Severe knee osteoarthritis patients show more femoral coronal bowing than moderate knee osteoarthritis patients – a study using three dimensional computed tomography

Shimosawa, H.; Nagura, Takeo; Kobayashi, Shū; Harato, Kengo; Nakamura, Masaya; Matsumoto, Morio; Niki, Yasuo

doi:10.1016/j.joca.2018.02.851

Cited by 2 publications

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“…The current data suggest that any additional benefits to whole-bone geometry are limited. Whilst greater femoral bowing of ∼ 2° has been found in the trained and in the older group in our study and could be interpreted as a risk factor for osteoarthritis which has been linked to an increased bowing of ∼3°–5° ( Matsumoto et al, 2015 ; Shimosawa et al, 2018 ). Additionally, the same magnitude of higher femoral bowing evident in master athletes is associated with increased risk of rare atypical femoral fractures ( Haider et al, 2019 ), its relationship with overall fracture risk is unknown.…”

Section: Discussionsupporting

confidence: 55%

“…In particular increased femoral torsion, in the order of magnitude of ∼6° can discern between an osteoarthritic and healthy hip in the same subject (Piazzolla, Solarino, et al, 2018) and increases the risk of hip impingement, and knee osteoarthritis ( Scorcelletti et al, 2020 ). Furthermore, Increased lateral femoral and tibial bowing in the order of magnitude of ∼3°–5° are also associated with increased incidence of knee osteoarthritis ( Matsumoto et al, 2015 ; Shimosawa et al, 2018 ), and femoral and tibial fractures ( Chen et al, 2014 ). Decreased acetabular version in the order of magnitude of ∼2°–6° and femoro-acetabular congruence have been shown to be relevant to hip osteoarthritis, dysplasia and impingement ( Tönnis and Heinecke, 1999 ; Fujii et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

“…In the upper limbs, research shows that baseball players have on average 10.6° greater humeral head retroversion (torsion) in the throwing arm (Chant, Litchfield et al, 2007). Femoral bowing might be increased by prolonged squatting tasks or decreased by prolonged heavy lifting tasks due to farming activity in the order of magnitude of 1°–3°( Do et al, 2020 ), which is clinically relevant for osteoarthritis ( Matsumoto et al, 2015 ; Shimosawa et al, 2018 ). Therefore, our primary aim was to examine the impact of continued participation in exercise during adulthood on lower limb geometry by comparing young and old sedentary individuals with young and old power athletes.…”

Section: Introductionmentioning

confidence: 99%

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Associations between long-term exercise participation and lower limb joint and whole-bone geometry in young and older adults

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Introduction: Features of lower limb bone geometry are associated with movement kinematics and clinical outcomes including fractures and osteoarthritis. Therefore, it is important to identify their determinants. Lower limb geometry changes dramatically during development, partly due to adaptation to the forces experienced during physical activity. However, the effects of adulthood physical activity on lower limb geometry, and subsequent associations with muscle function are relatively unexplored.Methods: 43 adult males were recruited; 10 young (20–35 years) trained i.e., regional to world-class athletes, 12 young sedentary, 10 older (60–75 years) trained and 11 older sedentary. Skeletal hip and lower limb geometry including acetabular coverage and version angle, total and regional femoral torsion, femoral and tibial lateral and frontal bowing, and frontal plane lower limb alignment were assessed using magnetic resonance imaging. Muscle function was assessed recording peak power and force of jumping and hopping using mechanography. Associations between age, training status and geometry were assessed using multiple linear regression, whilst associations between geometry and muscle function were assessed by linear mixed effects models with adjustment for age and training.Results: Trained individuals had 2° (95% CI:0.6°–3.8°; p = 0.009) higher femoral frontal bowing and older individuals had 2.2° (95% CI:0.8°–3.7°; p = 0.005) greater lateral bowing. An age-by-training interaction indicated 4° (95% CI:1.4°–7.1°; p = 0.005) greater acetabular version angle in younger trained individuals only. Lower limb geometry was not associated with muscle function (p > 0.05).Discussion: The ability to alter skeletal geometry via exercise in adulthood appears limited, especially in epiphyseal regions. Furthermore, lower limb geometry does not appear to be associated with muscle function.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations between long-term exercise participation and lower limb joint and whole-bone geometry in young and older adults

et al. 2023

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The Surprising Reach of FDA Regulation of Cannabis, Even after Descheduling

O’Connor

Lietzan

2018

SSRN Journal

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no currently accepted medical use in treatment in the United States"; and (3) "[t]here is a lack of accepted safety" for use of the drug or other substance under medical supervision. 8 Tetrahydrocannabinols (THC) and cannabimimetic agents (compounds that mimic the effects of cannabinoids) are also listed in Schedule I. 9 Manufacturing, distributing, dispensing, or possessing with the intent to do any of the foregoing is allowed under the CSA only for individuals who have been issued a so-called "Schedule I license." 10 These licenses are rare and hard to come by. 11 The Department of Justice (DOJ), and more specifically, the Drug Enforcement Agency (DEA) generally enforce the CSA. 12 Their actions with regard to illicit trade in drugs are usually perceived to be straightforward criminal prosecutions: "Miami Vice"-or "Cops"-style drug busts. 13 There is a misperception that such enforcement is not available in states with recreational or medical marijuana laws, at least with regard to state law-compliant cannabis enterprises. 14 The reality and risks associated with marijuana and its cannabinoids, ACP believes that it is time to review the evidence to determine whether reclassification is appropriate."). 8. § 812(b)(1)(A)-(C); see also infra Part II. 9. See § 812(c); § 812(d)(2)(A). 10. § § 821-823; Synthetic Drugs, Real Danger: Hearing Before the Subcomm. on Crime, Terrorism, Homeland Sec. & Investigations of the H. Comm. on the Judiciary, 114th Cong. 4 (2016) (statement of David Earl Nichols, Ph.D., Adjunct Professor of Chemical Biology and Medicinal Chemistry at the University of North Carolina at Chapel Hill, NC) ("Obtaining a Schedule I license is not a trivial matter. .. . [T]he investigator must have a strong personal belief that something useful will be discovered by their research that is of sufficient importance to justify the regulatory demands of a Schedule I license. To wit, a researcher must submit an application to the DEA that includes the investigator's scientific credentials, the description of the laboratory, a precise description of the work to be carried out, listing the specific substance to be used, and a calculation of how much substance will be needed and for how long. If the DEA determines that the. .. license is justified, there is then an inspection of the storage facility. .. to ensure that the controlled substance cannot be easily diverted. .. . Inventory and use must be documented, and there is a license fee for most non-public institutions.").

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Severe knee osteoarthritis patients show more femoral coronal bowing than moderate knee osteoarthritis patients – a study using three dimensional computed tomography

Cited by 2 publications

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Associations between long-term exercise participation and lower limb joint and whole-bone geometry in young and older adults

Associations between long-term exercise participation and lower limb joint and whole-bone geometry in young and older adults

The Surprising Reach of FDA Regulation of Cannabis, Even after Descheduling

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