Severe Glyphosate‐Surfactant Intoxication Successfully Treated With Continuous Hemodiafiltration and Direct Hemoperfusion: Case Report

Ozaki, Taro; Sofue, Tadashi; Kuroda, Yasuhiro

doi:10.1111/1744-9987.12565

Cited by 8 publications

(10 citation statements)

References 4 publications

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“…The patient was detoxified using continuous hemofiltration and direct hemoperfusion. 165 Moreover, persistent ventricular tachycardia and metabolic acidosis developed in a 47-year-old GLP-SH-poisoned man who recovered after extracorporeal membrane oxygenation was applied within 4 h of the cardiopulmonary collapse. 166 Similarly, a 52-year-old man, intoxicated with GLP-POEA, experienced circulatory shock and refractory hypotension.…”

Section: Preclinical Studies Of Glp Impact On the Endocrine And Repro...mentioning

confidence: 99%

“…The intoxication symptoms included increased creatinine levels, acute kidney injury, hemoconcentration, bicarbonate and lactate acidosis, and pneumonitis. The patient was detoxified using continuous hemofiltration and direct hemoperfusion . Moreover, persistent ventricular tachycardia and metabolic acidosis developed in a 47-year-old GLP-SH-poisoned man who recovered after extracorporeal membrane oxygenation was applied within 4 h of the cardiopulmonary collapse .…”

Section: Glyphosate Toxicity To the Liver Kidneys And Endocrine Repro...mentioning

confidence: 99%

“…They are mainly used for the toxicological determination and degradation of GLP in the blood and urine. Emergency treatment of acute GBH intoxication involves HDF- or DHP-assisted gastric lavage with a large amount of normal saline followed by active charcoal administration . Further detoxification includes charcoal hemoperfusion and pulse therapies of cyclophosphamide and methylprednisolone, followed by dexamethasone application.…”

Section: Theranostics Of Glyphosate Intoxicationmentioning

confidence: 99%

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Glyphosate: Hepatotoxicity, Nephrotoxicity, Hemotoxicity, Carcinogenicity, and Clinical Cases of Endocrine, Reproductive, Cardiovascular, and Pulmonary System Intoxication

Mazuryk,

Klepacka,

Kutner

et al. 2024

ACS Pharmacol. Transl. Sci.

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Glyphosate (GLP) is an active agent of GLP-based herbicides (GBHs), i.e., broad-spectrum and postemergent weedkillers, commercialized by Monsanto as, e.g., Roundup and RangerPro formulants. The GBH crop spraying, dedicated to genetically engineered GLP-resistant crops, has revolutionized modern agriculture by increasing the production yield. However, abusively administered GBHs' ingredients, e.g., GLP, polyoxyethyleneamine, and heavy metals, have polluted environmental and industrial areas far beyond farmlands, causing global contamination and life-threatening risk, which has led to the recent local bans of GBH use. Moreover, preclinical and clinical reports have demonstrated harmful impacts of GLP and other GBH ingredients on the gut microbiome, gastrointestinal tract, liver, kidney, and endocrine, as well as reproductive, and cardiopulmonary systems, whereas carcinogenicity of these herbicides remains controversial. Occupational exposure to GBH dysregulates the hypothalamic−pituitary−adrenal axis, responsible for steroidogenesis and endocrinal secretion, thus affecting hormonal homeostasis, functions of reproductive organs, and fertility. On the other hand, acute intoxication with GBH, characterized by dehydration, oliguria, paralytic ileus, as well as hypovolemic and cardiogenic shock, pulmonary edema, hyperkalemia, and metabolic acidosis, may occur fatally. As no antidote has been developed for GBH poisoning so far, the detoxification is mainly symptomatic and supportive and requires intensive care based on gastric lavage, extracorporeal blood filtering, and intravenous lipid emulsion infusion. The current review comprehensively discusses the molecular and physiological basics of the GLP-and/or GBH-induced diseases of the endocrine and reproductive systems, and cardiopulmonary-, nephro-, and hepatotoxicities, presented in recent preclinical studies and case reports on the accidental or intentional ingestions with the most popular GBHs. Finally, they briefly describe modern and future healthcare methods and tools for GLP detection, determination, and detoxification. Future electronically powered, decision-making, and user-friendly devices targeting major GLP/GBH's modes of actions, i.e., dysbiosis and the inhibition of AChE, shall enable self-handled or point-of-care professional-assisted evaluation of the harm followed with rapid capturing GBH xenobiotics in the body and precise determining the GBH pathology-associated biomarkers levels.

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Section: Preclinical Studies Of Glp Impact On the Endocrine And Repro...mentioning

confidence: 99%

Section: Glyphosate Toxicity To the Liver Kidneys And Endocrine Repro...mentioning

confidence: 99%

Section: Theranostics Of Glyphosate Intoxicationmentioning

confidence: 99%

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Glyphosate: Hepatotoxicity, Nephrotoxicity, Hemotoxicity, Carcinogenicity, and Clinical Cases of Endocrine, Reproductive, Cardiovascular, and Pulmonary System Intoxication

Mazuryk,

Klepacka,

Kutner

et al. 2024

ACS Pharmacol. Transl. Sci.

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“…Interestingly, these complications depend on the volume of GLP-SH ingested and not the type of surfactant ingredient of the GBH . Emergency treatment of those intoxications comprises gastric lavage followed by hemodiafiltration and direct hemoperfusion, enabling the removal of GLP-IPA (228 Da) and surfactants (over 500 Da), respectively . Intensive care is required in severe GLP-SH intoxication, including dehydration, oliguria, paralytic ileus, hypovolemic shock, cardiogenic shock, pulmonary edema, hyperkalemia, and metabolic acidosis. , …”

Section: Environmental and Human Toxicity Of Glyphosatementioning

confidence: 99%

Glyphosate Separating and Sensing for Precision Agriculture and Environmental Protection in the Era of Smart Materials

Mazuryk

Klepacka

Kutner

et al. 2023

Environ. Sci. Technol.

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The present article critically and comprehensively reviews the most recent reports on smart sensors for determining glyphosate (GLP), an active agent of GLP-based herbicides (GBHs) traditionally used in agriculture over the past decades. Commercialized in 1974, GBHs have now reached 350 million hectares of crops in over 140 countries with an annual turnover of 11 billion USD worldwide. However, rolling exploitation of GLP and GBHs in the last decades has led to environmental pollution, animal intoxication, bacterial resistance, and sustained occupational exposure of the herbicide of farm and companies' workers. Intoxication with these herbicides dysregulates the microbiomegut-brain axis, cholinergic neurotransmission, and endocrine system, causing paralytic ileus, hyperkalemia, oliguria, pulmonary edema, and cardiogenic shock. Precision agriculture, i.e., an (information technology)-enhanced approach to crop management, including a site-specific determination of agrochemicals, derives from the benefits of smart materials (SMs), data science, and nanosensors. Those typically feature fluorescent molecularly imprinted polymers or immunochemical aptamer artificial receptors integrated with electrochemical transducers. Fabricated as portable or wearable lab-on-chips, smartphones, and soft robotics and connected with SM-based devices that provide machine learning algorithms and online databases, they integrate, process, analyze, and interpret massive amounts of spatiotemporal data in a user-friendly and decision-making manner. Exploited for the ultrasensitive determination of toxins, including GLP, they will become practical tools in farmlands and point-of-care testing. Expectedly, smart sensors can be used for personalized diagnostics, real-time water, food, soil, and air quality monitoring, site-specific herbicide management, and crop control.

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“…Because GLP is photochemically and photophysically inactive, it cannot directly be determined using the most conventional optical methods. Similarly, only a limited number of studies concerned the impact of GLP on FRP , and AA polymerizations. − Because of the photochemical inertia of GLP, only its photopolymerizable derivatives, such as acrylated GLP, were used in UV-FRP. , GLP or GLP-based herbicide intoxication-induced health issues, highlighted in clinical case reports, relate to hyperkalemia, oliguria, acidosis, digestive system malfunctions, cardiogenic shock, respiratory diseases, as well as neurological, hepatic, and kidney disorders. − Hence, the construction of microfluidic nanomaterial-based adsorbents or sensors for rapid on-site GLP determination and degradation, especially in contaminated waters or body fluids, has become a challenge for analytical chemistry and materials science.…”

Section: Introductionmentioning

confidence: 99%

In-Capillary Photodeposition of Glyphosate-Containing Polyacrylamide Nanometer-Thick Films

Mazuryk

Klepacka

Piechowska

et al. 2022

ACS Appl. Polym. Mater.

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The present research reports on in-water, site-specific photodeposition of glyphosate (GLP)-containing polyacrylamide (PAA-GLP) nanometer-thick films (nanofilms) on an inner surface of fused silica (fused quartz) microcapillaries presilanized with trimethoxy(octen-7yl)silane (TMOS). TMOS was chosen because of the vinyl group presence in its structure, enabling its participation in the (UV light)activated free-radical polymerization (UV-FRP) after its immobilization on a fused silica surface. The photodeposition was conducted in an aqueous (H 2 O/ACN; 3:1, v/v) solution, using UV-FRP (λ = 365 nm) of the acrylamide (AA) functional monomer, the N,N′-methylenebis(acrylamide) (BAA) cross-linking monomer, GLP, and the azobisisobutyronitrile (AIBN) UV-FRP initiator. Acetonitrile (ACN) was used as the porogen and the solvent to dissolve monomers and GLP. Because of the micrometric diameters of microcapillaries, the silanization and photodeposition procedures were first optimized on fused silica slides. The introduction of TMOS, as well as the formation of PAA and PAA-GLP nanofilms, was determined using atomic force microscopy (AFM), scanning electron microscopy with energy-dispersive X-ray (SEM−EDX) spectroscopy, and confocal micro-Raman spectroscopy. Particularly, AFM and SEM−EDX measurements determined nanofilms' thickness and GLP content, respectively, whereas in-depth confocal (micro-Raman spectroscopy)-assisted imaging of PAA-and PAA-GLP-coated microcapillary inner surfaces confirmed the successful photodeposition. Moreover, we examined the GLP impact on polymer gelation by monitoring hydration in a hydrogel and a dried powder PAA-GLP. Our study demonstrated the usefulness of the in-capillary micro-Raman spectroscopy imaging and in-depth profiling of GLP-encapsulated PAA nanofilms. In the future, our simple and inexpensive procedure will enable the fabrication of polymer-based microfluidic chemosensors or adsorptive-separating devices for GLP detection, determination, and degradation.

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Severe Glyphosate‐Surfactant Intoxication Successfully Treated With Continuous Hemodiafiltration and Direct Hemoperfusion: Case Report

Cited by 8 publications

References 4 publications

Glyphosate: Hepatotoxicity, Nephrotoxicity, Hemotoxicity, Carcinogenicity, and Clinical Cases of Endocrine, Reproductive, Cardiovascular, and Pulmonary System Intoxication

Glyphosate: Hepatotoxicity, Nephrotoxicity, Hemotoxicity, Carcinogenicity, and Clinical Cases of Endocrine, Reproductive, Cardiovascular, and Pulmonary System Intoxication

Glyphosate Separating and Sensing for Precision Agriculture and Environmental Protection in the Era of Smart Materials

In-Capillary Photodeposition of Glyphosate-Containing Polyacrylamide Nanometer-Thick Films

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