Severe Klebsiella infection as a cause of mortality in neonates in Harare, Zimbabwe

Kj, Nathoo; Pr, Mason; Gwanzura, Lovemore; H, Kowo; Mubaiwa, L

doi:10.1097/00006454-199310000-00009

Cited by 20 publications

(6 citation statements)

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“…These are organisms that have previously been shown to cause neonatal sepsis in Kenya and other developing countries (3,19,22,(28)(29)(30). Nathoo and co-workers in Zimbabwe found klebsiella sepsis as the leading cause of mortality especially in LBW and premature infants (31). Only one case of lancefield group B-Beta haemolytic streptococci was found.…”

Section: Discussionmentioning

confidence: 98%

Morbidity and mortality of low birth weight infants in the New Born Unit of Kenyatta National Hospital, Nairobi

Simiyu

2004

E Af Med Jrnl

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Background: Morbidity and mortality of low birth weight (LBW) infants at Kenyatta National Hospital (KNH) has previously been found to be high. Other centres have shown that even with lack of neonatal intensive care facilities, selective interventions can be implemented that improve neonatal survival rates. It is important to identify those factors at KNH that when selectively modified, will improve the quality of care hence survival rates. Objective: To quantify the morbidity and mortality of LBW infants in KNH. To audit the quality of care and identify factors that can be selectively modified to improve the quality of care and improve the currently low survival rates.

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Section: Discussionmentioning

confidence: 98%

Morbidity and mortality of low birth weight infants in the New Born Unit of Kenyatta National Hospital, Nairobi

Simiyu

2004

E Af Med Jrnl

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“…[4][5][6][7][8][9][10][11][12][13][14][15][16][17] However, many of these studies were hospital-based in large urban centers, with a high likelihood for inclusion of nosocomial infections and reflecting an urban population rather than the rural environment where the majority of neonatal deaths occur. Although group B Streptococcus has been a common cause of neonatal sepsis in industrialized countries, 18 its role in developing countries is less certain.…”

Section: Introductionmentioning

confidence: 99%

Serious community-acquired neonatal infections in rural Southeast Asia (Bohol Island, Philippines)

et al. 2007

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Objective: To determine the bacterial etiology, clinical presentation and risk factors for outcome of serious community-acquired infections in young infants.Study Design: Infants younger than 60 days, admitted for severe pneumonia or suspected sepsis/meningitis were prospectively evaluated using complete blood count, blood culture, chest radiograph, cerebrospinal fluid (CSF) culture in suspected meningitis. w 2 or Fisher's exact test and stepwise logistic regression were used for analysis.Results: Thirty-four of 767 enrolled infants had a positive blood or CSF culture. Gram-negative bacteria were more frequent than Gram positive: overall (P ¼ 0.004), in those below 7 days of age (P ¼ 0.002) and among home deliveries (P ¼ 0.012). Case fatality rates were higher among infants below 1 week old (OR 4.14, P<0.001), those with dense (OR 2.92, P<0.001) or diffuse radiographic infiltrates (OR 2.79, P ¼ 0.003).Conclusions: Gram-negative enteric bacteria are the predominant causes of community-acquired infections in Filipino infants below 2 months old. Age below 7 days and radiographic pneumonia predicted death.

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“…This result is similar to that of other studies that showed that 44 Klebsiella species have often been isolated in hospital setting and are often implicated in nursery outbreaks. 45 Acinetobacter spp was the second most common organism isolated in this study.…”

Section: Discussionmentioning

confidence: 65%

Evaluation of hypoglycemic status and causative factors in neonatal sepsis

Islam

Aklima

Yesmin

et al. 2017

Int J Contemp Pediatr

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Background: Very few studies have been reported on hypoglycemic status, hematological parameters and causative organisms of neonatal sepsis in different regions of Bangladesh. Hence, present study was conducted in the Chittagong city of Bangladesh.Methods: The study was conducted on 106 neonates (0 to 28 days of age) in Chattagam Maa-Shishu O General Hospital, Bangladesh. The questionnaire was developed to get relevant information of the neonates. Blood from neonates were subjected to routine investigations like blood glucose, CRP, hematological parameters, blood culture and bacterial identification.Results: Among 106 neonates with sepsis, 68 presented early onset neonatal sepsis (EONS) and 38 presented late onset neonatal sepsis (LONS). Fifty-one neonates had low birth weight (2500 g or less), 18 had very low birth weight (1500 g or less) and 22 were preterm. The most prevalent clinical features were reluctant to feed (56), hyperthermia (31) and hypotonia (22). Thirty-three neonates had neutropenia (<54%) and 62 had higher neutrophil count (>62%). Biochemical analysis showed 52 had higher C-reactive protein levels. Investigation of hypoglycemic status revealed that there were different types of neonatal sepsis, i.e. 77 neonates were hypoglycemic (<45 gm/dl), and among them EONS and LONS were 59 and 18, respectively. Thirty-three neonates had positive blood culture for bacteria. Among them, Klebsiella spp. accounted for 10 of the total isolates followed by Acinetobacter spp. 8. The Gram-positive and negative bacteria were found in 7 and 26, respectively.Conclusions: Hypoglycemia was associated with neonatal sepsis as an exacerbating factor.

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Severe Klebsiella infection as a cause of mortality in neonates in Harare, Zimbabwe

Cited by 20 publications

References 0 publications

Morbidity and mortality of low birth weight infants in the New Born Unit of Kenyatta National Hospital, Nairobi

Morbidity and mortality of low birth weight infants in the New Born Unit of Kenyatta National Hospital, Nairobi

Serious community-acquired neonatal infections in rural Southeast Asia (Bohol Island, Philippines)

Evaluation of hypoglycemic status and causative factors in neonatal sepsis

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