Severe Infantile Bullous Pemphigoid Treated with Dapsone after Bridging with Systemic Glucocorticoid

Abstract

We present a case of severe and treatment-refractory bullous pemphigoid in a 3-month-old child. After topical and systemic corticoid treatment proved inefficient, dapsone 0.75 mg/kg was added initially without success. Disease control was reached with dapsone 1.5 mg/kg in addition to both topical and systemic glucocorticoid treatment, leaving the child with several side effects of the glucocorticoid treatment.

An Unusual TEN-Like Presentation of Juvenile Bullous Pemphigoid: A Diagnostic Challenge

“…Dapsone was well-tolerated by the patient, so prednisolone could be tapered successfully within 3 months. This result corresponds with a recent report of a refractory case of childhood BP that was successfully controlled by dapsone and systemic steroids [ 10 ].…”

Recalcitrant infantile bullous pemphigoid successfully treated with cyclosporine

“… 1 Recalcitrant cases of IBP were described to benefit from dapsone and IVIG, and the use of rituximab was also reported. 5 , 6 , 8 …”

“… 1 , 2 , 3 , 4 The treatment of IBP primarily relies on corticosteroids, but dapsone and intravenous immunoglobulins (IVIG) are also used in refractory cases. 5 , 6 In the following report, we present the first case of IBP treated successfully with cyclosporine as a monotherapy.…”

Two infants with blistering rashes originating on acral sites as a presenting sign of infantile bullous pemphigoid

“…Most infantile BP cases respond quickly to systemic corticosteroids, but dapsone is often given with systemic corticosteroids in refractory cases. 1,3,8 intravenous immunoglobulin may also be considered in infantile BP treatment, especially in recalcitrant disease. 4,9,10 Although infantile BP is considered a rare disease, its incidence has been growing.…”