Severe hepatosplenic schistosomiasis: clinicopathologic study of 102 cases undergoing splenectomy

Li, Yuesheng; Chen, Dongliang; Ross, Allen G.; Burke, Melissa L.; Yu, Xiaoling; Li, Robert S.; Zhou, Jie; McManus, Donald P.

doi:10.1016/j.humpath.2010.05.020

Cited by 24 publications

(28 citation statements)

References 26 publications

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“…In accordance with other studies [54], [55], we found that patients with advanced schistosomiasis japonica were, on average, above 40 years, with lower levels of general, and health-specific, education. We also found a growing trend of advanced schistosomiasis japonica among the young and/or female populations, especially those originating from low-endemic areas.…”

Section: Discussionsupporting

confidence: 92%

Health Access Livelihood Framework Reveals Potential Barriers in the Control of Schistosomiasis in the Dongting Lake Area of Hunan Province, China

et al. 2013

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BackgroundAccess to health care is a major requirement in improving health and fostering socioeconomic development. In the People's Republic of China (P.R. China), considerable changes have occurred in the social, economic, and health systems with a shift from a centrally planned to a socialist market economy. This brought about great benefits and new challenges, particularly for vertical disease control programs, including schistosomiasis. We explored systemic barriers in access to equitable and effective control of schistosomiasis.MethodologyBetween August 2002 and February 2003, 66 interviews with staff from anti-schistosomiasis control stations and six focus group discussions with health personnel were conducted in the Dongting Lake area, Hunan Province. Additionally, 79 patients with advanced schistosomiasis japonica were interviewed. The health access livelihood framework was utilized to examine availability, accessibility, affordability, adequacy, and acceptability of schistosomiasis-related health care.Principal FindingsWe found sufficient availability of infrastructure and human resources at most control stations. Many patients with advanced schistosomiasis resided in non-endemic or moderately endemic areas, however, with poor accessibility to disease-specific knowledge and specialized health services. Moreover, none of the patients interviewed had any form of health insurance, resulting in high out-of-pocket expenditure or unaffordable care. Reports on the adequacy and acceptability of care were mixed.Conclusions/SignificanceThere is a need to strengthen health awareness and schistosomiasis surveillance in post-transmission control settings, as well as to reduce diagnostic and treatment costs. Further studies are needed to gain a multi-layered, in-depth understanding of remaining barriers, so that the ultimate goal of schistosomiasis elimination in P.R. China can be reached.

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Section: Discussionsupporting

confidence: 92%

Health Access Livelihood Framework Reveals Potential Barriers in the Control of Schistosomiasis in the Dongting Lake Area of Hunan Province, China

et al. 2013

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“…Co-infection with S. japonicum and HBV is associated with accelerated deterioration in hepatic function, often referred to as decompensated liver disease [37]. Data from an extensive study in 2007–2008 showed that co-infection with HBV and S. japonicum in 102 patients with hepatosplenomegaly led to more severe fibrosis and inflammatory activity in the liver [32], a feature noted also in an earlier study from this area in the 1990s [38].…”

Section: Pathology and Morbidity Due To Schistosomiasis In The Dongtimentioning

confidence: 86%

“…Clinical manifestations of S. japonicum infection can be divided into three forms: acute, chronic, and advanced hepatic disease [21], [32], [33].…”

Section: Pathology and Morbidity Due To Schistosomiasis In The Dongtimentioning

confidence: 99%

“…Various commercial immunodiagnostic kits based on serum ELISA and the indirect hemagglutination (IHA) test for detection of anti– S. japonicum antibodies have been applied in the Dongting Lake region [32], [40]. Antibody detection is useful in a few specific circumstances, such as when screening for new and re-emerging endemic areas, where the procedure is more sensitive than stool examination.…”

Section: Diagnosismentioning

confidence: 99%

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Schistosomiasis Research in the Dongting Lake Region and Its Impact on Local and National Treatment and Control in China

et al. 2011

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Schistosomiasis is a chronic and debilitating parasitic disease that has often been neglected because it is a disease of poverty, affecting poor rural communities in the developing world. This is not the case in the People's Republic of China (PRC), where the disease, caused by Schistosoma japonicum, has long captured the attention of the Chinese authorities who have, over the past 50–60 years, undertaken remarkably successful control programs that have substantially reduced the schistosomiasis disease burden. The Dongting Lake region in Hunan province is one of the major schistosome-endemic areas in the PRC due to its vast marshland habitats for the Oncomelania snail intermediate hosts of S. japonicum. Along with social, demographic, and other environmental factors, the recent completion and closure of the Three Gorges dam will most likely increase the range of these snail habitats, with the potential for re-emergence of schistosomiasis and increased transmission in Hunan and other schistosome-endemic provinces being a particular concern. In this paper, we review the history and the current status of schistosomiasis control in the Dongting Lake region. We explore the epidemiological factors contributing to S. japonicum transmission there, and summarise some of the key research findings from studies undertaken on schistosomiasis in Hunan province over the past 10 years. The impact of this research on current and future approaches for sustainable integrated control of schistosomiasis in this and other endemic areas in the PRC is emphasised.

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“…6 Ascites, hepatosplenomegaly, hypersplenism, varices, and variceal bleeding may occur as a consequence of portal hypertension. 17,18 …”

Section: Introductionmentioning

confidence: 99%

Prevention and control of schistosomiasis: a current perspective

Inobaya¹,

Olveda²,

Chau³

et al. 2014

RRTM

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Schistosomiasis is a neglected tropical disease that ranks second only to malaria in terms of human suffering in the tropics and subtropics. Five species are known to infect man and there are currently over 240 million people infected worldwide. The cornerstone of control to date has been mass drug administration with 40 mg/kg of praziquantel but there are problems with this approach. Human and bovine vaccines are in various stages of development. Integrated control, targeting the life cycle, is the only approach that will lead to sustainability and future elimination.

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Severe hepatosplenic schistosomiasis: clinicopathologic study of 102 cases undergoing splenectomy

Cited by 24 publications

References 26 publications

Health Access Livelihood Framework Reveals Potential Barriers in the Control of Schistosomiasis in the Dongting Lake Area of Hunan Province, China

Health Access Livelihood Framework Reveals Potential Barriers in the Control of Schistosomiasis in the Dongting Lake Area of Hunan Province, China

Schistosomiasis Research in the Dongting Lake Region and Its Impact on Local and National Treatment and Control in China

Prevention and control of schistosomiasis: a current perspective

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