Severe hindlimb ischemia causes periosteal proliferation in the rat tibia

Skjeldal, Sigmund; Svindland, Aud; Hvaal, Kjetil; Kase, Trygve; Reikerås, Olav; Nordsletten, Lars

doi:10.3109/17453679708999033

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Periosteal hyperplasia without evidence of neoplasia extended further than intramedullary neoplasia in 4 of 10 dogs and did not extend as far as intramedullary neoplasia in 5 of 10 dogs. This discrepancy between tumor length and length of periosteal reaction is not surprising as there are several causes of periosteal bone proliferation other that neoplastic infiltration, including ischemia …”

Section: Discussionmentioning

confidence: 99%

Accuracy of Computed Tomography in Determining Lesion Size in Canine Appendicular Osteosarcoma

Karnik

Samii

Weisbrode

et al. 2012

Vet Radiology Ultrasound

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Multidetector contrast enhanced computed tomography with acquisition of 0.625-mm thick transverse images was used to measure the extent of appendicular osteosarcoma in 10 dogs. The measured length of tumor based on CT was compared to the true length of tumor using histopathology. There was a statistically significant association with good correlation between the true length of osteosarcoma compared to the length of intramedullary/endosteal abnormalities on CT with a mean overestimation of 1.8% (SD = 15%). There was not a statistically significant association between the true tumor length and the length of periosteal proliferation on CT with a mean overestimation of 9.7% (SD = 30.3%). There was a statistically significant association, but with poor correlation, between the true tumor length compared to the length of abnormal contrast enhancement with a mean overestimation of 9.6% (SD = 34.8%). The extent of intramedullary/endosteal CT abnormalities assessed from submillimeter transverse images may be of value in assessing patient candidacy and surgical margins for limb-sparing surgery

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Section: Discussionmentioning

confidence: 99%