Severe Hypermagnesemia with Normal Renal Function Can Improve with Symptomatic Treatment

Ishida, Yoshiaki; Tabuchi, Akihiko

doi:10.1155/2020/2918249

Cited by 5 publications

(7 citation statements)

References 14 publications

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“…Other less common causes of hypermagnesemia occur when patients are administered large doses of magnesium, either intravenous or orally, and increased absorption of magnesium from the gastrointestinal tract in patients with constipation, colitis, gastritis, and gastric ulcer disease. 10 , 11 …”

Section: Discussionmentioning

confidence: 99%

Hypermagnesemia Complicated by Acute Flaccid Paralysis, Case Report

Mulisa,

Bekele,

Mulate

et al. 2024

IMCRJ

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Hypermagnesemia is a rare electrolyte abnormality observed in the clinical setting. Patients with this condition can present with a variety of symptoms, depending on the level of serum magnesium. Hypermagnesemia is rarely complicated by weakness of the extremities. We report the case of 32 years old female patient who presented with bilateral upper- and lower-extremity weakness due to hypermagnesemia. Following correction of the serum magnesium level, extremity weakness subsided, and the patient was discharged with improvement. Here, we discuss the delay in the diagnosis and management of this type of clinical presentation.

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Section: Discussionmentioning

confidence: 99%

Hypermagnesemia Complicated by Acute Flaccid Paralysis, Case Report

Mulisa,

Bekele,

Mulate

et al. 2024

IMCRJ

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“…When magnesium levels increase above 5 mg/dL, symptoms such as nausea, vomiting, and dizziness may occur. When magnesium levels exceed 9 mg/dL, deep tendon reflexes diminish, and manifestations may progress to bradycardia, hypotension, hypoventilation, mental changes, respiratory arrest, and even cardiac arrest 14 15) . In the first case, although the other vital signs were stable, there was a change in consciousness.…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of hypermagnesemia depends on kidney dysfunction and symptom severity. It includes discontinuing causative medications, promoting magnesium excretion through hydration and loop diuretics, or dialysis in severe cases 14) . Calcium administration is necessary to address symptoms, such as hypotension, respiratory depression, and arrhythmias.…”

Section: Discussionmentioning

confidence: 99%

Fatal Hypermagnesemia in Patients Taking Magnesium Hydroxide

Jou,

Kim,

Choi

et al. 2023

Electrolyte Blood Press

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Hypermagnesemia is a rare but potentially fatal electrolyte disorder often overlooked because of its unfamiliarity. Magnesium is regulated through a balance of bone, intestinal absorption, and renal excretion. Hypermagnesemia typically arises from excessive magnesium intake or reduced renal excretion; however, it also occurs in patients with normal kidney function. Herein, we report two cases of hypermagnesemia in patients taking magnesium hydroxide for constipation. The first case involved an 82-year-old woman with end-stage renal disease who developed metabolic encephalopathy due to hypermagnesemia, after taking 3,000 mg of magnesium hydroxide daily for constipation. Her magnesium level was 9.9 mg/dL. Her treatment involved discontinuing magnesium hydroxide and continuing hemodialysis, which led to her recovery. In the second case, a 50-year-old woman with a history of cerebral hemorrhage and mental retardation developed hypermagnesemia despite having normal renal function. She was also taking magnesium hydroxide for constipation, and her magnesium level was 11.0 mg/dL. She experienced cardiac arrest while preparing for continuous renal replacement therapy (CRRT). After achieving return of spontaneous circulation, CRRT was initiated, and her magnesium level showed a decreasing trend. However, vital signs and lactate levels did not recover, leading to death. These cases highlight the importance of prompt diagnosis and intervention for hypermagnesemia and the need to regularly monitor magnesium levels in individuals receiving magnesium-containing preparations, especially those with impaired kidney function.

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“… 2 Extreme hypomagnesemia was defined as a serum Mg concentration of <0.75 mg/dL and extreme hypermagnesemia as >13.50 mg/dL. 39 , 40 …”

Section: Methodsmentioning

confidence: 99%

Clinical Factors Associated with Serum Magnesium Concentration in Patients Undergoing Peritoneal Dialysis: A Single-Center Observational Study

Kaneko¹,

Ookawara²,

Morishita³

2022

IJNRD

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Purpose Magnesium (Mg) is an essential element that is associated with various physiological functions, such as maintenance of blood pressure, muscle contraction, and nerve function. In patients undergoing hemodialysis, hypomagnesemia is associated with cardiovascular and all-cause mortality. However, in patients undergoing peritoneal dialysis (PD), clinical factors associated with Mg have not been fully investigated. Patients and Methods Clinical factors including anthropometric data, comorbidities, laboratory data, medications, and dialysis methods were collected from the medical records of patients undergoing PD. The associations of these factors with the serum Mg concentration were investigated by univariate and multivariate analyses. Results Sixty patients undergoing PD were investigated. The univariate analysis showed that the serum Mg concentration was significantly associated with treatment by hybrid PD (daily PD + once-weekly hemodialysis) (β = 0.264, P = 0.04), administration of phosphate binders (β = 0.294, P = 0.02), the serum C-reactive protein concentration (β = −0.318, P = 0.01), the serum potassium (K) concentration (β = 0.451, P < 0.01), and the serum intact parathormone concentration (β = −0.333, P = 0.01). The multivariate analysis using these factors showed an independent association between the serum Mg and K concentrations (β = 0.333, P = 0.01). Conclusion The serum Mg concentration was independently associated with the serum K concentration in patients undergoing PD.

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Severe Hypermagnesemia with Normal Renal Function Can Improve with Symptomatic Treatment

Cited by 5 publications

References 14 publications

Hypermagnesemia Complicated by Acute Flaccid Paralysis, Case Report

Hypermagnesemia Complicated by Acute Flaccid Paralysis, Case Report

Fatal Hypermagnesemia in Patients Taking Magnesium Hydroxide

Clinical Factors Associated with Serum Magnesium Concentration in Patients Undergoing Peritoneal Dialysis: A Single-Center Observational Study

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