Severe ophthalmia neonatorum in Southwest China: a 5-year review of demographics, microbiological results, and risk factors

Tang, Xiao-Jiao; He, Jia-Tong; Liu, Qing; Chen, Xin-Ke; Chen, Lin

doi:10.1007/s10792-022-02218-4

Cited by 3 publications

(5 citation statements)

References 27 publications

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“…For example, The most common organism causing neonatal conjunctivitis in Nepal was coagulase negative S. aureus (30%), Klebsiella (20%) and Pseudomonas (10%) [4]. However, the most commonly detected organisms in Southwest China were S. aureus (29%) and S. epidermis (27%), E. coli (8%), and N. gonorrhea (8%) [5]. Thus, understanding the composition of the bacterial community in neonatal bacterial conjunctivitis is important in the development of healthcare.…”

Section: Backgroudmentioning

confidence: 99%

“…The detection rate of S. aureus was range from 27.6-67.9% of neonatal conjunctivitis in different regions or countries [9,12,13]. For example, a 5 year retrospective review in Southwest China also suggested that S. aureus (29%) is the most common pathogen of severe neonatal conjunctivitis [5]. Previous study reported that S. aureus are related to all kinds of eye infections, and are the main causative agents of these infections [14].…”

Section: Clinical Characteristic Of Neonatal Conjunctivitis Caused By...mentioning

confidence: 99%

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Pathogenic and clinical features of neonatal bacterial conjunctivitis in southern China: a retrospective study

Luo,

Gu,

Sun

et al. 2024

Preprint

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Background: Bacterial conjunctivitis is one of the most common ocular problems of neonates. The aim of this study was to retrospectively analyse the clinical and pathogenic characteristics of neonatal bacterial conjunctivitis in southern China from 2017 to 2021. Methods: Clinical and microbiological data of neonates with culture-proven bacterial conjunctivitis in our hospital were retrospectively collected from January 2017 to December 2021. Then, the distribution of the pathogens, the clinical characteristics and the antimicrobial susceptibility patterns were evaluated. Results: Bacteria was separated from 299 samples (30.9%) out of the 967 samples assessed, and 8 patients were infected by two bacteria. A total of 307 pathogens were identified, of which 211 (67.2%) were Gram-positive, and 96 (30.1%) were Gram-negative. S. aureus (53.7%) was the most frequent causative organism, followed by C. macginleyi (10.7%) and E. coli (10.1%). Only one case of N. gonorrhoeae was isolated. An increasing detection rate during the last five years (χ2=16.68, P<0.001) was observed, and a similar trend was found in Gram-positive bacteria (χ2=9.898, P=0.002). Gram-negative bacteria related neonatal conjunctivitis were common among neonates suffered turbid amniotic fluid. Fifty-two S. aureus isolates (34.2%) were methicillin-resistant S. aureus (MRSA) and 5 strains (15.6%) E.coli were extended spectrum b-lactamases (ESBLs) producing bacteria. All S. aureus and C. macginleyi strains are susceptible to vancomycin and linezolid, and E. coli are susceptible to imipenem, ertapenem and amikacin. Conclusion: Although most of neonatal bacterial conjunctivitis are self-limiting disease, investigating the pathogenic characteristics and antibiotics parttern may help to shorten the duration of conjunctival symptoms in neonates with acute bacterial conjunctivitis.

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Section: Backgroudmentioning

confidence: 99%

Section: Clinical Characteristic Of Neonatal Conjunctivitis Caused By...mentioning

confidence: 99%

Pathogenic and clinical features of neonatal bacterial conjunctivitis in southern China: a retrospective study

Luo,

Gu,

Sun

et al. 2024

Preprint

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“…P. aeruginosa and S. aureus are also implicated in the aetiology of ophthalmia neonatorum [152][153][154][155][156][157], as well as microbial keratitis in adults including in cases of contact lens wear [7,[158][159][160][161][162][163][164][165][166]. Fluoroquinolones have also been used for treatment of ophthalmia neonatorum [143] and microbial keratitis [166][167][168][169].…”

Section: Log Reductionmentioning

confidence: 99%

A novel ex vivo bovine corneal infection and clearance model for Neisseria gonorrhoeae, Staphylococcus aureus, and Pseudomonas aeruginosa

Ukachukwu

Alany

Snyder

2023

Preprint

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Ocular infections caused by bacterial pathogens may damage the cornea and rapidly progress to permanent blindness. Topical application of an ophthalmic formulation is often used to treat corneal infections. The animal models used in many preclinical studies frequently involve expensive in vivo experiments that compromises the corneal epithelium to mimic real life conditions such as during contact lens wear, but these do not consider other instances where infection occurs in intact corneas such as in ophthalmia neonatorum. To develop an ex vivo model of infection, bovine eyes from human food chain waste were processed and the corneas inoculated with Neisseria gonorrhoeae strain NCCP 11945, Staphylococcus aureus strain 6571, and Pseudomonas aeruginosa strain ATCC 15442 for 1 hour, 4 hours, and 6 hours, respectively. Inoculation included intact bovine corneas and those compromised with scalpel, needle, and blot methods. Recovery of N. gonorrhoeae, S. aureus, and P. aeruginosa colonies demonstrated that infection of bovine corneas was achieved with intact and compromised corneas using this model. In addition, corneas inoculated with the bacteria were treated with a suitable antibiotic, demonstrating clearance of the bacterial infections with at least 5 log10 reduction. This model is appropriate for both establishing infection and testing the ability of antimicrobial agents to clear bacterial eye infections. The bovine ex vivo model is reliable, cost-effective, suitable for different bacteria species, and reduces the need for further animal exploitation in laboratory research.

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“…A substantial proportion of infective neonatal conjunctivitis is culture negative, however. A recent retrospective review of neonatal conjunctivitis cases over a five year period in southwest China found that only 46% of eye swabs yielded a positive result 5. Failure to achieve a positive culture is often due to antibiotic treatment before microbiology sampling, inadequate sampling, or contamination of samples with normal skin flora 5.…”

Section: What Causes It?mentioning

confidence: 99%

“…A recent retrospective review of neonatal conjunctivitis cases over a five year period in southwest China found that only 46% of eye swabs yielded a positive result 5. Failure to achieve a positive culture is often due to antibiotic treatment before microbiology sampling, inadequate sampling, or contamination of samples with normal skin flora 5. Therefore, neonatal conjunctivitis remains a clinical diagnosis based on presenting features, with laboratory confirmation being a welcome adjunct.…”

Section: What Causes It?mentioning

confidence: 99%

Approach to conjunctivitis in newborns

Manasseh

Amarakoon

Photiou

et al. 2022

BMJ

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Severe ophthalmia neonatorum in Southwest China: a 5-year review of demographics, microbiological results, and risk factors

Cited by 3 publications

References 27 publications

Pathogenic and clinical features of neonatal bacterial conjunctivitis in southern China: a retrospective study

Pathogenic and clinical features of neonatal bacterial conjunctivitis in southern China: a retrospective study

A novel ex vivo bovine corneal infection and clearance model for Neisseria gonorrhoeae, Staphylococcus aureus, and Pseudomonas aeruginosa

Approach to conjunctivitis in newborns

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