocolate, since many of the processing steps involved have important consequences on the final product’s content in polyphenols and flavanols, and hence on the purported beneficial activity of chocolate. This evaluation is also of great importance in interpreting the results of the epidemiological and clinical studies. The relevant literature was surveyed in the second part of the paper, and the results for the consumption of polyphenol-rich chocolate are that it is well correlated to a reduction of the overall cardiovascular risk, and of arterial blood pressure in hypertensive subjects. Less corroborated are the positive effects on vascular endothelial health, on blood lipids and on lipid peroxidation. There are also preliminary but promising results for a positive action on insulin sensitivity, platelet function and inflammation. It remains to be seen whether and how these results can be translated into pragmatic guidelines on the health benefits of the consumption of commercial chocolate bars or products.

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Severe food-induced vasculitis in two children

Cited by 16 publications

References 17 publications

Immune Response to SARS-CoV-2 in an Asymptomatic Pediatric Allergic Cohort

Immune Response to SARS-CoV-2 in an Asymptomatic Pediatric Allergic Cohort

Dietary Implications of the Bidirectional Relationship between the Gut Microflora and Inflammatory Diseases with Special Emphasis on Irritable Bowel Disease: Current and Future Perspective

Cacao as a Globalised Functional Food: Review on Cardiovascular Effects of Chocolate Consumption

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