Severe Hypertriglyceridemia in Diabetic Ketoacidosis Accompanied by Acute Pancreatitis: Case Report

Abstract

We report a case of diabetic ketoacidosis (DKA) and hypertriglyceridemia (severely elevated to 15,240 mg/dL) complicated by acute pancreatitis, which was treated successfully with insulin therapy and conservative management. A 20-yr-old woman with a history of type 1 diabetes came to the emergency department 7 months after discontinuing insulin therapy. DKA, severe hypertriglyceridemia and acute pancreatitis were diagnosed, with DKA suspected of contributing to the development of the other conditions. In Korea, two cases of DKA-induced hypertriglyceridemia and 13 cases of hypertriglyceridemia-induced acute pancreatitis have been previously reported separately.

ApoE isoform leading to hypertriglyceridemia in new onset type 1 diabetes

“…A literature search revealed that hypertriglyceridemia associated with hyponatremia and DKA has been described in at least one other case report. In that previous report, the etiology of this significant degree of hyponatremia was unknown and the hyponatremia corrected with the administration of IV 3% NaCl solution 20. In our patient, close observation and a change in the sodium concentration in the IVF’s (1/2NS to NS) resulted in resolution of the perceived hyponatremia.…”

Diabetic ketoacidosis with acute kidney injury in prepubertal children: a report on two cases

“…32 Once dyslipidemia is diagnosed in children with type 1 diabetes, the dyslipidemia should be treated per lipid guidelines for adults with diabetes. 22 Blood pressure was elevated in our two patients.…”

Diabetic Ketoacidosis With Acute Necrotizing Pancreatitis as First Presentation in Latent Autoimmune Diabetes in Adult

“…It is reported that 24.7-79.0% of patients with DKA have non-specific elevation of amylase or lipase. For this reason, DKA is reported to mask a co-existing AP in 10-15% of cases [11]. Timely diagnosis of AP in DKA is critical as it would change the course of treatment.…”