Severe invasive Panton-Valentine Leucocidin positive Staphylococcus aureus infections in children in London, UK

Cunnington, Aubrey J.; Brick, Thomas; Cooper, Marie; Danin, J.C.; Hunt, David M.; Jeanes, Annmarie; Kearns, Angela; Nolan, Marianne; Lyall, Hermione

doi:10.1016/j.jinf.2009.05.003

Cited by 32 publications

(45 citation statements)

References 22 publications

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“…Recent in vitro data, however, demonstrate that PVL-knockout strains of S. aureus are equally as virulent in a mouse model of osteomyelitis [13]. Regardless of the specific role of PVL, CA-MRSA osteomyelitis is highly associated with many complications such as adjacent pyomyositis, progression to chronic osteomyelitis, deep venous thrombosis, and a high rate of multifocal infection [14], and has greatly altered the landscape of pediatric osteomyelitis since its epidemic rise [8,15].…”

Section: The Changing Epidemiology Of Pediatric Osteomyelitismentioning

confidence: 99%

Advances in the Diagnosis and Management of Pediatric Osteomyelitis

Thomsen

Creech

2011

Curr Infect Dis Rep

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Acute hematogenous osteomyelitis is a common disease that affects previously healthy children of all age groups. Despite its importance, there are limited data in the current literature to guide many aspects of the diagnosis and therapy of this infection. Over the last decade, our understanding of the etiology of this infection has changed, with increased recognition of Kingella kingae and the dramatic increase in community-associated Methicillin-resistant Staphylococcus aureus (CA-MRSA) infections. There is a need for the optimization of diagnostic strategies, such as MRI and serum inflammatory markers. Several recent studies have examined treatment strategies, including a rapid transition to oral antimicrobial therapy and a shortened overall course of therapy. Many new therapeutic options are on the horizon that will likely impact the management of this and other childhood bacterial infections. This review summarizes recent investigations into the optimal diagnosis and management of acute hematogenous osteomyelitis in children.

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Section: The Changing Epidemiology Of Pediatric Osteomyelitismentioning

confidence: 99%

Advances in the Diagnosis and Management of Pediatric Osteomyelitis

Thomsen

Creech

2011

Curr Infect Dis Rep

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“…Currently, though most research is focused on PVL-positive MRSA (PVL-MRSA), a rising incidence of PVL-positive, methicillin-sensitive S. aureus (PVL-MSSA) infections reported recently is the main contributing factor in the increased incidence of PVL-positive strains in some locales, with approximately 60% of total PVL-positive S. aureus isolates in England in the past 5 years found to be susceptible to methicillin (6,16,29). With clinical and epidemiological characteristics similar to those of CA-MRSA (9,25), PVL-MSSA may represent a hitherto-unrecognized, overlooked emerging public health threat. Several studies have recently attempted to address this information imbalance (7,21,27,29); however, only two of these reported on PVL gene polymorphisms and their implications (7,29).…”

mentioning

confidence: 99%

Molecular Characterization and Panton-Valentine Leucocidin Typing of Community-Acquired Methicillin-Sensitive Staphylococcus aureus Clinical Isolates

Otokunefor

Sloan

Kearns³

et al. 2012

J Clin Microbiol

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Limited comprehensive molecular typing data exist currently for Panton-Valentine leucocidin (PVL)-positive, methicillin-sensitive Staphylococcus aureus (PVL-MSSA) clinical isolates. Characterization of PVL-MSSA isolates by multilocus sequence typing (MLST) and spa typing in this study showed a genetic similarity to PVL-positive, methicillin-resistant S. aureus (PVL-MRSA) strains, although three novel spa types and a novel MLST (ST1518) were detected. Furthermore, the detection of PVL phages and haplotypes in PVL-MSSA identical to those previously found in PVL-MRSA isolates highlights the role these strains may play as precursors of emerging lineages of clinical significance.

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“…Number with long-term morbidity Number of fatalities Series 1 9 14 45 (10-90) 2 (0-5) 12 0 Series 2 6 11 51 (14-255) 5 (1-11) 5 1 Case report 19 1 50 3 0 0 Reported case 1 30 4 1 0 versus daptomycin in adults with osteoarticular infections secondary to staphylococcal infection, suggested daptomycin may be considered an alternative to standard therapy. 14 Published use of daptomycin in paediatric infections are also limited and focus mainly on invasive staphylococcal disease of soft tissues.…”

Section: Median Surgical Proceduresmentioning

confidence: 99%

“…6 The condition may start with relatively nonspecific symptoms and include skin lesions 3 and deep abscesses 7 but can include necrotizing pneumonia 3 and complicated musculoskeletal infection. 8,9 Sepsis related multi-organ failure and/or necrotising pneumonia account for the high fatality rates observed 3 and the requirement of intensive care facilities.…”

Section: Introductionmentioning

confidence: 99%

“…Greater severity of infection is seen when compared with a PVL negative infection. 6,10 Daptomycin binds to bacterial membranes in a calciumdependent manner, causing subsequent potassium efflux. This leads to arrest of several intracellular processes, including Deoxyribonucleic acid and Ribonucleic acid production and protein synthesis, thereby hampering PVL production.…”

Section: Introductionmentioning

confidence: 99%

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Successful use of daptomycin in Panton-Valentine leucocidin positive Staphylococcus aureus paediatric osteomyelitis

Erturan

Holme

Smith

et al. 2012

International Journal of Surgery Case Reports

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Repercussions of osteomyelitis, in particular those caused by PVL S. aureus, and evolving resistance patterns internationally, highlight the need for further evaluation of daptomycin in the paediatric arena. The response seen with the addition of Daptomycin in this case suggests possible reduction in hospital stay and number of surgical procedures when compared to other published series using conventional antibiotic regimens.

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Severe invasive Panton-Valentine Leucocidin positive Staphylococcus aureus infections in children in London, UK

Cited by 32 publications

References 22 publications

Advances in the Diagnosis and Management of Pediatric Osteomyelitis

Advances in the Diagnosis and Management of Pediatric Osteomyelitis

Molecular Characterization and Panton-Valentine Leucocidin Typing of Community-Acquired Methicillin-Sensitive Staphylococcus aureus Clinical Isolates

Successful use of daptomycin in Panton-Valentine leucocidin positive Staphylococcus aureus paediatric osteomyelitis

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