Severe manifestation of acute hepatitis A recently found in Gunma, Japan

Kanda, Daisuke; Takagi, Hitoshi; Hashimoto, Yoshiaki; Yamazaki, Yuichi; Matsui, Masayuki; Kosone, Takashi; Arai, Hajime; Ichikawa, Takeshi; Nakajima, Hiroaki; Otsuka, Toshiyuki; Kojima, Akira; Sato, Ken; Kakizaki, Satoru; Matsuzaki, Yutaka; Matsumoto, T; Shimoda, Ryuya; Kaneko, Mieko; Takayama, Hisashi; Takahashi, Hitomi; Abe, Takehiko; Takezawa, Jiro; Mori, Masataka

doi:10.1007/s005350200080

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…It is reported that age ≥40 years (OR 6.91, p = 0.002), hepatitis B surface antigen positivity (OR 5.02, p = 0.049), and peak total bilirubin (OR 1.11, p = 0.001) are significant risk factors for ALF. 97 Kanda et al 98 also reported that two of the three patients with fulminant hepatitis A between 1998 and 1999 in Gunma Prefecture were over 40 years-of-age. The outcomes of patients with ALF or LOHF caused by HAV infection have recently worsened, mainly because of an increase in underlying metabolic diseases as a consequence of aging, 96 and multivariate analysis revealed that patient age and disease type are significantly and independently associated with the outcome.…”

Section: Age Over 40 Yearsmentioning

confidence: 96%

Section: Consensus Statements and Recommendationsmentioning

confidence: 99%

“…Host factors Age ≥40 years [96][97][98][99] Genetic factors (SNPs) 102,104 Viral factors HAV viral loads 75,76,100,105 HAV genotypes 88,106,107,111,112 Nucleotide mutations 13,118 Other factors Co-infection of HIV 126 Existence of chronic liver disease 122,[127][128][129][130][131] Existence of metabolic diseases 96 Abbreviations: HIV, human immunodeficiency virus; SNPs, single-nucleotide polymorphisms.…”

Section: Items Factorsmentioning

confidence: 99%

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Recent advances in hepatitis A virus research and clinical practice guidelines for hepatitis A virus infection in Japan

Kanda,

Sasaki‐Tanaka,

Ishii

et al. 2023

Hepatology Research

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In 2018, there was a hepatitis A outbreak in Japan, and hepatitis A virus (HAV) infection is considered a sexually transmitted disease. In general, patients with hepatitis A should be given attention, and this disease should be prevented more than ever. The Japan Agency for Medical Research and Development (AMED) Hepatitis A and E viruses (HAV and HEV) Study Group has worked on the project to create “Recent Advances in Hepatitis A Virus (HAV) Research and Clinical Practice Guidelines for HAV Infection in Japan”. The group consists of expert hepatologists and virologists who gathered at virtual meeting on August 5, 2023. Data about the pathogenesis, infection routes, diagnosis, complications, several factors for the severities, vaccination, and current and future treatments for hepatitis A were discussed and debated for a draft version. The participants assessed the quality of cited studies. The finalized recommendations are presented in this review. The recent advances in HAV research and clinical practice for HAV infection in Japan, have been reviewed by the AMED HAV and HEV Study Group.

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Section: Age Over 40 Yearsmentioning

confidence: 96%

Section: Consensus Statements and Recommendationsmentioning

confidence: 99%

Section: Items Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in hepatitis A virus research and clinical practice guidelines for hepatitis A virus infection in Japan

Kanda,

Sasaki‐Tanaka,

Ishii

et al. 2023

Hepatology Research

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“…Only few persons are infected in early childhood, and the majority of adults thus remain susceptible to infection, which may lead to the occurrence of outbreaks of hepatitis A among the general population. The fatality rate in HAV infections is lower than 0·1%, although recent HAV outbreaks tend to be more severe (Kanda et al. 2002), e.g.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis A virus detection in food: current and future prospects

Sánchez

Bosch

Pintó

2007

Lett Appl Microbiol

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Summary Hepatitis A virus (HAV) is responsible for around half of the total number of hepatitis infections diagnosed worldwide. HAV infection is mainly propagated via the faecal‐oral route and as a consequence of globalisation, transnational outbreaks of foodborne infections are reported with increasing frequency. Molecular procedures are now available and should be employed for the direct surveillance of HAV in food and environmental samples.

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