Severe Infection Due to Actinomyces bernardiae: Case Report

Ieven, M.; Verhoeven, Jo; Gentens, P.; Goossens, H.

doi:10.1093/clinids/22.1.157

Cited by 33 publications

(21 citation statements)

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“…bernardiae has been described as a pathogen in urinary tract infections (Ieven et al, 1996;Lepargnear et al, 1998), joint infections (Adderson et al, 1998;Bemer et al, 2009;Lo ez et al, 2009), skin and soft-tissue infections (Weitzel et al, 2011;Otto et al, 2013), necrotizing fasciitis (Clarke et al, 2010) and a case of eye infection (Funke et al, 1995). Six strains of T. bernardiae have been cultured from blood specimens, but no deaths due to T. bernardiae have been reported.…”

Section: Introductionmentioning

confidence: 99%

A case of diabetic foot ulcers complicated by severe infection and sepsis with Trueperella bernardiae

et al. 2015

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Introduction: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) allows us to identify bacteria directly from positive blood cultures with detailed taxonomy naming of the bacterial strains. Knowing the name of the infective bacteria makes it possible to adjust the antibiotic therapy early on. However, it also gives rise to detection of a number of unusual pathogens, which raises new questions on the pathogenicity and medical importance of a number of rarely isolated bacteria such as Trueperella bernardiae.Case presentation: We describe a case of diabetic foot ulcers in a 45-year-old male, which led to below-the-knee amputation due to widespread infection and sepsis with T. bernardiae and coinfection with Peptoniphilus lacrimalis. The patient was treated initially with surgical debridement in combination with piperacillin/tazobactam and thereafter with amoxicillin for a total period of 1 month.Conclusion: Based on this case, as well as previous case reports in the literature, we conclude that T. bernardiae is a rarely isolated low-pathogenic bacterium in patients with severe comorbidities. Often co-infection with other low-pathogenic bacteria is observed. T. bernardiae is susceptible to and readily treated with b-lactam antibiotics.

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Section: Introductionmentioning

confidence: 99%

A case of diabetic foot ulcers complicated by severe infection and sepsis with Trueperella bernardiae

et al. 2015

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“…Since some coagulase-negative species can be distinguished only by a limited number of stable biochemical tests, the precise assignment of a staphylococcal strain to a species is difficult to obtain. What is more, atypical characteristics such as phosphatasenegative reactions in certain Staphylococcus epidermidis strains often result in their misidentification as Staphylococcus hominis (Ieven et al, 1995). Fatty acid compositions of coagulase-negative staphylococcal species showing quantitative but not qualitative differences in certain acids are applied for their identification (Kotilainen et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Rapid identification of Staphylococcus epidermidis.

Wieser¹,

Busse²

2000

International Journal of Systematic and Evolutionary Microbiology

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During the collection of airborne bacteria in a museum in England some bacterial strains were isolated which due to their fatty acid profiles were clearly identified as members of the genus Staphylococcus. As fatty acid compositions of coagulase-negative staphylococci are very similar, differing only in quantities but not in qualities, further identification at the species level without a fatty acid database was not achieved. Investigation of the isolates using the Staph ID 32 API system resulted in an identification of the isolates as

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“…bernardiae is a gram-positive bacillus that forms part of the normal microbiota of human skin and the oropharynx. Few cases of infection due to this microorganism in pure culture have been reported until now (4)(5)(6)(7)(8)(9)(10)(11)(12), and 5 additional cases have been reported as causing mixed infections ( Table 1). The true incidence of infections with this bacterium is unknown because when isolated in clinical samples, these coryneform bacteria are not identified.…”

Section: Infections Due To Trueperella Bernardiaementioning

confidence: 99%

“…Some studies have shown that T. bernardiae is susceptible to all antimicrobial drugs tested, except for ciprofloxacin (4,15). However, other studies show resistance to clindamycin and erythromycin (9), norfloxacin and fosfomycin (13), metronidazole (6), pefloxacin (5), and penicillin G (7).…”

Section: Infections Due To Trueperella Bernardiaementioning

confidence: 99%