Severe Inflammation in the Background Liver Cirrhosis Correlates with the Development of Poorly Differentiated HCC in HCV-Associated Liver Cirrhosis

Abstract

Objective Whether severe inflammation in the background liver cirrhosis might correlate with the development of poorly differentiated human hepatocellular carcinoma (HCC) was studied in hepatitis C virus (HCV)-associated liver cirrhosis. Methods Out of 214 HCC patients who underwent curative hepatic resection, 148 patients were HCVassociated liver cirrhosis (LC) patients. Out of these 148, 31 patients with small solitary HCC nodule (diameter ! 3 cm) were included in this study. Inflammation in the background LC was evaluated by modified histology activity index (HAI). To evaluate the inflammation, piece meal necrosis, intra lobular cellular degeneration and focal necrosis, portal cellular inflammation (each 0-4) were estimated. In each case, the average HAI was calculated. The grade of malignancy of HCC was determined by World Health Organization (WHO) classification. Results The average HAI score in the cirrhotic portion in 17 patients with poorly differentiated HCC (5.21±1.15, mean ± standard deviation (SD)) was significantly larger than that in 14 patients without poorly differentiated HCC (4.05±0.83, p<0.005). The occurrence rate of HCC containing poorly differentiated HCC component in the patients whose HAI was more than 5.0 was 80.0% (12 out of 15), and was significantly higher compared with those in patients whose HAI was less than 5.0 (5 out of 16, 31.3%, p<0.025). In univariate and multivariate analyses for contribution to poorly differentiated HCC development, HAI was the only significant contributor (p=0.011, p=0.012 respectively). Conclusion It is suggested that severe inflammation in the background cirrhosis accelerates the promotion in the HCC development from HCV-associated LC.

Serum Endotoxin Level in Cirrhotic Patients with Hepatic Encephalopathy

“…Benha Journal Of Applied Sciences, Vol. ( 6) Issue ( 6) Part (2) (2021( known to increase permeability of the blood-brain barrier and to act on the brain microglia through endothelial cell receptors with the succeeding production of nitric oxide (NO) and prostanoid, which may ultimately enhance the astrocyte swelling in HE [14] Tarao et al [15] reported that child pugh score is decreased with increased endotoxin level leading to death occurred within 6 months in 47.8% of the patients with a positive endotoxin test, whereas only 16.7% of those with a negative test died in the same period.…”