Severe Gastroparesis Flare: Is COVID-19 the Inciting Factor?

Patel, Aditya; Ali, Ruhma; Hussain, Muhammad; Slim, Jihad; Dacosta, Theodore

doi:10.14740/jmc3883

Cited by 5 publications

(14 citation statements)

References 20 publications

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“…Preclinical studies demonstrated the ability of aqueous extract of C. cassia Presl bark (150 and 300 mg/kg) to enhance gastric emptying and to promote GI transit that are both delayed in some Long COVID‐19 patients, suffering from a complex pathological picture‐defined autoimmune GI dysmotility (Montalvo et al, 2022; Sebai et al, 2019). These effects may be relevant also in patients with SARS‐CoV‐2‐induced gastric motility alterations (Patel et al, 2022; Rusch et al, 2022). Furthermore, in vivo experiments have shown that water extracts derived from the bark of C. cassia (150 mg/kg) significantly reduce the extent of gastric mucosa injuries caused by indomethacin, NSAIDs, ethanol, and ethanol/hydrochloric acid.…”

Section: The Phytocomplexmentioning

confidence: 99%

Long COVID‐19 gastrointestinal related disorders and traditional Chinese medicine: A network target‐based approach

Mattioli,

Frosini,

Corazza

et al. 2024

Phytotherapy Research

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The significant number of individuals impacted by the pandemic makes prolonged symptoms after COVID‐19 a matter of considerable concern. These are numerous and affect multiple organ systems. According to the World Health Organization (WHO), prolonged gastrointestinal issues are a crucial part of post‐COVID‐19 syndrome. The resulting disruption of homeostasis underscores the need for a therapeutic approach based on compounds that can simultaneously affect more than one target/node. The present review aimed to check for nutraceuticals possessing multiple molecular mechanisms helpful in relieving Long COVID‐19‐specific gastrointestinal symptoms. Specific plants used in Keywords Chinese Medicine (TCM) expected to be included in the WHO Global Medical Compendium were selected based on the following criteria: (1) they are widely used in the Western world as natural remedies and complementary medicine adjuvants; (2) their import and trade are regulated by specific laws that ensure quality and safety (3) have the potential to be beneficial in alleviating intestinal issues associated with Long COVID‐19. Searches were performed in PubMed, Elsevier, Google Scholar, Scopus, Science Direct, and ResearchGate up to 2023. Cinnamomum cassia, Glycyrrhiza uralensis, Magnolia officinalis, Poria cocos, Salvia miltiorrhiza, Scutellaria baicalensis, and Zingiber officinalis were identified as the most promising for their potential impact on inflammation and oxidative stress. Based on the molecular mechanisms of the phytocomplexes and isolated compounds of the considered plants, their clinical use may lead to benefits in gastrointestinal diseases associated with Long COVID‐19, thanks to a multiorgan and multitarget approach.

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Section: The Phytocomplexmentioning

confidence: 99%

Long COVID‐19 gastrointestinal related disorders and traditional Chinese medicine: A network target‐based approach

Mattioli,

Frosini,

Corazza

et al. 2024

Phytotherapy Research

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“…Пациентку выписали из стационара на 11-й день с 2-недельным курсом антикоагулянтной терапии и метоклопрамида. При повторном визите к гастроэнтерологу пациентка сообщила об улучшении состояния [72].…”

Section: постковидное поражение пищеварительной систему у пациентов с сдunclassified

Characteristics of digestive system lesions in patients with diabetes mellitus

Chentsov

Kokovina

Асланов

et al. 2023

jour

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Lesions of the digestive system in diabetes mellitus (DM) are of secondary nature and arise due to autonomic neuropathy. As a result of hyperglycemia, lesions of the esophagus, stomach, small and large intestine develop. The most common disorder of the digestive system in diabetes is gastroparesis. The diagnosis of gastroparesis is currently insufficient. It is connected with low awareness and, as a consequence, rare visit of patients to specialists, and also with similarity of clinical symptoms with other functional disorders of gastrointestinal tract (GIT). The main risk factors for gastroparesis are hyperglycemia, smoking, alcohol, and certain medications. Most patients with gastroparesis suffer from depression and increased anxiety. Taking medications to treat depression negatively affects the function of the digestive system. This problem interferes with patients’ quality of life. During the pandemic of coronavirus infection, the number of patients seeking medical care due to exacerbation of gastrointestinal disorders increased. The question of etiology is subject to further study. This review also considers the effect of cholecystectomy on the development of gastroparesis in these patients. These patients need special monitoring of glucose levels to prescribe timely antidiabetic therapy and prevent future gastroparesis. For the treatment of lesions of the digestive system in diabetes mellitus, a special diet, in particular the exclusion of hard-to-digest fiber, fatty foods, inclusion of vitamin complexes and normalization of the microbiota plays a paramount role. The main therapeutic value is the timely diagnosis and normalization of glucose levels.

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“…A partir de dezembro de 2019 a infecção por SARS-CoV-2 começou a se espalhar rapidamente causando uma pandemia com grande morbidade e mortalidade, e grande impacto a sistemas de saúde ao redor do mundo (Chen et al, 2021). A doença causada por este patógeno foi chamada de COVID-19 e considerada inicialmente uma doença respiratória, causando desde sintomas de resfriado moderado a pneumonia viral grave (Chen et al, 2021;Patel et al, 2022;Song et al, 2021). Com melhor entendimento da doença, percebeu-se que outros sistemas podem ser afetados, podendo haver manifestações neurológicas, renais, cardiológicas, hematopoiéticas e gastrointestinais (Chen et al, 2021;Patel et al, 2022;Deb et al, 2022;Gubatan et al, 2022).…”

Section: Introductionunclassified

“…A doença causada por este patógeno foi chamada de COVID-19 e considerada inicialmente uma doença respiratória, causando desde sintomas de resfriado moderado a pneumonia viral grave (Chen et al, 2021;Patel et al, 2022;Song et al, 2021). Com melhor entendimento da doença, percebeu-se que outros sistemas podem ser afetados, podendo haver manifestações neurológicas, renais, cardiológicas, hematopoiéticas e gastrointestinais (Chen et al, 2021;Patel et al, 2022;Deb et al, 2022;Gubatan et al, 2022). Cerca de metade dos pacientes infectados por SARS-CoV-2 apresentam sintomas gastrointestinais durante a fase aguda, como diarreia (manifestação mais comum), náuseas, vômitos e dor abdominal (Deb et al, 2022;Gubatan et al, 2022;Silva et al, 2020).…”

Section: Introductionunclassified

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Post-COVID refractory gastroparesis: a case report

Oliveira,

Ibiapina,

Reis

et al. 2023

CLIUM

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Introduction: COVID-19 is a disease caused by the SARS-CoV-2 virus, which triggered a pandemic with major repercussions for the world's health systems. About half of patients experience gastrointestinal symptoms, but gastroparesis after SARS-CoV-2 infection is a rare and generally self-limiting condition. Objective: To describe a clinical case of gastroparesis after SARS-CoV-2 infection that required surgical intervention. Result: This is a rare condition, with few reports, generally self-limiting. There are no reports of other refractory conditions requiring surgical intervention. Conclusion: The COVID-19 pandemic resulted in a large number of patients infected with SARS-CoV-2. Because the virus has gastrointestinal tropism, doctors must be aware of possible clinical manifestations in these patients.

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Severe Gastroparesis Flare: Is COVID-19 the Inciting Factor?

Cited by 5 publications

References 20 publications

Long COVID‐19 gastrointestinal related disorders and traditional Chinese medicine: A network target‐based approach

Long COVID‐19 gastrointestinal related disorders and traditional Chinese medicine: A network target‐based approach

Characteristics of digestive system lesions in patients with diabetes mellitus

Post-COVID refractory gastroparesis: a case report

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