Severe metabolic acidosis and heart failure due to thiamine deficiency

Ozawa, Hideki; Homma, Yasuhiko; Arisawa, Hisako; Fukuuchi, F; Handa, S

doi:10.1016/s0899-9007(00)00588-8

Cited by 31 publications

(32 citation statements)

References 4 publications

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“…• shoshin béribéri : forme où prédomine une atteinte cardiaque fulminante avec état de choc, associée à une acidose lactique le plus souvent majeure d'évolution rapidement fatale [1,2,4,7,[9][10][11]27,31,33,39] ;…”

Section: Définitionsunclassified

Shoshin béribéri: réémergence d’une pathologie ancienne ? À propos d’une série de 11 cas à Mayotte

Restier

Carsalade²,

Abdou³

et al. 2011

Bull. Soc. Pathol. Exot.

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In the French island of Mayotte in the Indian Ocean, the health and food situation remains contrasted. For a very long time dry beriberi women in postpartum had been suspected and treated. But in 2004 the first infantile epidemic of beriberi was scientifically authenticated and a program of thiaminic supplementation for the pregnant women and infants was set up. In this context, we describe an epidemic of 11 cases of shoshin beriberi among adults between January 2008 and Februar 2009. Over 11 cases of shoshin beriberi, 5 cases were confirmed biologically and 6 were probable. The sex ratio M/W was 0.37. The median age was 34 years. The clinic picture was typical: severe acute dyspnea, an agitation/drowsiness, right cardiac failure: polynevritis of the lower limbs was noted in 9 cases over 11. Biologically it was characterized by a lactic acidosis (average pH: 7.08, lactates: 12.08 mmol/l). The evolution was favorable in the 8 cases which could benefit from early thiaminic refill. The outbreak of an epidemic of shoshin beriberi among adults mainly in groups not having benefited from supplementation shows the effectiveness of the program but also its limits. We compare our series with others: the period from April to June when the food is less diversified, is confirmed as a higher risk period. The programs of nutritional education must be increased and a B1 vitamin supplementation for broader people during the rain season might be discussed.

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Section: Définitionsunclassified

Shoshin béribéri: réémergence d’une pathologie ancienne ? À propos d’une série de 11 cas à Mayotte

Restier

Carsalade²,

Abdou³

et al. 2011

Bull. Soc. Pathol. Exot.

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“…Cappelli et al (5) have shown evidence that supports the view that cardiac contractility is deeply affected in the rat by thiamine deficiency. Thiamine is also considered a clinically important factor in heart function, and its deficiency has been reported to cause heart failure (28,33,35). The general view that reperfusion of the ischemic myocardium exerts a beneficial effect by preventing the ischemiainduced changes in cardiac performance has been supported by a number of studies; however, reperfusion after a certain critical time has been shown to be deleterious to cardiac function (16).…”

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confidence: 99%

Abolition of reperfusion-induced arrhythmias in hearts from thiamine-deficient rats

Oliveira¹,

Guatimosim²,

Castro³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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tensive work has been done regarding the impact of thiamine deprivation on the nervous system. In cardiac tissue, chronic thiamine deficiency is described to cause changes in the myocardium that can be associated with arrhythmias. However, compared with the brain, very little is known about the effects of thiamine deficiency on the heart. Thus this study was undertaken to explore whether thiamine deprivation has a role in cardiac arrhythmogenesis. We examined hearts isolated from thiamine-deprived and control rats. We measured heart rate, diastolic and systolic tension, and contraction and relaxation rates. Whole cell voltage clamp was performed in rat isolated cardiac myocytes to measure L-type Ca 2ϩ current. In addition, we investigated the global intracellular calcium transients by using confocal microscopy in the line-scan mode. The hearts from thiaminedeficient rats did not degenerate into ventricular fibrillation during 30 min of reperfusion after 15 min of coronary occlusion. The antiarrhythmogenic effects were characterized by the arrhythmia severity index. Our results suggest that hearts from thiamine-deficient rats did not experience irreversible arrhythmias. There was no change in L-type Ca 2ϩ current density. Inactivation kinetics of this current in Ca 2ϩ -buffered cells was retarded in thiamine-deficient cardiac myocytes. The global Ca 2ϩ release was significantly reduced in thiaminedeficient cardiac myocytes. The amplitude of caffeine-releasable Ca 2ϩ was lower in thiamine-deficient myocytes. In summary, we have found that thiamine deprivation attenuates the incidence and severity of postischemic arrhythmias, possibly through a mechanism involving a decrease in global Ca 2ϩ release.arrhythmia; calcium current; confocal microscopy THIAMINE DEFICIENCY CAUSES cardiovascular and neurological damage that presents clinically as beriberi. Thiamine pyrophosphate is an important cofactor in several vital enzymatic reactions involved in metabolism and energy production (34, 39). Following its uptake by the cell, thiamine rapidly undergoes pyrophosphorylation, yielding thiamine pyrophosphate, which is the active substance. Extensive work has been done regarding the impact of thiamine deprivation on the nervous system. However, very little is known about the effects of thiamine deficiency on the myocardium (5). Cappelli et al. (5) have shown evidence that supports the view that cardiac contractility is deeply affected in the rat by thiamine deficiency. Thiamine is also considered a clinically important factor in heart function, and its deficiency has been reported to cause heart failure (28, 33, 35). The general view that reperfusion of the ischemic myocardium exerts a beneficial effect by preventing the ischemiainduced changes in cardiac performance has been supported by a number of studies; however, reperfusion after a certain critical time has been shown to be deleterious to cardiac function (16). Intracellular Ca 2ϩ has an important role in heart function, and studies have been conducted to investigate pos...

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“…Palm oil delivers pro-vitamin A. Other rich sources of pro-vitamin A are carrots, sweet potato, tomato, mango, paw paw and dark green leafy vegetables [42]. This probably explained why vitamin A intakes of the mothers were close to the reference intake value.…”

Section: Discussionmentioning

confidence: 99%

Food insecurity and nutritional status of mothers in Abia and Imo states, Nigeria.

2017

Int. J. Adv. Res. Biol. Sci

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Background: Food insecurity is a global problem especially in developing countries where most people are estimated to be malnourished. Objective: The study assessed at food insecurity and nutritional status of mothers in Abia and Imo States, Nigeria. Methods: The cross-sectional study was carried out on 600 households which were randomly selected from 30 communities from the study area. Validated and pre-tested questionnaire was used to elicit information on household basic and health characteristics and food security status of the households. Mean nutrient intakes of mothers were calculated from weighed food intake carried out on 10% of food insecure households. The results were compared with FAO/WHO reference nutrient intakes. Body mass indices of the mothers were calculated from measured weights and heights and compared with WHO reference standard. Basic and health characteristics of households, socio-economic of respondents and food security status of households were analyzed using SPSS version 20. Logistic regression of food security against household size, mother's income and educational status was done. Simple regression of household food security against body mass indices of mothers was carried out. Results: Household size ranged from 1-2 (15.8%) to >7 (15.8%) while 87.7% of the households were headed by males and the rest (12.3%) females. The mean nutrient intakes of mothers from low and moderate food insecurity households were higher than reference nutrient intake values for energy, carbohydrate, fat, fiber, calcium, iodine and vitamin C. It was lower than the RNI for protein, iron, zinc, niacin, riboflavin, thiamin, folic acid and vitamin A. Some respondents (33.6%) were in the normal BMI range while 19.4% and 47.0% were underweight and overweight, respectively. There was a weak relationship between food insecurity and household head (odds : 1.032), household size (odds: 1.132) and income of mothers (odds: 0.418). There was a significant positive relationship (t=13430, p< 0.05) between food insecurity and body mass indices f mothers. Conclusion: Household food insecurity is one of the factors affecting nutrition security and may have contributed to the malnutrition observed among mothers in the households studied.

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Severe metabolic acidosis and heart failure due to thiamine deficiency

Cited by 31 publications

References 4 publications

Shoshin béribéri: réémergence d’une pathologie ancienne ? À propos d’une série de 11 cas à Mayotte

Shoshin béribéri: réémergence d’une pathologie ancienne ? À propos d’une série de 11 cas à Mayotte

Abolition of reperfusion-induced arrhythmias in hearts from thiamine-deficient rats

Food insecurity and nutritional status of mothers in Abia and Imo states, Nigeria.

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