Severe maxillofacial renal osteodystrophy in two patients with chronic kidney disease

Lopes, Maria Luiza Diniz de Sousa; Albuquerque, Assis Filipe Medeiros; Germano, Adriano Rocha; Queiroz, Lélia Maria Guedes; Miguel, Márcia Cristina da Costa; Silveira, Éricka Janine Dantas da

doi:10.1007/s10006-015-0490-9

Cited by 12 publications

(5 citation statements)

References 22 publications

(47 reference statements)

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“…Radiographic changes in RO are similar to the changes observed in fibrous dysplasia or Paget's disease. This pathophysiology is consistent with ground-glass bone appearance, hypercementosis and bone resorption with loss of the lamina dura [25]. The latter is a common dental radiographic feature for all high-turnover metabolic bone diseases.…”

Section: Dental Manifestationssupporting

confidence: 75%

Dental Manifestations of Pediatric Bone Disorders

Yepes

2017

Curr Osteoporos Rep

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Section: Dental Manifestationssupporting

confidence: 75%

Dental Manifestations of Pediatric Bone Disorders

Yepes

2017

Curr Osteoporos Rep

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“…Bakathir et al [15] described the progressive enlargement of facial bones of a 21-year-old female uremic patient whose facial enlargement involved the maxilla and caused facial and dental deformities. Lopes et al [16] presented two female uremic patients with facial disfigurement affecting the maxilla and the mandible. Raubenheimer et al [17] also reported two female uremic cases with extensive jaw lesions due to secondary hyperparathyroidism.…”

Section: Discussionmentioning

confidence: 99%

Survey of Torus Palatinus in Patients with End-Stage Renal Disease Undergoing Hemodialysis

Tai

Hsu

Tsai

et al. 2018

BioMed Research International

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Introduction This study attempted to survey the oral findings of hemodialysis patients and analyze the prevalence and predictors for torus palatinus (TP) in this patient population. Methods A total of 322 hemodialysis patients were recruited. Patients were organized into two groups, based on the presence (n=93) or absence (n=229) of TP. Demographic, laboratory, and dialysis-related data were obtained for analysis. Results The prevalence of TP was 28.9% in this study. Patients with TP were younger in age [57.8±10.0 (37.4-86.9) versus 62.4±12.3 (25.0-87.8) years old; P=0.001] and predominantly female (60.2% versus 38.0%; P<0.001), compared to patients without TP. All TPs (100.0%) were symmetrical and located along the midpalatal suture. Most TPs were flat-shaped (55.9%) and near premolars (78.5%). The blood tests revealed higher blood concentrations of phosphate (5.4±1.1 versus 4.9±1.1 mg/dL; P=0.001) and lower blood concentrations of bicarbonate (20.9±2.4 versus 22.0±2.3 mmol/L; P<0.001) in patients with TP. Multivariate regression modeling showed that younger age [odds ratio (OR) 0.968; 95% confidence interval (CI) 0.939–0.982; P<0.001], female gender (OR 2.305; 95% CI 1.374–3.867; P=0.002), higher blood concentration of phosphate (OR 1.411; 95% CI 1.110–1.794; P=0.005), and lower blood concentration of bicarbonate (OR 0.868; 95% CI 0.791–0.994; P=0.040) were significant predictors for TP. Conclusion The prevalence of TP is 28.9%, and the majority of patients suffering TP are female. Younger age, female gender, elevated blood concentration of phosphate, and lower blood concentration of bicarbonate are predictors for TP.

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“…Renal bone disease causes cranial and maxillofacial appearance changes due to maxillary fibrosis deformity. Lopes et al 29 reported two cases of severe renal osteodystrophy affecting the maxilla and mandible, ultimately causing facial disfigurement in a young female patient with CKD and a middle-aged female patient with CKD. Severe bone changes in the skull and maxillofacial face are accompanied by abnormal bone metabolism in other sites, which are characterized as Sagliker syndrome 4 .…”

Section: Discussionmentioning

confidence: 99%

Biomechanical and histomorphological analysis of the mandible in rats with chronic kidney disease

Hu,

Chen,

Shao

et al. 2023

Sci Rep

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The present study aimed to investigate the biomechanical and histomorphological features of mandibles in an adenine-induced chronic kidney disease–mineral and bone disorder (CKD-MBD) rat model of CKD. A total of 14 Sprague-Dawley rats were randomized into the following two groups: control group and CKD group. At the end of the sixth week, all rats were euthanized, and serum was collected for biochemical marker tests. Macroscopic bone growth and biomechanical parameters were measured in the right hemimandible, while the left hemimandible was used for bone histomorphometric analysis. Compared to the control group, the CKD group showed a significant increase in serum creatinine, blood urea nitrogen, and serum parathyroid hormone at the end of the sixth week. The biomechanical structural properties significantly decreased in the CKD group compared to the control group. Bone histomorphometric analysis indicated that the trabecular bone volume of rats in the CKD group was significantly lower than that of the control group. In the CKD groups, the bone formation parameters of the trabecular bone were significantly increased, while the bone mineralization apposition rates of both the trabecular bone and periosteal cortical bone were significantly increased. The rat CKD model showed deteriorated structural mechanics, low trabecular bone volume, high trabecular bone formation, increased trabecular bone mineralization apposition rate, and increased cortical bone mineralization apposition rate, which met the characteristics of osteitis fibrosa, indicating that this model is a useful tool for the study of mandible diseases in CKD patients.

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Severe maxillofacial renal osteodystrophy in two patients with chronic kidney disease

Cited by 12 publications

References 22 publications

Dental Manifestations of Pediatric Bone Disorders

Dental Manifestations of Pediatric Bone Disorders

Survey of Torus Palatinus in Patients with End-Stage Renal Disease Undergoing Hemodialysis

Biomechanical and histomorphological analysis of the mandible in rats with chronic kidney disease

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