Severe Mental Disorders in Offspring With 2 Psychiatrically Ill Parents

Abstract

Derived risks may be informative for counseling. Patterns of transmission may support evolving assumptions about genetic overlap for traditional categories.

The predictive value of childhood subthreshold manic symptoms for adolescent and adult psychiatric outcomes

“…Although parental BD is a robust indicator of concordant offspring disorder (Duffy et al, 2010;Gottesman et al, 2010), we did not focus on individual parental diagnoses as risk elevation is not confined to concordant disorders (Dean et al, 2010). Therefore in subsequent analyses parental psychopathology was collapsed into a single variable and was considered absent or present regardless of the individual parental diagnoses.…”

Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder and major depressive disorder: a meta-analysis of family high-risk studies

“…This confirms results from population registry and genetic studies that report overlap of familial and genetic risk to various mental disorders. 2,3,25 The results of the meta-analysis also suggest that familial transmission can be heterotypic (different from parent diagnosis), yet diagnosis specific: the risk of anxiety disorders was elevated in offspring of parents with bipolar disorder or depression, but not in offspring of parents with schizophrenia. The heterotypic familial transmission supports recent findings from molecular genetic analyses suggesting shared genetic factors underlying schizophrenia, bipolar disorder and major depression.…”

“…[1][2][3][4] Individuals with SMI want to know the probability that their offspring will develop SMI. Accurate quantification of risk is an important element in communication with patients and their families.…”

Genetics of Schizophrenia and other Psychotic Disorders

“…Recently, large scale epidemiological studies from Scandinavia, which have linked national population registers with mental health service registers, have provided further information on the patterns of familial risks. One such study found the risk of schizophrenia in the offspring of couples who had both been admitted to a psychiatric facility with a diagnosis of schizophrenia was 27.3% (increasing to 39.2% when schizophrenia-related disorders were included) [4]. This was compared with a risk of schizophrenia of 7% in the offspring of couples with only one parent ever admitted for schizophrenia and 0.9% in the offspring of couples where neither had ever been admitted [4].…”