Severe inflammatory reaction following corneal collagen cross-linking in a patient with glucose-6-phosphate dehydrogenase deficiency

Bostan, Cristina; Robert, Marie-Claude

doi:10.1016/j.jcjo.2018.12.006

Cited by 2 publications

(1 citation statement)

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“…Glucose-6-P allows maintenance and reduces oxygen radicals produced by cellular metabolism, and G6PD deficiency can cause neonatal jaundice and acute haemolytic anemia triggered by increased oxidative stress. where, glucose 6 phosphate promote alpha heme synthesis and glycogen synthase productions that allows anti-inflammation processes and promote PD1 re-activities (that stop the Adoptive binding of PD-1 with PD-L1 then will be separated ), and then will reactivate T-cells and NK cells [41].…”

Section: Socs Suppressor Of Cytokine Signalingmentioning

confidence: 99%

PD-1 /PD-L1 Adoptive Checkpoint Biosynthesis Separately Are Regulated By Gamma Common Which Regulate PD-1, Globin, and IFN-Gamma

Tantawi¹,

Egypt²

2021

Jap J Clin & Med Res

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PD-1 /PD-L1 is adoptive checkpoint mechanism, where PD-1 is an adopting its PD-L1 ligand activities by presence of specific helical kinase proteins in its compositions: _gamma common chains,_LNK” lymphocyte adaptor protein, _or SH2B adaptor _protein “tyrosine kinases, and _”SOCS” suppressor of cytokine signaling, that specified for controlling PD-1 and PD-L1 bindings activity through temporary resting the PD-L1 and consequently T-cells activities then transform incoming signals to exogenous processes in favor the of proper immune functions, But the permanent inhibition of PD-1 /PD-L1 binding is due to breaking down or inhibition in one or more of the adaptors helical proteins (lymphocyte adaptor protein, or SH2B) with the presence of SOCS” suppressor of cytokine signaling that will increase stability of binding without adopting and without activities, but cells survival can still exist through presence of tyrosine kinases , interferon stimulate kinases ,and gamma common.

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Section: Socs Suppressor Of Cytokine Signalingmentioning

confidence: 99%