Severe Myopia as a Risk Factor for Progressive Visual Field Loss in Primary Open-Angle Glaucoma

Chihara, Etsuo; Liu, Xiao; Dong, Jing; Takashima, Yasuyuki; Akimoto, Masayuki; Hangai, Masanori; Kuriyama, Sei; Tanihara, Hidenobu; Hosoda, Motohiro; Tsukahara, Shigeo

doi:10.1159/000310760

Cited by 159 publications

(99 citation statements)

References 28 publications

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“…It disagrees with findings from the Los Angeles Latino Eye Study [45]. The correlation between hyperopia and lower intraocular pressure, or in other words the correlation between myopia and higher intraocular pressure, does not explain the association between myopia and glaucoma as described in the Beijing Eye Study and other investigations [30,[46][47][48], since the multivariate analysis included intraocular pressure as a potentially confounding factor. Our study therefore confirms previous population-based studies and hospital-based investigations on the association between glaucoma and high myopia [30,[46][47][48].…”

Section: P-valuecontrasting

confidence: 75%

Refractive error, ocular and general parameters and ophthalmic diseases. The Beijing Eye Study

You

Jonas

2009

Graefes Arch Clin Exp Ophthalmol

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In the adult Chinese population, hyperopic subjects compared with myopic subjects were older, lived predominately in the rural regions, had a lower level of education, smoked more, and were more obese. In addition, the hyperopic subjects had a lower intraocular pressure, a higher best-corrected visual acuity, a shallower anterior chamber depth and narrower anterior chamber angle, lower amount of nuclear cataract, smaller beta zone of parapapillary atrophy, a lower prevalence of open-angle glaucoma, and a higher prevalence of age-related macular degeneration.

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Section: P-valuecontrasting

confidence: 75%

Refractive error, ocular and general parameters and ophthalmic diseases. The Beijing Eye Study

You

Jonas

2009

Graefes Arch Clin Exp Ophthalmol

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“…A prospective study of untreated NTG (Drance et al 2001) and retrospective studies of untreated NTG (Araie et al 1994) or treated NTG (Ishida et al 1998(Ishida et al , 2000Sohn et al 2010) all failed to find a significant association of further progression and myopia. Regarding high myopia, two studies showed that it was a risk factor for the progression of VF in treated POAG patients (Chihara et al 1997;Perdicchi et al 2007). However, high myopia may differ from nonhighly myopic eyes not only in refractive error, but also in pathology (Curtin 1985b;Jonas & Dichtl 1997;Jonas et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Risk factors for progression of normal‐tension glaucoma under β‐blocker monotherapy

Araie

Shirato²,

Yamazaki

et al. 2012

Acta Ophthalmologica

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ABSTRACT.Purpose: To prospectively study prognostic factors for normal-tension glaucoma (NTG) under treatment with topical b-blocker. Methods: One hundred and forty-six eyes of 146 patients with NTG with a mean untreated intraocular pressure (IOP) of 14 mmHg, mild to moderate visual field damage and mean spherical equivalent refraction of )3.5 ()8.0 to +2.0) dioptre were randomized to topical nipradilol or timolol and followed for 3 years. The Humphrey full threshold 30-2 visual field test was performed every 6 months, and optic disc photographs were obtained every 12 months. Progression was defined as visual field progression, optic disc and ⁄ or peripapillary nerve fibre layer change, and factors relating to progression were evaluated using Cox proportional hazards models. Results: IOP decreased by 1.0 mmHg over the 3-year period, during which 35% showed progression according to the aforementioned criteria. Optic disc haemorrhage (hazard ratio [HR] 4.00, p < 0.001) and less extent of myopia (per dioptre, HR 1.15, p = 0.013) were significant risk factors. When progression was defined by visual field progression only, less extent of myopia was again a significant risk factor (HR 1.17, p = 0.038). Conclusion: Beside optic disc haemorrhage, less extent of myopia was a risk factor for progression in the current NTG population where most patients were mildly myopic and IOP during follow-up averaged 13.2 mmHg under topical b-blocker.

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“…In clinical practice it is relevant to evaluate the RNFL of myopic eyes because myopia is a well-known risk factor for occurrence and progression of primary open-angle glaucoma [24,25,26]. The outcome of this study shows that myopic eyes are not different from emmetropic eyes in terms of RNFL thickness, as assessed by many SLP parameters; in addition, in some cases RNFL thickness seems to be higher in myopic eyes (TSNIT average, Superior average, Ellipse average, Symmetry).…”

Section: Discussionmentioning

confidence: 99%

The Influence of Low to Moderate Myopia on Retinal Nerve Fiber Layer as Assessed by Scanning Laser Polarimetry with Variable Corneal Compensator

Vetrugno

Trabucco²,

Sisto³

et al. 2007

Ophthalmologica

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Purpose: To evaluate the influence of different degrees of myopia on retinal nerve fiber layer (RNFL) as measured by scanning laser polarimetry (SLP) with variable corneal compensator (VCC) in healthy eyes. Methods: One hundred and seventy-four healthy age-matched subjects with low to high myopic and emmetropic eyes underwent RNFL measurement by means of GDxVCC. The GDx parameters included in the analysis were: Temporal-superior-nasal-inferior thickness (TSNIT) average, Superior average, Inferior average, TSNIT standard deviation, Inter-eye symmetry, NFI, Symmetry, Superior ratio, Inferior ratio, Superior/nasal, Maximum modulation, Superior maximum, Inferior maximum, Ellipse modulation, Normalized superior area, Normalized inferior area, Ellipse standard deviation, Ellipse average. The mean value of each SLP parameter of myopic eyes was compared with the mean value of the same parameter of emmetropic eyes. Results: Mean myopia was 3.9 ± 1.5 dpt (range: –2 to –8.25 dpt). TNSIT average was higher in myopic group (p = 0.0111), together with Superior average (p = 0.0244), Symmetry (p < 0.0001) and Ellipse average (p = 0.0111). Two ratio parameters, Superior ratio and Inferior ratio, were higher in emmetropic eyes (p = 0.0179 in both cases). In both the myopic and the emmetropic group, all the SLP assessments of the RNFL fell within the normal range, according to the GDx database. Conclusions: Low to high myopia is not related to clinically relevant variations of SLP parameters, as assessed with GDx-VCC.

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Severe Myopia as a Risk Factor for Progressive Visual Field Loss in Primary Open-Angle Glaucoma

Cited by 159 publications

References 28 publications

Refractive error, ocular and general parameters and ophthalmic diseases. The Beijing Eye Study

Refractive error, ocular and general parameters and ophthalmic diseases. The Beijing Eye Study

Risk factors for progression of normal‐tension glaucoma under β‐blocker monotherapy

The Influence of Low to Moderate Myopia on Retinal Nerve Fiber Layer as Assessed by Scanning Laser Polarimetry with Variable Corneal Compensator

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