Severe hypoxia and hypothermia following barbiturate poisoning

Hantson, Philippe; Ziade, Dany; Evenepoel, M.; Mahieu, Paul

doi:10.1007/bf02044134

Cited by 5 publications

(6 citation statements)

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“…Even though the implications and mechanisms of anapyrexia have been studied mostly in small animals and neonates, which have a higher surface/ volume and metabolic rates compared with larger species, it should be emphasized that anapyrexia reportedly also occurs in adult humans. In particular, in a 50-year-old man intoxicated with barbiturate, PaO 2 was approximately 28 mmHg and T c as low as 28.4 C [16]. Interestingly, organ protection and fast recovery was observed in this patient [16].…”

Section: Discussionmentioning

confidence: 89%

“…In particular, in a 50-year-old man intoxicated with barbiturate, PaO 2 was approximately 28 mmHg and T c as low as 28.4 C [16]. Interestingly, organ protection and fast recovery was observed in this patient [16].…”

Section: Discussionmentioning

confidence: 89%

“…The brain temperature of rats decreases spontaneously from 36 to 30-31 C during cerebral ischaemia [7], hence preventing cell damage, whereas animals in which the brain temperature is maintained by heat lamps show histopathological changes in the microscopic anatomy of the hippocampus following ischaemia. Moreover, Hantson et al has reported organ protection and fast recovery in a 50-year-old man intoxicated with barbiturate, and with an arterial O 2 partial pressure (PaO 2 ) as low as 28 mmHg and T c as low as 28.4 C [16]. Forced hypothermia is also sometimes used in surgical procedures, particularly for heart and brain surgery [4,15,30], and as a means of reducing the pathological damage resulting from traumatic brain injury, ischaemia and other insults in various organs [15].…”

Section: Introductionmentioning

confidence: 98%

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Is lactate a mediator of hypoxia-induced anapyrexia?

Bícego

Steiner

Gargaglioni

et al. 2002

Pfl�gers Archiv European Journal of Physiology

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Hypoxia causes a regulated decrease in body core temperature ( T(c)), termed anapyrexia, which seems to be a very effective way of preventing hypoxia-associated cell damage. Since during several pathological states the supply of O(2) is a limiting factor, the clinical importance of anapyrexia is evident. However, the mechanisms involved in this response remain unclear. We tested the hypothesis that lactate, a classic companion of hypoxia, is a mediator of hypoxia-induced anapyrexia, using the inhibitor of acid lactic production dichloroacetate (DCA). Each of 28 rats was placed in a chamber ventilated with humidified air at an ambient temperature of 24-26 degrees C. After a control period of 30 min the animals were given saline or 100 mg/kg DCA i.p. Then, 30 min later, the chamber was flushed with a 7% O(2) gas mixture for 2 h. At the end of the experiment, the animals were decapitated and blood samples collected for measurements of plasma lactate. T(c) was measured by biotelemetry. DCA did not affect the T(c) or basal lactate levels of normoxic rats. Hypoxia elicited a significant decrease in T(c) and an increase in plasma lactate levels. Although DCA decreased plasma lactate levels during hypoxia, it caused no change in the course of hypoxia-induced anapyrexia. Correspondingly, no correlation was found between the drop in T(c) and the rise in plasma lactate during hypoxic conditions. These results do not support the hypothesis that lactate is a mediator of hypoxia-induced anapyrexia in rats.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Is lactate a mediator of hypoxia-induced anapyrexia?

Bícego

Steiner

Gargaglioni

et al. 2002

Pfl�gers Archiv European Journal of Physiology

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show abstract

“…Numerous case reports have described hypothermia with barbiturates, usually in the setting of overdose. 2,[5][6][7][8][9] Lee and Ames first documented an incidence of hypothermia in *50% of barbiturate overdoses in a 1965 case series that was mostly associated with short-acting barbiturates. 5 In 1966, another case reported noted severe hypothermia of 23 C with an overdose of 50 capsules of sodium amylobarbitone.…”

Section: Discussionmentioning

confidence: 99%

“…A recent case report noted a barbiturate overdose caused hypothermia. 2 In addition, topiramate has been associated with 22 case reports of hypothermia based upon a case series reviewing the US Food and Drug Administration's (FDA) Adverse Events Reporting System (AERS) database from 1999 through 2007. 3 The topiramate hypothermia cases were not usually a result of monotherapy but occurred with a concomitant antiepileptic.…”

Section: Introductionmentioning

confidence: 99%