Severe Myopathy After Status Asthmaticus

MacFarlane, I. A.; Rosenthal, F. D.

doi:10.1016/s0140-6736(77)91471-4

Cited by 241 publications

(103 citation statements)

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“…10,11 Several animal and clinical studies have attributed the occurrence of ACM to the use of high doses of corticosteroids in a short period of time. [13][14][15][16][17][18][19][22][23][24] Nava et al, 22 in their rat model, showed that i.v. MP 80 mg/kg/ day for 5 days could induce severe limb and respiratory muscle wasting and predominantly type IIb muscle atrophy.…”

Section: Discussionmentioning

confidence: 99%

High-dose methylprednisolone may cause myopathy in acute spinal cord injury patients

Guo²,

et al. 2004

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Study design: Prospective cohort study. Objective: Although Bracken et al have demonstrated a significant neuroprotective effect of high-dose intravenous (i.v.) methylprednisolone (MP) within 8 h post spinal cord injury (SCI), this practice has recently been challenged. We hypothesized it is possible that acute corticosteroid myopathy (ACM) may occur secondary to the MP. This pilot study was performed to test this hypothesis. Setting: University of Miami School of Medicine/Jackson Memorial Hospital, Miami VA Medical Center, FL, USA. Methods: Subjects included five nonpenetrating traumatic SCI patients, who received 24 h MP according to National Acute Spinal Cord Injury Studies (NASCIS) protocol, and three traumatic patients who suffered SCI and did not receive MP. Muscle biopsies and electromyography (EMG) were performed to determine if myopathic changes existed in these patients. Results: Muscle biopsies from the SCI patients who received 24 h of MP showed muscle damage consistent with ACM in four out of five cases. EMG studies demonstrated myopathic changes in the MP-treated patients. In the three patients who had SCI but did not receive MP, muscle biopsies were normal and EMGs did not reveal evidence of myopathy. Conclusion: Our data suggest that MP in the dose recommended by the NASCIS may cause ACM. If this is true, part of the improvement of neurological recovery showed in NASCIS may be only a recording of the natural recovery of ACM, instead of any protection that MP offers to the injured spinal cord. Sponsorship:

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Section: Discussionmentioning

confidence: 99%

High-dose methylprednisolone may cause myopathy in acute spinal cord injury patients

Guo²,

et al. 2004

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“…The acute quadriplegic myopathy in ICU patients, originally reported by MacFarlane and Rosenthal in 1977, 9 was initially regarded as a rare event of limited clinical significance. However, recent prospective and retrospective studies have shown that this is an under-appreciated entity, which is a significant source of morbidity in the ICU, and has significant economic consequences on the usage of health resources.…”

Section: Discussionmentioning

confidence: 99%

Acute quadriplegic myopathy following autologous peripheral blood stem cell transplantation for breast cancer

Samuelsson¹,

Zackrisson

Tokics³

et al. 1999

Bone Marrow Transplant

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Summary:Autologous peripheral blood stem cell transplantation (APSCT) is increasingly used in the treatment of breast cancer. We report a patient who experienced septic shock, and after treatment with antibiotics, high-dose corticosteroids and mechanical ventilation due to respiratory insufficiency, developed quadriplegia. Electroneurophysiological examination, as well as a muscle biopsy, showed a typical picture of acute quadriplegic myopathy with loss of thick filament proteins. This is, to the best of our knowledge, the first reported case of this complication following APSCT.

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“…In addition, corticosteroids are the main determinants of impaired ability to exercise at 3 months in patients with critical illness myopathy [5]. After the first case report of profound frailty in asthma patients treated with corticosteroids and neuromuscular blocking agents [45], many similar findings were reported indicating that these two substances [28,46] contribute to CIP/CIM or ICUAW. In animal studies, denervated and steroid-treated animals showed muscle changes similar to those observed in critical patients [47].…”

Section: Risk Factors For Icuawmentioning

confidence: 94%

Skeletal Muscle Dysfunction in Critical Illness

Iida¹,

Sakuma²

2017

Physical Disabilities - Therapeutic Implications

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Despite improvements in critical illness survival rates with recent developments in medical care, many patients still have long-term physical disabilities following stays in the intensive care unit (ICU). Critical illness-induced muscle weakness, so-called ICU-acquired weakness (ICU-AW), is a common occurrence in approximately 50% of critically ill patients in the ICU requiring mechanical ventilation for >7 days. ICU-AW contributes to increases in duration of mechanical ventilation and lengths of ICU and hospital stays and may persist among survivors for several years after discharge. Risk factors for ICU-AW include systemic inflammatory responses, severe sepsis, muscle inactivity, hyperglycemia, and use of neuromuscular blockers. Thus, the development of muscle wasting is suggested to be associated with pathophysiological alterations leading to an imbalance between muscle proteolysis and proteosynthesis through several cellular signaling networks. This chapter presents a review of the literature regarding critical illness-induced muscle wasting and describes potential treatment of excessive muscle catabolism.

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Severe Myopathy After Status Asthmaticus

Cited by 241 publications

References 1 publication

High-dose methylprednisolone may cause myopathy in acute spinal cord injury patients

High-dose methylprednisolone may cause myopathy in acute spinal cord injury patients

Acute quadriplegic myopathy following autologous peripheral blood stem cell transplantation for breast cancer

Skeletal Muscle Dysfunction in Critical Illness

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