Severe Livedoid Vasculopathy Associated With Antiphosphatidylserine-Prothrombin Complex Antibody Successfully Treated With Warfarin

Noda, Shinichi; Asano, Yoshihide; Yamazaki, Masahide; Ichimura, Yohei; Tamaki, Zenshiro; Takekoshi, Tomonori; Sugaya, Makoto; Sato, Shinichi

doi:10.1001/archdermatol.2011.106

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…In our study (24 patients), 11 were tested positive for ACA and 6 patients positive for β 2GP1. This finding confirms previously published data (6,10,11), indicating that anti-phospholipid antibody plays an important role in the pathogenesis of LV. In addition, we noticed 2 unique clinical features of LV in Chinese patients.…”

Section: Discussionsupporting

confidence: 93%

Livedoid Vasculopathy: Clinical Features and Treatment in 24 Chinese Patients

Feng¹,

Wei²,

Jin³

et al. 2014

Acta Derm Venerol

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Livedo vasculopathy (LV) is a chronic cutaneous disorder characterised by recurrent, painful ulceration ending in stellate scars. We have conducted a retrospective study of clinical features and treatment response of LV in 24 Chinese patients. LV occurred more frequently in women (male:female ratio 1:3). The peak age at onset of disease ranged from 14 to 20 years, younger than previously published data. 87.5% of the patients (21/24) showed significant summer exacerbation with ulcer formation. Out of 24 patients tested, 14 (58.3%) had positive antiphospholipid antibodies. Ten out of 14 patients (71.4%) were tested to be hypersensitive to multivalent insect antigens. Combinative anti-inflammatory therapy with steroids, tetracycline and Tripterygium glycosides plus antiplatelet/profibrinolytic drugs promoted quick healing of ulcer and reduce recurrence. The younger age of disease presentation and significant summer exacerbation are 2 novel clinical features observed in this study. These findings suggest that apart from procoagulation other risk factors may contribute significantly to the pathogenesis of LV. Although antiplatelet/profibrinolytic drugs are deemed as a first line therapy for LV, anti-inflammatory medications such as steroids, tetracycline and Tripterygium glycosides, from our experiences, are indispensable, especially for acute, ulcerative stage of disease.

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Section: Discussionsupporting

confidence: 93%

Livedoid Vasculopathy: Clinical Features and Treatment in 24 Chinese Patients

Feng¹,

Wei²,

Jin³

et al. 2014

Acta Derm Venerol

View full text Add to dashboard Cite

show abstract

“…A literature review was conducted to determine the most appropriate treatment. [12][13][14][15][16][17][18][19][20][21][22][23][24] A number of therapies have been proposed, including anticoagulant, fibrinolytic, antiplatelet, immunosuppressant, and immunomodulator therapy, as well as hyperbaric oxygen; however, IVIG was felt to be the best option. 12-24 A number of studies supported the use of IVIG in the treatment of LV and demonstrated good outcomes 14,15,[21][22][23] with minimal adverse effects, 24 and it has been shown to benefit those with difficultto-treat LV.…”

Section: Thrombotic Vasculopathy In a Patient With Initially Undetectmentioning

confidence: 99%