Severe preeclampsia-eclampsia in young primigravid women: Subsequent pregnancy outcome and remote prognosis

Sibai, Bahaeddine M; El-Nazer, Adel; Gonzalez-Ruiz, Antonio

doi:10.1016/0002-9378(86)90336-4

Cited by 367 publications

(200 citation statements)

References 12 publications

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“…He concluded that preeclampsia did not cause later cardiovascular disease but that preeclampsia in later pregnancies was caused by preexisting (subclinical) cardiovascular disease. Sibai et al 33 followed women with severe preeclampsia rather than eclampsia with similar findings. Women with severe preeclampsia in only their first pregnancy did not have an increased risk of later life hypertension, whereas women with preeclampsia in later pregnancies had increased risk.…”

Section: Relation Of Preeclampsia To Cardiovascular Diseasementioning

confidence: 69%

Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy

et al. 2003

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Abstract-A Working Group on Research in Hypertension in Pregnancy was recently convened by the National Heart, Lung, and Blood Institute to determine the state of knowledge in this area and suggest appropriate directions for research. Hypertensive disorders in pregnancy, especially preeclampsia, are a leading cause of maternal death worldwide and even in developed countries increase perinatal mortality rates 5-fold. Much has been learned about preeclampsia, but gaps in the knowledge necessary to direct therapeutic strategies remain. Oxidative stress is a biologically plausible contributor to the disorder that may be amenable to intervention. Hypertension that antedates pregnancy (chronic hypertension) bears many similarities to hypertension in nonpregnant women, but the special setting of pregnancy demands information to guide evidence-based therapy. The recommendations of the Working Group are to attempt a clinical trial of antioxidant therapy to prevent preeclampsia that is be complemented by mechanistic research to increase understanding of the genetics and pathogenesis of the disorder. For chronic hypertension, clinical trials are recommended to direct choice of drugs, evaluate degree of control, and assess implications to the mother and fetus.Recommendations to increase participation in this research are also presented.

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Section: Relation Of Preeclampsia To Cardiovascular Diseasementioning

confidence: 69%

Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy

et al. 2003

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“…Patients with recurrent preeclampsia and those in whom preeclampsia started during the early stages of pregnancy presented higher risk of future hypertension. 9 Primiparae with preeclampsia who were evaluated 17 years after the pregnancy presented a positive association with insulin resistance and elevated blood pressure levels. 11 Mild hyperinsulinemia, which may be a cause or consequence of preeclampsia, possibly contributes towards increased risk of cardiovascular disease (CVD) in the future, with higher likelihood of developing diseases such as diabetes mellitus (DM), high systemic arterial pressure (SAP) and ischemic coronary disease.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for cardiovascular disease ten years after preeclampsia

et al. 2010

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CONTEXT AND OBJECTIVE: Preeclampsia is a gestational disease that occurs mainly among nulliparous women after the 20 th week of gestation, and frequently close to delivery. The effects of preeclampsia on women's blood pressure over the long term are still controversial. Patients with recurrent preeclampsia or preeclampsia in the early stages of pregnancy appear to present higher risk of hypertension. The aim of this study was to determine the risk factors for cardiovascular disease among women with preeclampsia 10 years earlier. DESIGN AND SETTING:Cross-sectional study at Hospital de Clínicas de Porto Alegre (HCPA). METHODS:Forty women with preeclampsia and 14 normotensive pregnant women followed up 10 or more years earlier at HCPA underwent clinical and laboratory examinations. Spearman's correlation coefficient was used to correlate body mass index (BMI) and systolic and diastolic pressures. The risk of developing hypertension was measured using the chi-square test. P < 0.05 was considered significant. RESULTS:The patients with preeclampsia 10 or more years earlier had significantly higher diastolic blood pressure (P = 0.047), BMI (P = 0.019) and abdominal circumference (P = 0.026). They presented positive correlations between BMI and diastolic blood pressure (0.341; P = 0.031) and between BMI and systolic blood pressure (0.407; P = 0.009). CONCLUSION:The patients with preeclampsia 10 or more years earlier had significantly higher diastolic blood pressure, BMI and abdominal circumference than did the control group. This emphasizes the importance of long-term follow-up assessment for cardiovascular risk factors among patients with preeclampsia.RESUMO CONTEXTO E OBJETIVO: Pré-eclâmpsia é uma doença gestacional que ocorre principalmente em mulheres nulíparas, após a vigésima semana de gestação e frequentemente próximo do parto. Os efeitos da pré-eclâmpsia sobre a pressão sanguínea das mulheres a longo prazo ainda são controversos.Pacientes com pré-eclâmpsia recorrente ou pré-eclâmpsia na fase inicial da gestação parecem apresentar maior risco para hipertensão. O objetivo foi determinar os fatores de risco para doença cardiovascular em mulheres com pré-eclâmpsia há 10 anos. TIPO DE ESTUDO E LOCAL: Estudo transversal, realizado no Hospital de Clínicas de Porto Alegre (HCPA).MÉTODO: Quarenta mulheres com pré-eclâmpsia e 14 mulheres grávidas com pressão arterial normal acompanhadas há 10 anos ou mais no HCPA foram submetidas a exames clínicos e laboratoriais. Para se encontrar a correlação entre índice de massa corporal (IMC) e as pressões sistólica e diastólica, foi calculado o coeficiente de correlação de Spearman. O risco de desenvolvimento de hipertensão foi calculado através do teste de qui-quadrado. P < 0,05 foi considerado significante. RESULTADOS:Pacientes com pré-eclâmpsia há 10 anos ou mais tiveram pressão arterial diastólica (PAD) (P = 0,047), IMC (P = 0,019) e circunferência abdominal (P = 0,026) mais elevadas e apresentaram correlações positivas entre IMC e PAD (0,341, P = 0,031) e sistólica (0,4...

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“…5,6 Although controversy exists between the reports in Caucasian populations, 7,8 the C242T polymorphism was associated with progression of CAD. 9 Since the aetiology of CAD seems to be comparable with that of preeclampsia and the higher risk of pre-eclamptic women to develop vascular-related diseases in later life, 10,11 we studied the prevalence of the CC-genotype, which is associated with highest superoxide production, in women with pre-eclampsia and/or haemolysis, elevated liver enzymes, low platelets (HELLP) syndrome and compared it with controls.…”

Section: Introductionmentioning

confidence: 99%

The C242T-polymorphism of the NADPH/NADH oxidase gene p22phox subunit is not associated with pre-eclampsia

et al. 2002

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Pre-eclampsia is a pregnancy-related multisystem disorder characterised by elevation of blood pressure and proteinuria, in which oxidative stress may play an important role. Blood pressure is partly controlled by O − 2 production by NADPH/NADH oxidase and recently it was shown that a C242T substitution in the p22phox gene was associated with coronary artery disease, in which elevated blood pressure and oxidative stress are also important pathophysiologic features. Therefore we studied the prevalence of the C242T polymorphism in the NADPH/NADH oxidase gene in women with preeclampsia and/or haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome as compared with women with a normotensive pregnancy. DNA from control women (n = 78), women with pre-eclampsia (n = 40), HELLP syndrome (n = 9) or women with HELLP compli-

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Severe preeclampsia-eclampsia in young primigravid women: Subsequent pregnancy outcome and remote prognosis

Cited by 367 publications

References 12 publications

Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy

Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy

Risk factors for cardiovascular disease ten years after preeclampsia

The C242T-polymorphism of the NADPH/NADH oxidase gene p22phox subunit is not associated with pre-eclampsia

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