Severe paracoccidioidomycosis, with a fatal outcome and incidence related to an environmental event

Stringuini, Fernanda Altoé; Naback, Priscila Oliveira; Araújo, Luciana Ferreira de; Lima, Ricardo Barbosa; Martins, Carlos José

doi:10.1016/j.abd.2021.12.006

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…Among these cases, we highlight that one individual was coinfected with schistosomiasis and the other with hepatitis C, diseases classically described as causes of portal hypertension 4,5 . Furthermore, hepatic involvement by PCM is also described in the medical literature as a consequence of perihepatic lymph node obstruction, inflammatory ductal fibrosis or even periampullary obstructive lesion, resulting in jaundice due to cholestatic syndrome 4,5,6,7,8,9,10 . The rare cases that indicate this clinical manifestation highlight the importance of the differential diagnosis of PCM with proliferative diseases and periampullary tumors.…”

Section: Discussionmentioning

confidence: 99%

Disseminated juvenile paracoccidoidomycosis evolving with portal hypertension: a case report

de Souza Bayão,

Barille,

Rodrigues Diniz

et al. 2024

RBPS

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Introduction: Juvenile paracoccidioidomycosis (PCM), a disease caused by fungi of the genus Paracoccidioides, requires high clinical suspicion, as a range of differential diagnoses are possible. Case report: This report describes a patient diagnosed with juvenile PCM who, due to low adherence to treatment, developed a more extensive fungal invasion within eight years, causing portal hypertension due to portal vein thrombosis. This is a rare and serious manifestation. Conclusion: Only six similar reports were identified in the medical literature, through a search in the databases of the Pubmed and Scielo platforms.

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Section: Discussionmentioning

confidence: 99%

Disseminated juvenile paracoccidoidomycosis evolving with portal hypertension: a case report

de Souza Bayão,

Barille,

Rodrigues Diniz

et al. 2024

RBPS

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“…Genetic material of P. brasiliensis was detected in soil samples [ 12 ], reinforcing the hypothesis that there is a correlation between the construction and the increase in the number of acute cases. Furthermore, other health services also reported severe and atypical cases of the acute form of the disease in the metropolitan area of the state [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Trends in the Epidemiological and Clinical Profile of Paracoccidioidomycosis in the Endemic Area of Rio de Janeiro, Brazil

Falcão,

Freitas,

Coutinho

et al. 2023

JoF

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Paracoccidioidomycosis (PCM) is a neglected endemic mycosis in Latin America. Most cases occur in Brazil. It is classified as PCM infection and PCM disease and is subdivided into chronic (adult type) or acute (juvenile type) disease, with the latter being less frequent and more severe. In 2016, we reported an increase in the numbers of patients diagnosed with acute PCM after a highway’s construction. We conducted a study at INI-Fiocruz, a reference center for infectious diseases, including endemic mycoses, in Rio de Janeiro, Brazil, aiming to deepen the analysis of this new clinical and epidemiological profile of PCM. The authors developed a retrospective study including 170 patients diagnosed with PCM between 2010 and 2019. There was an increase in the number of atypical and severe forms, starting in 2014. In subsequent years, we detected a higher incidence of adverse outcomes with patients requiring more hospitalizations and an increased mortality rate. We estimate that PCM has become more severe throughout the Rio de Janeiro state, affecting a greater number of young individuals and leading to a greater number of and longer hospitalizations. Surveillance measures and close monitoring of future notification data in the state, with emphasis on children, adolescents, and young adults are necessary for a better understanding of the perpetuation of this public health challenge.

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“…This disease is endemic in Latin America, with Brazil having the highest number of registered cases. The fungus has different species that vary according to the region in which they are found 2 .…”

Section: Introductionmentioning

confidence: 99%

Mortality trends due to Paracoccidioidomycosis in Brazil – 1996 to 2020

Maslinkiewicz,

Gomes Valente,

Russo Mini

et al. 2023

Rev Cienc Saude

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Objective: To analyze the trend in mortality from paracoccidioidomycosis (PCM) and characterize the sociodemographic profile in Brazil and its geographic regions in a 25-year time series. Methods: This is an ecological time series study. The study participants were the Brazilian population divided into age groups whose underlying cause of death was PCM. To calculate the annual percentage change (VPA) of the coefficients in the trend analysis, the Prais-Winsten regression was used. National mortality coefficients were calculated according to geographic regions, sex and age group and proportional to the other variables. Results: According to this study, there were 2,101 deaths from PCM in Brazil. The trend over the 25 years showed stable behavior in the North and Northeast regions. In the South, Southeast, and Midwest, there was a downward trend. The average mortality in Brazil was 84.04/100,000 inhab., VPA -3.29 (95% CI -2.43; -4.14). According to the analysis of sociodemographic aspects, there was a predominance of ignored schooling (764 deaths; 36%), white race/skin color (1,109; 53%), mixed marital status: married (942; 45%) and single (640; 30%), and place of death predominantly in the hospital environment (1,852; 88%). Conclusion: In Brazil and in the Southeast, South, andMidwest geographic regions, mortality from PCM showed a decreasing temporal trend. In the Northeast and North regions, the trend was stationary. The sociodemographic profile of the dying patients indicated males, adults, with low education, white, and married.

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Severe paracoccidioidomycosis, with a fatal outcome and incidence related to an environmental event

Cited by 5 publications

References 9 publications

Disseminated juvenile paracoccidoidomycosis evolving with portal hypertension: a case report

Disseminated juvenile paracoccidoidomycosis evolving with portal hypertension: a case report

Trends in the Epidemiological and Clinical Profile of Paracoccidioidomycosis in the Endemic Area of Rio de Janeiro, Brazil

Mortality trends due to Paracoccidioidomycosis in Brazil – 1996 to 2020

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