Severe Ocular Irritation and Corneal Deposits Associated with Capecitabine Use

Waikhom, B; Ft, Fraunfelder; Wd, Henner

doi:10.1056/nejm200009073431015

Cited by 29 publications

(18 citation statements)

References 2 publications

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“…A previous report in humans documented a corneal deposit in 2 patients administered CAP. This deposit resolved with drug withdrawal and recurred when the drug was administered again 57 . The dogs in our study had a more severe toxicity, evidenced by development of superficial keratitis, but 1 dog ultimately developed a deposit similar to the previously reported human cases.…”

Section: Discussionsupporting

confidence: 78%

Use of Capecitabine to Prevent Acute Renal Allograft Rejection in Dog Erythrocyte Antigen‐Mismatched Mongrel Dogs

et al. 2007

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Section: Discussionsupporting

confidence: 78%

Use of Capecitabine to Prevent Acute Renal Allograft Rejection in Dog Erythrocyte Antigen‐Mismatched Mongrel Dogs

et al. 2007

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“…These results were similar to those induced by N-Ethyl-N-Nitrosourea (ENU) in mice treated with 600 mg/ kg group for 7 days [42] as well as to those induced by cisplatin treatment [43] . In addition, these results were consistent with the clinical results of some authors [15] who reported two cases having ocular irritation, decreased vision and corneal deposits associated with capecitabine use. Moreover, such corneal structural changes were consistent with the clinical findings in patients receiving other anticancer alkylating agents who complain of photophobia, foreign body sensation and tearing due to corneal epitheliopathy [44] .…”

Section: Discussionsupporting

confidence: 92%

“…Diarrhea, hand-foot syndrome and oromandibular dystonia are frequent complications for capecitabine treatment [12][13][14] . Moreover, ocular complications such as ocular irritation, decreased vision and corneal deposits have been associated with capecitabine therapy [15] .…”

Section: Introductionmentioning

confidence: 99%

The Potential Protective Role of Hesperidin Against Capecitabine-Induced Corneal Toxicity in Adult Male Albino Rat. Light and Electron Microscopic Study

Elwan

Kassab

2017

Egyptian Journal of Histology

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Background: Capecitabine is a chemotherapeutic agent widely used for the treatment of malignancies. Ocular disorders have been reported with capecitabine therapy. Hesperidin is a naturally occurring compound derived mainly from citrus fruits and has a wide range of pharmacological activities and a proposed role in combating many ocular diseases. Aim: To evaluate the potential protective role of hesperidin against the corneal toxicity caused by capecitabine in adult male albino rats. Material and Methods: Thirty-six adult male albino rats were divided into four equal groups; control group, hesperidintreated group (50 mg/kg), capecitabine-treated group (40 mg/kg), and combination-treated "capecitabine and hesperidintreated" group. Animals were orally administered once daily for one month. Specimens from the cornea were processed for light and electron microscopy. Immunohistochemical study was performed using antibodies against p53. Results: Specimens from capecitabine-treated animals showed significant decrease of epithelial thickness. The corneal epithelial cells showed nuclear alteration and vacuolated cytoplasm. The stromal collagen fibers were irregularlyarranged and widely separated with neovascularization and mononuclear cellular infiltration. Ultrastructurally, focal widening of the intercellular spaces, partial loss of desmosomal junctions and swollen mitochondria were observed. The immunohistochemical study showed a significant increase in p53 immunoreaction. In contrast, minimal changes were observed in rats treated concomitantly with both capecitabine and hesperidin, with a non significant increase in the immunoreactions. Conclusion: Capecitabine induced structural changes in cornea of adult albino rat that could be ameliorated by concomitant treatment with hesperidin.

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“…http://www.rocheusa.com/ products/xeloda/, 2005). 1,7 CPC has also been used as an immunosuppressive agent to counteract canine renal transplant rejection. 4 Ocular adverse effects were noted in this renal study and led to an examination by a veterinary ophthalmologist and veterinary ophthalmic pathologist.…”

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confidence: 99%

Histopathologic Evidence of Capecitabine Corneal Toxicity in Dogs

et al. 2007

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In an experimental model of transplant rejection, renal transplants were performed on 6 mixed-breed dogs. Capecitabine (CPC) was administered as an oral immunosuppressive agent. All recipients received systemic CPC, cyclosporine (CSA), prednisolone, and famotidine throughout the study. Two dogs developed superficial keratitis, which was characterized by multifocal geographic erosions, superficial corneal epithelial pigmentation, and corneal neovascularization. These clinical signs correlated with the dose of CPC given, whereas other drug doses remained unchanged. After euthanasia, routine histologic sections were stained with hematoxylin and eosin and with alcian blue periodic acid-Schiff for light microscopic evaluation. Ocular histopathologic abnormalities were limited to neovascularization and inflammatory infiltrate of the anterior corneal stroma and abnormal basal cell morphology, disorganization, thinning, and pigmentation of the corneal epithelium. The purpose of this communication is to describe the clinical and histopathologic evidence of CPC corneal toxicity in dogs.

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Severe Ocular Irritation and Corneal Deposits Associated with Capecitabine Use

Cited by 29 publications

References 2 publications

Use of Capecitabine to Prevent Acute Renal Allograft Rejection in Dog Erythrocyte Antigen‐Mismatched Mongrel Dogs

Use of Capecitabine to Prevent Acute Renal Allograft Rejection in Dog Erythrocyte Antigen‐Mismatched Mongrel Dogs

The Potential Protective Role of Hesperidin Against Capecitabine-Induced Corneal Toxicity in Adult Male Albino Rat. Light and Electron Microscopic Study

Histopathologic Evidence of Capecitabine Corneal Toxicity in Dogs

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