Severe multiresistant Salmonella typhimurium systemic infections in Central Africa - clinical features and treatment in a paediatric department

Lepage, P; Bogaerts, J.; Nsengumuremyi, F; Hitimana, D.G.; Goethem, C. Van; Vandepitte, J.; Butzler, Jean‐Paul

doi:10.1093/jac/14.suppl_b.153

Cited by 34 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although still effective in vitro, the trend for the three drugs is of concern. Similarly, a high prevalence of multiresistant Typhimurium was reported from Zaire [12], Central Africa [13] and Malawi [15]. In most multiresistant Typhimurium outbreaks in Africa, third-generation cephalosporins and ciprofloxacin were effective in treatment.…”

Section: Discussionmentioning

confidence: 95%

Analysis of Salmonella enterica serotype Typhimurium by phage typing, antimicrobial susceptibility and pulsed-field gel electrophoresis

Kariuki

Gilks

Kimari

et al. 1999

Journal of Medical Microbiology

View full text Add to dashboard Cite

Three typing methods commonly used for bacteria -phage typing, antimicrobial susceptibility and pulsed-field gel electrophoresis (PFGE) -were used to characterise 64 Salmonella enterica serotype Typhimurium isolates from individual adult patients from Nairobi, Kenya. The isolates encompassed 11 definitive phage types (DTs), which fell into eight PFGE clusters; 31.3% of isolates were either untypable or reacted nonspecifically with the phages used for typing and 26.6% were of DT 56. Plasmids of c. 100 kb were responsible for self-transferable multiresistance among the isolates. Analysis by PFGE and phage type demonstrated that multiresistant Typhimurium strains causing diarrhoea and invasive disease were multiclonal.

show abstract

Section: Discussionmentioning

confidence: 95%

Analysis of Salmonella enterica serotype Typhimurium by phage typing, antimicrobial susceptibility and pulsed-field gel electrophoresis

Kariuki

Gilks

Kimari

et al. 1999

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…Typhoid fever is a disease which requires new approaches for chemotherapy to overcome the problems of drug resistance and high relapse rates with this illness in different parts of the world (3,11,21,25,43). Plasmid-mediated resistance to chloramphenicol, ampicillin, and other agents presently used to treat systemic salmonellosis is an ever-present problem.…”

Section: Discussionmentioning

confidence: 99%

Oral ciprofloxacin treatment for Salmonella typhimurium infection of normal and immunocompromised mice

Brünner

Zeiler

1988

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Oral treatment of Salmonella typhimurium infection with ciprofloxacin was compared with conventional chemotherapy with ampicillin or chloramphenicol in normal (CFW1) and immunocompromised (C57BL/6) mice. Administration of the antibiotics for 12 days reduced the number of bacteria in livers and the mortality of C57BL/6 mice significantly. Ciprofloxacin was considerably more effective than ampicillin in prolongation of the mean survival time of these mice. Similar to conventional chemotherapeutic agents, ciprofloxacin did not prevent fatal disease in most C57BL/6 mice when the treatment lasted 12 days only. On the other hand, ciprofloxacin cured lethal S. typhimurium illness in immunocompromised mice after long-term oral chemotherapy for 26 days at a dosage of 100 mg/kg twice a day. This was not achieved by either ampicillin or chloramphenicol. In normal mice, 12 days of therapy with ciprofloxacin was sufficient for a significant decrease in both the number of viable bacteria in livers and the mortality of lethally infected mice. The results provide a basis for an alternative antibiotic treatment by the oral route in immunocompromised hosts with systemic infections.

show abstract

“…organisms has been associated with a very high There is also some evidence that these m u l t i -c a s e -f a t a l i t y -r a t e (7). The present study describes resistant Salmonella are more communicable and the focal metastatic manifestations of MRST virulent than the sensitive strains (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 58%

Metastatic focal infections due to multiresistant Salmonella typhimurium in children: A 34 month experience in Rwanda

et al. 1986

Self Cite

View full text Add to dashboard Cite

Nineteen out of 139 children with severe systemic disease due to multiresistant Salmonella typhimurium observed during a 34-month period in an in-patient department in Rwanda had focal metastatic infections. More than 80% of the invasive Salmonella infections were acquired in the hospital. Focal metastatic infections occurred after longer hospital stays than bacteremia (29.1 +/- 17.4 days as against 13.5 +/- 9.0 days, p less than 0.01) and were diagnosed more time after the first sign of infection (3.28 +/- 1.41 days as against 1.86 +/- 1.10 days, p less than 0.01). Bacteremia was documented in 13 of the 17 children with focal infection from whom blood cultures were obtained. Seven of 12 had positive stool cultures. The sites of metastatic focal infection were meninges (7 cases), soft tissue (5 cases), joint or bone (4 cases), pleura (2 cases), eye (1 case). The clinical course of meningitis was fulminant and 6/7 patients died before receiving adequate antimicrobial therapy. One child with meningitis and 9 patients with focal infections at other sites were treated with cefotaxime and were cured or improved.

show abstract

Severe multiresistant Salmonella typhimurium systemic infections in Central Africa - clinical features and treatment in a paediatric department

Cited by 34 publications

References 0 publications

Analysis of Salmonella enterica serotype Typhimurium by phage typing, antimicrobial susceptibility and pulsed-field gel electrophoresis

Analysis of Salmonella enterica serotype Typhimurium by phage typing, antimicrobial susceptibility and pulsed-field gel electrophoresis

Oral ciprofloxacin treatment for Salmonella typhimurium infection of normal and immunocompromised mice

Metastatic focal infections due to multiresistant Salmonella typhimurium in children: A 34 month experience in Rwanda

Contact Info

Product

Resources

About