“…In relation to the study design, 32 were cross-sectional studies, 2 were cohort studies and there were 6 case and control studies. With regard to the classification of studies included according to age group, 24 studies were performed in children [ 16 – 19 , 25 , 27 , 29 – 37 , 39 , 40 , 43 , 45 , 47 , 51 , 52 , 54 , 55 ], 10 were in adolescents [ 20 , 22 – 24 , 26 , 28 , 44 , 46 , 48 , 50 ], 4 were adult studies [ 21 , 38 , 42 , 53 ] and 2 study included more than one age group [ 41 , 49 ]. They all also evaluated the impact of oral disease over OHRQoL, classified according to exposure to one or more oral diseases, tooth decay, malocclusion, TDI, periodontal diseases, temporomandibular dysfunction, salivary gland pathologies, cleft lip and palate, and edentulism and found studies related to dental caries (n = 7) [ 20 , 25 , 32 , 36 , 37 , 43 , 54 ], malocclusion (n = 2) [ 24 , 26 ], TDI (n = 3) [ 29 , 39 , 44 ], periodontal disease (n = 1) [ 38 ], cleft lip and palate (n = 1) [ 40 ], temporomandibular dysfunction (n = 1) [ 41 ], edentulism (n = 1) […”