Severe Mycoplasma Pneumoniae Infection in Children Admitted to Pediatric Intensive Care

Moynihan, Katie; Barlow, Andrew; Nourse, Clare; Heney, Claire; Schlebusch, Sanmarié; Schlapbach, Luregn J.

doi:10.1097/inf.0000000000002029

Cited by 26 publications

(24 citation statements)

References 8 publications

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“…M. pneumoniae causes upper and lower RTI and has been shown to be the most common bacterial pathogen for community-acquired pneumonia together with Streptococcus pneumoniae (2,3). M. pneumoniae-associated RTIs are most often mild and self-limiting in nature, and severe courses of disease are not common (4,5). In the past, the detection of pathogenspecific IgM and IgG antibodies in serum has been the standard diagnostic test for M. pneumoniae RTI.…”

Section: Introductionmentioning

confidence: 99%

Mycoplasma pneumoniae detection in children with respiratory tract infections and influence on management – a retrospective cohort study in Switzerland

et al. 2019

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Aim: To evaluate the frequency of Mycoplasma pneumoniae in nasopharyngeal specimens from children with respiratory tract infections (RTIs) and to detail clinical characteristics and management. Methods:The study was designed as a retrospective cohort study. All children with RTI and nucleic acid amplification testing from nasopharyngeal specimens were analysed. Clinical data were extracted from electronic health records for all M. pneumoniae-positive cases. Stored samples of cases and a random selection of matched controls were retested using a M. pneumoniae-specific nucleic acid amplification test.Results: Of 4460 children, 70 (1.6%) were positive for M. pneumoniae with a median age of 6.4 (IQR: 2.7-9.7). M. pneumoniae was the only organism identified in 50/64 (78%) cases. Macrolide treatment was prescribed in 52/65 (80%); prescription was empirical in 29/52 (56%) and targeted in 23/52 (44%) with no difference regarding patient age, oxygen requirement or duration of hospitalisation. Conclusion:The prevalence of M. pneumoniae in nasopharyngeal specimens of children with RTI was low. The detection of M. pneumoniae influenced antibiotic prescriptions, but the benefit of early empirical versus targeted treatment remains unclear.

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Section: Introductionmentioning

confidence: 99%

Mycoplasma pneumoniae detection in children with respiratory tract infections and influence on management – a retrospective cohort study in Switzerland

et al. 2019

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“…M. pneumoniae pneumonia (MPP) accounts for up to 40% or more of CAP in children, increasing the rate of morbidity, mortality, as well as the cost of health care in China [5][6][7][8] . Although MPP is usually a benign and self-limited disease, a number of cases had been reported to develop into refractory MPP 5,[9][10][11][12] . Furthermore, more than a third of refractory MPP were found to have bronchial mucus plugs (BMP) formation 9 .…”

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confidence: 99%

Nomogram for Prediction of Bronchial Mucus Plugs in Children with Mycoplasma pneumoniae Pneumonia

Sheng

et al. 2020

Sci Rep

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the presence of bronchial mucus plugs (BMp) in children with Mycoplasma pneumoniae pneumonia (MPP) results in delayed clinical and radiographic resolution and long-standing pulmonary sequelae. The predictive factors associated with BMP formation remains poorly defined. Nomograms to predict BMp presence in children with Mpp were proposed using a cohort of patients who underwent bronchoscopy intervention at Children's Hospital in Eastern China. Patients with MPP in an earlier period formed the training cohort (n = 872) for nomogram development, and those thereafter formed the validation cohort (n = 399) to confirmed model's performance. BMP in children with MPP were found in 196 (22.5%) and 91(22.8%) patients in the training and validation cohorts, respectively. the independent risk factors associated with BMp were age >5years (OR 2.06; 95% CI 1.43 to 2.98), higher IL-10 level (>10 ng/L, 2.19; 95% CI 1.46 to 3.28), higher IFN-γ level (>30 ng/L, 1.69; 95% CI 1.13 to 2.54), and presence of complication (3.43; 95% CI 1.45 to 8.09). Incorporating these 4 factors, the nomogram achieved good concordance indexes of 0.771(95% CI, 0.734-0.808) and 0.796 (95% CI, 0.744-0.848) in predicting BMP in the training and validation cohorts, respectively. The nomogram achieved an optimal prediction of BMP in children with MPP. Using this model, the risk of BMP formation would be determined, contributing to a rational therapeutic choice.

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“…pneumoniae is one of the common pathogens leading to community-acquired pneumonia. It can occur at any age, but adolescents are predominantly affected [11]. The rate of hospitalization in PICU is quite low, but some severe cases are described [11,12].…”

Section: Corbisier Et Almentioning

confidence: 99%

“…It can occur at any age, but adolescents are predominantly affected [11]. The rate of hospitalization in PICU is quite low, but some severe cases are described [11,12]. Viral co-infection is known to be frequent (27%) with M. pneumoniae and the hypothesis of a co-infection with COVID-19 was not unlikely [11,13].…”

Section: Corbisier Et Almentioning

confidence: 99%

Mycoplasma pneumoniae Infection in a 13-Year-Old Girl With Down’s Syndrome During the COVID-19 Pandemic

et al. 2020

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We report the case of a 13-year-old girl with Down's syndrome who presented with cough, fever, and a rapidly evolving respiratory failure leading to intensive care unit transfer during coronavirus disease 2019 (COVID-19) outbreak in Belgium. COVID-19-related acute respiratory distress syndrome (ARDS) is rare in teenagers and its diagnosis remains challenging as reverse transcription-polymerase chain reaction (RT-PCR)-testing sensitivity and radiological criteria still have to be defined in that population. We finally concluded to severe Mycoplasma pneumoniae infection. This case report gives the opportunity to discuss the rare occurrence of that disease, and to review the radiological findings of M. pneumoniae-and COVID-19-related pneumonia in teenagers.

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Severe Mycoplasma Pneumoniae Infection in Children Admitted to Pediatric Intensive Care

Cited by 26 publications

References 8 publications

Mycoplasma pneumoniae detection in children with respiratory tract infections and influence on management – a retrospective cohort study in Switzerland

Mycoplasma pneumoniae detection in children with respiratory tract infections and influence on management – a retrospective cohort study in Switzerland

Nomogram for Prediction of Bronchial Mucus Plugs in Children with Mycoplasma pneumoniae Pneumonia

Mycoplasma pneumoniae Infection in a 13-Year-Old Girl With Down’s Syndrome During the COVID-19 Pandemic

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