Severe <i>Plasmodium falciparum</i> Malaria Treated With Investigational Artesunate in the United States

Shah, Punit J.; Koshy, Janice; Everett, Nichelle; Attia, Engie

doi:10.1177/0897190018782367

Cited by 7 publications

(7 citation statements)

References 7 publications

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“…Treatment of CM, the most dangerous symptom, is liquid quinine (Nishanth and Schlüter, 2019) and supportive measures (Idro et al, 2010). Recently, artesunate has also been used for treating CM (Shah et al, 2020). Unfortunately, P. falciparum, the most dangerous species, of Plasmodium has become resistant to all anti-plasmodial drugs including ACTs (Tiwari and Chaudhary, 2020).…”

Section: Discussionmentioning

confidence: 99%

Treatment of Experimental Cerebral Malaria by Slow Release of Artemisone From Injectable Pasty Formulation

et al. 2020

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Malaria caused by Plasmodium falciparum causes numerous cases of morbidity with about 400,000 deaths yearly owing, mainly, to inflammation leading to cerebral malaria (CM). CM conventionally is treated by repetitive administration of anti-plasmodial drugs and supportive non-specific drugs, for about a week. A mouse model of CM caused by Plasmodium berghei ANKA, in which brain and systemic clinical pathologies occur followed by sudden death within about a week, was used to study the effect of artemisone, a relatively new artemisinin, within an injectable pasty polymer formulated for its controlled release. The parasites were exposed to the drug over several days at a non-toxic concentrations for the mice but high enough to affect the parasites. Artemisone was also tested in cultures of bacteria, cancer cells and P. falciparum to evaluate the specificity and suitability of these cells for examining the release of artemisone from its carrier. Cultures of P. falciparum were the most suitable. Artemisone released from subcutaneous injected poly(sebacic acid-ricinoleic acid) (PSARA) pasty polymer, reduced parasitemias in infected mice, prolonged survival and prevented death in most of the infected mice. Successful prophylactic treatment before infection proved that there was a slow release of the drug for about a week, which contrasts with the three hour half-life that occurs after injection of just the drug. Treatment with artemisone within the polymer, even at a late stage of the disease, helped to prevent or, at least, delay accompanying severe symptoms. In some cases, treatment prevented death of CM and the mice died later of anemia. Postponing the severe clinical symptoms is also beneficial in cases of human malaria, giving more time for an appropriate diagnosis and treatment before severe symptoms appear. The method presented here may also be useful for combination therapy of anti-plasmodial and immunomodulatory drugs.

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Section: Discussionmentioning

confidence: 99%

Treatment of Experimental Cerebral Malaria by Slow Release of Artemisone From Injectable Pasty Formulation

et al. 2020

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“…Because of the enormous percentage of individuals registered per year, vector-borne diseases (VBD) are a threat to developing countries. Overwhelming of healthcare services in poor-resource countries could result in outbreaks of VBDs like dengue and malaria [12,13]. Dengue fever is the largest human arboreal disease spread worldwide, causing more sickness and death than all of the other aerobic diseases [14] by A. aegypti and A. albopictus mosquito.…”

Section: Introductionmentioning

confidence: 99%

Awareness and perception of malaria and dengue at school and college level in the district of Multan

Essa

Taj²,

Khan³

et al. 2022

PLoS ONE

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The purpose of this study is to examine the awareness and perception of malaria and dengue fever in Multan Punjab, Pakistan while taking into account the important role of government policies and other variables. The goal of this study is to examine the awareness of students in Multan, Pakistan on malaria and dengue. This study is based on a quantitative approach of secondary evidence from scientific journals and questionnaire surveys. It is also based on observational evidence gathered in Multan Punjab Pakistan, in a field study. The survey with school children, teachers and healthcare professionals were both formal and semi-structuralize. Studies have found that malaria and dengue mainly affect children’s schooling through their absence, but can also induce brain loss and cognitive disability. In questionnaires, students were seen to have different understanding of the illness, but also to be able to serve as agents of health reform only through teachers. A sample size of 500 respondents has been selected from different colleges of district Multan Punjab, Pakistan. Correlation technique is used for the data analysis. According to our results it is concluded that the students at college level are aware of malaria and dengue diseases, but they are not capable of engaging and serving as agents for health reform. On the basis of results it is recommended that students must teach about epidemics diseases regarding how to handle these diseases.

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“…Using artemisinin in combination with other drugs for treatment of malaria at an early stage, preventive treatment for pregnant women, and residual spraying or mosquito nets have proven to be effective tools in malaria control [8,49] . New tools developed are production of new drugs with better efficiency, vaccines for treatment and prevention, new diagnostic tests, innovative materials that can be treated with insecticide, better systems for delivering and evaluating malaria control [11] .…”

Section: Other Latest Developments In Malaria Controlmentioning

confidence: 99%

Evolutionary outlook on the impending endgame of malaria

Rathod¹,

Hanagodu²,

Patil³

2023

Int. J. Mosq. Res.

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Malaria is a highly debilitating vector-borne parasitic infection which has been known to be mortal and morbid to human beings for centuries now. As of today, the success rate of effective control strategies is less; however there have been several riveting developments. These include: 1. A global incidence of decrease in malaria cases; 2. The development of several non-malaria transmissible transgenic mosquitoes and 3. The launch of the vaccine has been a game changer as it is now being given to children with the success rate being high. In this review, we discuss if the current control strategies in place and the launch of the vaccine and its speculated success in children has become/been a game changer. Our take on the coevolution of parasites and vector can be the answer to the questions above. We highlight that parasites and vectors have evolved together for millions of years now, and to break this liaison will not be as easy.

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Severe Plasmodium falciparum Malaria Treated With Investigational Artesunate in the United States

Abstract: A patient with severe falciparum malaria was successfully treated with investigational artesunate procured from the CDC.

Cited by 7 publications

References 7 publications

Treatment of Experimental Cerebral Malaria by Slow Release of Artemisone From Injectable Pasty Formulation

Treatment of Experimental Cerebral Malaria by Slow Release of Artemisone From Injectable Pasty Formulation

Awareness and perception of malaria and dengue at school and college level in the district of Multan

Evolutionary outlook on the impending endgame of malaria

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