Severe hemolytic anemia and skin reaction in a patient treated with imatinib

Arriba, J. J. de; Nerín, C.; García, Elena; Gómez-Aldaraví, L.; Vila, Beatriz Losada

doi:10.1093/annonc/mdg245

Cited by 14 publications

(3 citation statements)

References 4 publications

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“…Murine breast cancers fluctuate in size as a function of the menstrual cycle, thought likely a consequence of the periodic proliferation and apoptosis driven by the hormone flux [20]. Human tumors show increased proliferative activity as a function of the menstrual cycle [21], but measures of apoptosis remain unchanged [22]. …”

Section: Introductionmentioning

confidence: 99%

Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank

et al. 2014

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IntroductionOur efforts to prevent and treat breast cancer are significantly impeded by a lack of knowledge of the biology and developmental genetics of the normal mammary gland. In order to provide the specimens that will facilitate such an understanding, The Susan G. Komen for the Cure Tissue Bank at the IU Simon Cancer Center (KTB) was established. The KTB is, to our knowledge, the only biorepository in the world prospectively established to collect normal, healthy breast tissue from volunteer donors. As a first initiative toward a molecular understanding of the biology and developmental genetics of the normal mammary gland, the effect of the menstrual cycle and hormonal contraceptives on DNA expression in the normal breast epithelium was examined.MethodsUsing normal breast tissue from 20 premenopausal donors to KTB, the changes in the mRNA of the normal breast epithelium as a function of phase of the menstrual cycle and hormonal contraception were assayed using next-generation whole transcriptome sequencing (RNA-Seq).ResultsIn total, 255 genes representing 1.4% of all genes were deemed to have statistically significant differential expression between the two phases of the menstrual cycle. The overwhelming majority (221; 87%) of the genes have higher expression during the luteal phase. These data provide important insights into the processes occurring during each phase of the menstrual cycle. There was only a single gene significantly differentially expressed when comparing the epithelium of women using hormonal contraception to those in the luteal phase.ConclusionsWe have taken advantage of a unique research resource, the KTB, to complete the first-ever next-generation transcriptome sequencing of the epithelial compartment of 20 normal human breast specimens. This work has produced a comprehensive catalog of the differences in the expression of protein-coding genes as a function of the phase of the menstrual cycle. These data constitute the beginning of a reference data set of the normal mammary gland, which can be consulted for comparison with data developed from malignant specimens, or to mine the effects of the hormonal flux that occurs during the menstrual cycle.

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Section: Introductionmentioning

confidence: 99%

Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank

et al. 2014

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“…Both Coombs' positive and negative hemolytic anemia has been reported in patients taking imatinib [25,26]. In the latter, the patient responded to steroids and was able to continue imatinib for metastatic GIST.…”

Section: Other Hematologic Toxicitiesmentioning

confidence: 96%

Hematologic toxicities of small molecule tyrosine kinase inhibitors

2011

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Small molecule tyrosine kinase inhibitors (TKIs) are potent anti-cancer targeted therapies. TKIs are considered safe and efficacious therapeutic modalities, and are generally tolerated well. However, they are associated with certain side effects including hematologic toxicities such as anemia, macrocytosis, neutropenia, thrombocytopenia, hemolytic anemia, bone marrow aplasia and necrosis. Thrombotic microangiopathy, arterial thromboembolism and splenic infarction can also occur following treatment with TKIs. Cytopenias are the most common adverse effects associated with these agents, and other hematologic toxicities are not frequent. It is essential for clinicians to monitor patients closely, and recognize those side effects as early as possible, in order to improve efficacy of small molecule TKIs and optimize outcomes. This article summarizes hematologic toxicities associated with the commonly used small molecule TKIs. It also provides practical strategies for the management of these toxicities.

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“…Entonces, el 25% de las piezas publicadas arremetió contra el Gobierno, reprochándole que esta medida había hechos estragos en la bolsa (15). Entraban en contradicción con la línea editorial que la calificaba como 'decisión realista' que suponía un paso adelante en la democracia (16).…”

Section: Durante El Gobierno Suárez (1976-1977)unclassified

Arriba durante la Transición española: el abandono de su función propagandística con respecto al Gobierno

Fábregas

Romero-Domínguez

2014

Hist. Comun. Soc.

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ResumenDurante la transición española, se produjeron cambios políticos, sociales, ideológicos y periodísticos en el país que contribuyeron a que el diario Arriba, fundado por Falange Española y asimilado como órgano de propaganda por el régimen franquista durante la dictadura, evolucionara considerablemente. Pasó, así, gracias a la presencia de diferentes ideologías en su redacción, del apoyo al Gobierno, aún muy presente tras la muerte de Franco (noviembre de 1975), a la crítica hacia el mismo al fin de este período, el referéndum de la Constitución (diciembre de 1978).Palabras clave: historia del periodismo; prensa franquista; prensa del Movimiento; diario Arriba; transición española Arriba during the Spanish Transition: the abandonment of its propaganda function with respect to the Government Abstract During the Spanish transition, there were political, social and ideological, but also journalistic updates in the country, which caused the newspaper Arriba, founded by 'Falange Española' and assimilated as a propaganda organ by Franco's regime during the dictatorship, evolved during the Spanish transition. Due to the incoming ideologies in its newsroom, the newspaper went from supporting the government after Caudillo's death (November, 1975), to criticize it at the end of the period, during the referendum of the Constitution (December, 1978).

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Severe hemolytic anemia and skin reaction in a patient treated with imatinib

Cited by 14 publications

References 4 publications

Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank

Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank

Hematologic toxicities of small molecule tyrosine kinase inhibitors

Arriba durante la Transición española: el abandono de su función propagandística con respecto al Gobierno

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