Severe Leptospirosis in Hospitalized Patients, Guadeloupe

Herrmann-Storck, Cécile; Louis, Magalie Saint; Foucand, Tania; Lamaury, I.; Deloumeaux, Jacqueline; Baranton, Guy; Simonetti, Maurice; Sertour, Natacha; Nicolas, Muriel; Salin, Jacques; Cornet, Muriel

doi:10.3201/eid1602.090139

Cited by 58 publications

(71 citation statements)

References 9 publications

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“…Our findings corroborate other large case series that show that the most common clinical manifestation of leptosporisis are nonspecific signs or symptoms, such as fever, headache, and mylagias ( 5 , 22 , 25 – 27 ). The case-fatality rate (0.5%) is lower than that reported from Brazil ( 25 ), Barbados ( 28 ), Guadeloupe ( 22 ), and the Andaman Islands ( 26 ), but similar to the rates found in our earlier study ( 5 ) and in a recent case series from France ( 27 ).…”

Section: Discussionsupporting

confidence: 91%

“…The case-fatality rate (0.5%) is lower than that reported from Brazil ( 25 ), Barbados ( 28 ), Guadeloupe ( 22 ), and the Andaman Islands ( 26 ), but similar to the rates found in our earlier study ( 5 ) and in a recent case series from France ( 27 ). The low case-fatality rate in this series may be explained by early recognition and initiation of supportive therapy and antimicrobial drugs.…”

Section: Discussionsupporting

confidence: 87%

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Leptospirosis in Hawaii, USA, 1999–2008

Katz¹,

Buchholz²,

Hinson³

et al. 2011

Emerg. Infect. Dis.

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Although infrequently diagnosed in the United States, leptospirosis is a notable reemerging infectious disease throughout developing countries. Until 1995, when the disease was eliminated from the US list of nationally notifiable diseases, Hawaii led the nation in reported annual incidence rates. Leptospirosis remains a notifiable disease in Hawaii. To ascertain the status of leptospirosis in Hawaii since the most recent US report in 2002, we reviewed 1999–2008 data obtained from case investigation reports by the Hawaii State Department of Health. Of the 345 case reports related to in-state exposures, 198 (57%) were laboratory confirmed. Our findings indicate a change in seasonal disease occurrence from summer to winter and in the infective serogroup from Icterohemorrhagiae to Australis. Also, during the past 20 years, recreational exposures have plateaued, while occupational exposures have increased. Ongoing surveillance is needed to clarify and track the dynamic epidemiology of this widespread zoonosis.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 87%

Leptospirosis in Hawaii, USA, 1999–2008

Katz¹,

Buchholz²,

Hinson³

et al. 2011

Emerg. Infect. Dis.

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“…We based our classification of severity on treatment-related criteria to reflect everyday patient management, as previously reported ( 12 , 13 ). The fact that no patient died could be associated with factors such as reduced diagnosis time and early treatment.…”

Section: Resultsmentioning

confidence: 99%

Factors Associated with Severe Leptospirosis, Martinique, 2010–2013

Hochedez¹,

Théodose²,

Olive³

et al. 2015

Emerg. Infect. Dis.

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To identify factors associated with disease severity, we examined 102 patients with quantitative PCR–confirmed leptospirosis in Martinique during 2010–2013. Associated factors were hypotension, chest auscultation abnormalities, icterus, oligo/anuria, thrombocytopenia, prothrombin time <68%, high levels of leptospiremia, and infection with L. interrogans serovar Icterohaemorrhagiae/Copenhageni.

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“…A lower incidence of infection in children has been widely reported ( 6 , 12 , 25 , 26 , 30 , 31 ); the difference is likely due to increased environmental exposure to the bacteria among adults ( 3 , 4 ). …”

Section: Discussionmentioning

confidence: 99%