2014
DOI: 10.1097/inf.0000000000000456
|View full text |Cite|
|
Sign up to set email alerts
|

Severe Parechovirus Infection in Norwegian Infants

Abstract: A new HPeV-3-strain caused sepsis-like disease and meningoencephalitis in 15 Norwegian infants. All but 1 recovered within a few weeks.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

2
13
0

Year Published

2015
2015
2025
2025

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 27 publications
(15 citation statements)
references
References 24 publications
2
13
0
Order By: Relevance
“…However, we were unable to identify any acute clinical or diagnostic features from these children's original hospitalisation that was associated with these outcomes, although we did note a trend towards longer total length of stay in hospital amongst infants with significant developmental concern. 2 A further concern is that many infants in our cohort with significant concern in neurodevelopment had been previously described as having 'recovered fully'. MRI) were not performed on most infants.…”
Section: Discussionmentioning
confidence: 93%
See 2 more Smart Citations
“…However, we were unable to identify any acute clinical or diagnostic features from these children's original hospitalisation that was associated with these outcomes, although we did note a trend towards longer total length of stay in hospital amongst infants with significant developmental concern. 2 A further concern is that many infants in our cohort with significant concern in neurodevelopment had been previously described as having 'recovered fully'. MRI) were not performed on most infants.…”
Section: Discussionmentioning
confidence: 93%
“…10,11,19 Amongst our cohort, MRI was performed infrequently (7/42), although HPeV was identified from the CSF in the majority (91%; 31/34 tested). 11 Furthermore, the characteristic MRI in this condition is of symmetrical white matter diffusion restriction 2,4,10,11,20,21 . 11 Cases of HPeV infection have been described where full recovery has been described despite acute MRI abnormalities; however, these cases have not been assessed using standardised outcome measures.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…HPeV may cause death among young patients, with one relatively large study reporting mortality from HPeV infection among young infants as high as 6%30. HPeV3 may be associated with more severe clinical symptoms particular in very young infants compared to other HPeV types, is the predominant type associated with CNS infection and/or sepsis-like presentations in early infancy and is the most common type identified in cerebrospinal fluid (CSF) samples12303132333435363738. The range and severity of clinical manifestations and prognosis of HPeV3 infection is not well defined.…”
mentioning
confidence: 99%
“…It should be noted that our MAbs did not cross-react with the HPeV3 genotype, which has been shown to differ from HPeV1, -2, -4, -5, and -6 in many aspects (reviewed in reference 51). Clinically, HPeV3 differs from the other HPeVs since it infects young children and is associated with more severe disease (52,53). These differences in pathogenesis and cytopathogenicity between different HPeV types could be related to differences in receptor usage (as has been shown for HIV-1 [54]) and differences in the timing and quality of the developing antibody response.…”
Section: Discussionmentioning
confidence: 99%