Severe nail psoriasis with a rapid response to acitretin

Castillo, Virginia López; Gallardo, Inmaculada Molina; Fajardo, Nuria Martí; Hernández, José María; Cuevas, Esperanza Jordá

doi:10.1111/j.1365-2230.2009.03282.x

Cited by 8 publications

(2 citation statements)

References 3 publications

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“…acitretin is a metabolite of etretinate that helps normalize cell differentiation in psoriasis and acts as an anti-inflammatory. 41 Tosti et al 42 treated 36 patients with acitretin 0.2 to 0.3 mg/kg/day for nail psoriasis. after 6 months of treatment, mean Napsi and modified Napsi scores were reduced by 41% and 50%, respectively.…”

Section: Acitretinmentioning

confidence: 99%

Nail Psoriasis: A Review of Treatment

Kerensky

Gottlieb

2010

Psoriasis Forum

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Nail psoriasis is a common and disabling manifestation of cutaneous plaque-type psoriasis. Treatment of nail psoriasis is often unsuccessful and frequently requires prolonged and tedious treatment regimens to achieve or maintain remission. The clinician may choose from a variety of treatment modalities, including topical, intralesional, radiation, and systemic modes of therapy. The objective of this review is to summarize the available treatment options and assess their effectiveness for the treatment of nail psoriasis.

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Section: Acitretinmentioning

confidence: 99%

Nail Psoriasis: A Review of Treatment

Kerensky

Gottlieb

2010

Psoriasis Forum

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“…Vitamin A for nail psoriasis treatment is available as tazarotene, a topical vitamin A derivative, and oral synthetic retinoids. Mechanism of action is decreased epidermal hyperproliferation, normalization of cellular differentiation, and inflammatory control [69,80].…”

Section: Introductionmentioning

confidence: 99%

Vitamins for the Management of Nail Disease: A Literature Review

Curtis,

Lipner

2023

Skin Appendage Disord

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Background: Vitamins have gained popularity among physicians and patients for purported benefits to hair, skin, and nail health. Safe and efficacious therapies for nail disorders, many of which are chronic conditions, are needed. Summary: We conducted a literature review of studies assessing the efficacy of oral, topical, and intralesional vitamin/vitamin derivatives for the treatment of nail disorders, including yellow nail syndrome, brittle nail syndrome, onychomycosis, habit-tic nail deformity, periungual/subungual verruca, and nail psoriasis. Forty-nine articles were reviewed. There is good evidence to support the use of topical tazarotene and vitamin D analogs for nail psoriasis treatment. We found overall limited evidence for treatment of other nail disorders with vitamin/vitamin derivatives, and further research is needed to support their use. Key Messages: Besides topical tazarotene and vitamin D analogs for nail psoriasis treatment, there is limited evidence for treatment of nail disorders with topical, oral, and intralesional vitamin/vitamin derivatives.

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Acitretin

2013

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Acitretin, a synthetic retinoid, is the pharmacologically active metabolite of etretinate. It is currently approved by the US Food and Drug Administration for the treatment of severe psoriasis in adults and has been established as a second-line therapy for the treatment of psoriasis resistant to the use of topical therapy. It is also an option for generalized pustular psoriasis, palmoplantar pustulosis, exfoliative erythrodermic psoriasis, and severe psoriasis in the setting of acitretin. It also has been shown to have chemo-preventative characteristics. Acitretin is limited by its teratogenicity and therefore considered inappropriate in most female patients of childbearing age. Common side effects include mucocutaneous dryness and elevated triglycerides.

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Severe nail psoriasis with a rapid response to acitretin

Cited by 8 publications

References 3 publications

Nail Psoriasis: A Review of Treatment

Nail Psoriasis: A Review of Treatment

Vitamins for the Management of Nail Disease: A Literature Review

Acitretin

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