Severe Myopericarditis in Diabetic Ketoacidosis—All Troponin are Not Myocardial Infarction

Abstract

Uncontrolled diabetes and acute coronary syndrome share a complex dynamic that results in significant ambiguity when interpreting biomarker elevations in this setting. This is concerning because myocardial infarction has been shown to be the most common cause of death in the first 24 hours of admission for uncontrolled diabetes. Literature shows that elevation in cardiac biomarkers in patients with uncontrolled diabetes could be from viral myopericarditis, although a clear clinical significance is still lacking.1 It is, however, clear that elevation in cardiac biomarkers portends a poor long-term prognosis in patients with uncontrolled diabetes mellitus. We present a rare case of myopericarditis in a middle-aged patient with uncontrolled diabetes. The patient had elevated troponin I level reaching a peak of 7.3 ng/mL with associated ST elevations on electrocardiography. Coronary angiogram was subsequently done revealing clean coronaries. To our knowledge, this is the first description of myopericarditis in uncontrolled diabetes without a known cause.

Myocardial dysfunction associated with diabetic ketoacidosis in a 5-year-old girl

“…The patient had elevated troponin I level and ST elevations on electrocardiography with no angiographic evidence of occlusive coronary artery disease. 15…”

Diabetic Ketoacidosis-Induced Cardiomyopathy and Reversible Dialysis-Dependent Renal Failure With Successful Outcome: A Report of a Rare Case

“…There are several reported cases of TCM in the setting of diabetic ketoacidosis (DKA) in the literature. Most of which were linked to underlying sepsis, thyrotoxicosis, hypothermia, or simply the systemic inflammatory response [2][3][4][5][6]. To our knowledge, there have been few cases of non-TCM in the setting of DKA.…”