Severe oral lichen planus: treatment with an aromatic retinoid (etretinate)

Hersle, K; Mobacken, H; Sloberg, K.; Thilander, H

doi:10.1111/j.1365-2133.1982.tb00904.x

Cited by 96 publications

(51 citation statements)

References 9 publications

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“…Indeed, topical steroids or retinoic acid are usually inefficient. Beneficial effects of dapsone and griseofulvin have been only occasionally reported [1,2], Systemic steroids or retinoids are reported by most authors to give satisfying results [3]; however, high doses are often necessary for several months lead ing to poorly tolerated side effects [4], For this reason, we have attempted to treat four patients with locally applied ciclosporin A (CsA) in an open trial.…”

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confidence: 99%

Effect of the Local Application of Ciclosporine A on Chronic Erosive Lichen planus of the Oral Cavity

et al. 1988

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mentioning

confidence: 99%

Effect of the Local Application of Ciclosporine A on Chronic Erosive Lichen planus of the Oral Cavity

et al. 1988

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“…Thus, systemic therapies, such as oral retinoids and cyclosporine, are scarce, of questionable efficacy, and with significant adverse events [14,15,16,17,18]. As for the local therapies available, there is not strong evidence for the effectiveness of any single treatment, including topical corticosteroids, which are currently the first-line accepted therapy for OELP [1].…”

Section: Discussionmentioning

confidence: 99%

Antimalarial Drugs for the Treatment of Oral Erosive Lichen Planus

Rivas-Tolosa

Requena

Llombart³

et al. 2015

Dermatology

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Background: Treatment of oral erosive lichen planus is considered a therapeutic challenge. Various systemic and topical agents aimed at controlling the symptoms, rather than curing the lesions, have been used with varying results. Objective: To evaluate the response to treatment with antimalarial drugs in patients with oral erosive lichen planus. Methods: Eight patients diagnosed with oral erosive lichen planus were treated with antimalarial agents. The first clinical evaluation was made after a month of treatment and then every 2-3 months. Baseline ophthalmologic examinations were performed, and laboratory values were monitored before and during treatment. Results: All studied patients who had previously been resistant to other treatments responded favorably. Pain relief and reduced erythema and erosions were observed after of a mean of 2.4 months. Conclusion: Antimalarials may be useful for the treatment of oral erosive lichen planus. They are easily administered and affordable, with few adverse effects.

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“…Dosis más elevadas de etretinato, 75 mg/día, durante dos meses, proporcionan una mejoría clínica de las lesiones (47), pero a largo plazo (un año), los pacientes están en la misma situación que antes de iniciar el tratamiento (48). Con estas dosis además se padecen muchos efectos adversos e incluso algunos pacientes, tienen que suspender el tratamiento (47).…”

Section: Retinoides Sistémicosunclassified

Tratamiento del liquen plano oral: una revisión

Vallejo

Martín

2008

Av Odontoestomatol

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García-Pola Vallejo MJ, García Martín JM. Tratamiento del liquen plano oral: una revisión RESUMENEl objetivo del presente estudio fue realizar una revisión sobre los actuales tratamientos del liquen plano oral (LPO). Antes de iniciar el tratamiento al paciente, debe de realizarse una biopsia para establecer el correcto diagnóstico. Dado que para el LPO no hay tratamiento curativo, el primer objetivo en los pacientes sintomá-ticos es el efecto paliativo. Entre las alternativas terapéuticas se incluyen: corticosteroides tópicos, sistémicos e intralesionales; retinoides tópicos o sistémicos; ciclosporina tópica, tacrolimus tópico, azatioprina, fototerapia y tratamiento quirúrgico.Palabras clave: Liquen plano, tratamiento, corticosteroides, retinoides, ciclosporina, tacrolimus, azatioprina, fototerapia. SUMMARYThe aim of the present study was to review about the current treatment of oral lichen planus (OLP). Before a patients is started on therapy a biopsy must be done to establish an accurate diagnosis. Because there is no curative therapy for OLP, the primary goal for symtomatic patients is palliative. Treatment modalities include the use of: topical, systemic and intralesional corticosteroids; topical and systemic retinoids, topical cyclosoporine; topical tacrolimus; azathioprine; phototherapy and surgical procedures. Key words:Oral lichen planus, treatment, corticosteroids, retinoids, cyclosporine, tacrolimus, azathioprine, phototherapy. Tratamiento del liquen plano oral: una revisión García-Pola Vallejo MJ*, García Martín JM** Fecha de recepción: INTRODUCCIÓNLa indicación del tratamiento del liquen plano oral (LPO) se plantea una vez que se haya confirmado el diagnóstico de la enfermedad mediante la aplicación de criterios clínicos y estudios histopatológicos; y si fueran necesarios también inmunológicos (1, 2).El enfoque terapéutico se realizará en función de los siguientes parámetros: la forma clínica; los síntomas; la localización y extensión del LPO; así como el fracaso de previos tratamientos (3).Básicamente los objetivos del tratamiento del LPO serán: la eliminación de las lesiones atróficas y erosivas, controlar los síntomas y disminuir el potencial maligno de la lesión (4).El primer paso a tener en cuenta es la eliminación de factores locales que pudieran exacerbar la le-

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Severe oral lichen planus: treatment with an aromatic retinoid (etretinate)

Cited by 96 publications

References 9 publications

Effect of the Local Application of Ciclosporine A on Chronic Erosive Lichen planus of the Oral Cavity

Effect of the Local Application of Ciclosporine A on Chronic Erosive Lichen planus of the Oral Cavity

Antimalarial Drugs for the Treatment of Oral Erosive Lichen Planus

Tratamiento del liquen plano oral: una revisión

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